NTDB

Overview

Name	mecA	Type	Regulator
Locus tag	ST4067_RS01010	Genome accession	NZ_CP065496
Coordinates	173110..173859 (+)	Length	249 a.a.
NCBI ID	WP_011225365.1	Uniprot ID	Q5M699
Organism	Streptococcus thermophilus strain 4067
Function	degradation of ComX (predicted from homology) Competence regulation

Genomic Context

Location: 168110..178859

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ST4067_RS00980 (ST4067_00985)	-	168685..168855 (+)	171	WP_011680664.1	hypothetical protein	-
ST4067_RS00985 (ST4067_00990)	-	168942..169049 (+)	108	WP_263604572.1	LPXTG cell wall anchor domain-containing protein	-
ST4067_RS00990 (ST4067_00995)	-	169136..169876 (-)	741	WP_263604573.1	amino acid ABC transporter ATP-binding protein	-
ST4067_RS00995 (ST4067_01000)	-	169876..171426 (-)	1551	WP_022096528.1	ABC transporter substrate-binding protein/permease	-
ST4067_RS01000 (ST4067_01005)	-	171629..172483 (+)	855	WP_041828107.1	undecaprenyl-diphosphate phosphatase	-
ST4067_RS01005 (ST4067_01010)	-	172629..172844 (-)	216	WP_011226805.1	DUF3021 family protein	-
ST4067_RS01010 (ST4067_01015)	mecA	173110..173859 (+)	750	WP_011225365.1	adaptor protein MecA	Regulator
ST4067_RS01015 (ST4067_01020)	-	173863..175020 (+)	1158	WP_002947632.1	glycosyltransferase family 4 protein	-
ST4067_RS01020 (ST4067_01025)	sufC	175181..175951 (+)	771	WP_002947634.1	Fe-S cluster assembly ATPase SufC	-
ST4067_RS01025 (ST4067_01030)	sufD	175988..177250 (+)	1263	WP_002947640.1	Fe-S cluster assembly protein SufD	-
ST4067_RS01030 (ST4067_01035)	-	177304..178536 (+)	1233	WP_011225367.1	cysteine desulfurase	-

Sequence

Protein

Download Length: 249 a.a. Molecular weight: 29157.70 Da Isoelectric Point: 4.0659

                                >NTDB_id=449215 ST4067_RS01010 WP_011225365.1 173110..173859(+) (mecA) [Streptococcus thermophilus strain 4067]

MEMKQINETTLKIMITMEDLEEHGMELKDFLIPQEKTEEFFYTVMDELDLPDNFKNSGMLSFRVTPRKDRVDVFVTKSDL

KEALDFNDLSDMEDYSGLSPEEFLKALEDNFMDKGDIEAHHKLEEHDKTLKEVDETMTEPAKEVAEETIREDYTHYVLAF

SDFDQVVTFAQGLKNVSVEGSEFYKLGDVYYMTILLYLADEPDYYANNMYARFLEYANVADRTRPYLQEHATILMEEDAL

PVLQATKWS

Nucleotide

Download Length: 750 bp

                                >NTDB_id=449215 ST4067_RS01010 WP_011225365.1 173110..173859(+) (mecA) [Streptococcus thermophilus strain 4067]

ATGGAAATGAAACAAATAAACGAGACAACTCTAAAAATCATGATTACCATGGAAGATCTTGAAGAACATGGTATGGAGCT

GAAAGATTTCTTGATTCCCCAGGAAAAAACAGAGGAATTTTTCTATACTGTCATGGATGAGTTGGACTTGCCTGATAACT

TTAAAAATAGTGGGATGTTGAGCTTCCGTGTCACGCCACGAAAGGATCGTGTGGATGTTTTTGTGACTAAATCAGATCTT

AAGGAAGCCCTTGATTTCAATGATTTGTCAGATATGGAAGACTATTCAGGACTTTCTCCAGAAGAATTCCTCAAAGCTCT

TGAAGATAACTTTATGGATAAGGGAGATATTGAAGCCCACCATAAGCTCGAAGAGCATGATAAGACCTTGAAAGAGGTTG

ATGAGACTATGACAGAGCCGGCTAAGGAAGTGGCTGAGGAAACTATTCGTGAAGATTATACTCACTATGTCTTGGCTTTC

TCTGACTTTGATCAAGTAGTGACCTTTGCGCAAGGTTTGAAGAATGTGTCAGTGGAAGGTTCTGAATTTTATAAACTTGG

TGATGTCTACTATATGACTATCCTTCTTTACTTGGCTGATGAGCCTGATTATTACGCGAACAATATGTATGCGCGTTTTC

TTGAATATGCGAATGTGGCAGACCGAACACGTCCCTATCTACAAGAGCATGCAACAATCTTGATGGAAGAGGACGCCTTA

CCGGTATTACAAGCAACGAAATGGAGCTAG

Domains

Predicted by InterProScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-242)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	Q5M699

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
mecA	Streptococcus thermophilus LMG 18311	100	100	1
mecA	Streptococcus thermophilus LMD-9	99.197	100	0.992
mecA	Streptococcus mutans UA159	57.377	97.992	0.562
mecA	Streptococcus pneumoniae Rx1	46.185	100	0.462
mecA	Streptococcus pneumoniae D39	46.185	100	0.462
mecA	Streptococcus pneumoniae R6	46.185	100	0.462
mecA	Streptococcus pneumoniae TIGR4	46.185	100	0.462

Detailed information NTG0449215