Detailed information    

insolico Bioinformatically predicted

Overview

Name   comR   Type   Regulator
Locus tag   GE021_RS00305 Genome accession   NZ_CP053792
Coordinates   53131..54042 (+) Length   303 a.a.
NCBI ID   WP_125074313.1    Uniprot ID   A0A3P5Y668
Organism   Streptococcus canis strain HL_77_1     
Function   activate transcription of comX (predicted from homology)   
Competence regulation

Genomic Context

Location: 48131..59042
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  GE021_RS00290 (GE021_000290) purE 49634..50125 (+) 492 WP_125074315.1 5-(carboxyamino)imidazole ribonucleotide mutase -
  GE021_RS00295 (GE021_000295) purK 50112..51182 (+) 1071 WP_125074314.1 5-(carboxyamino)imidazole ribonucleotide synthase -
  GE021_RS00300 (GE021_000300) purB 51700..52992 (+) 1293 WP_003046005.1 adenylosuccinate lyase -
  GE021_RS00305 (GE021_000305) comR 53131..54042 (+) 912 WP_125074313.1 helix-turn-helix domain-containing protein Regulator
  GE021_RS11105 comS 54129..54230 (+) 102 WP_217267493.1 quorum-sensing system DWW-type pheromone Regulator
  GE021_RS00310 (GE021_000310) ruvB 54263..55261 (+) 999 WP_125074312.1 Holliday junction branch migration DNA helicase RuvB -
  GE021_RS00315 (GE021_000315) - 55403..55846 (+) 444 WP_125074311.1 low molecular weight protein-tyrosine-phosphatase -
  GE021_RS00320 (GE021_000320) - 55863..56264 (+) 402 WP_125074310.1 MORN repeat-containing protein -
  GE021_RS00325 (GE021_000325) - 56261..58036 (+) 1776 WP_164406344.1 acyltransferase family protein -

Sequence

Protein


Download         Length: 303 a.a.        Molecular weight: 36083.65 Da        Isoelectric Point: 4.9565

>NTDB_id=447244 GE021_RS00305 WP_125074313.1 53131..54042(+) (comR) [Streptococcus canis strain HL_77_1]
MLEHFGEKVKGLRQEKKISREDLCGDESELSVRQLARIELSQSIPSLAKVIFIAKALDVSVGYLTDGANLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDQLPEEEQVAIDIIQAKFEVYQTGNINFGSSILKEFLPQLKRKVIYNLNE
LLLIDLYLVTLVVSHFADDLFDRELYNKITERILKQNHHLMLEDLFLLNNILLSCADTSIRLEMFGRLKETLQLSHFIMS
TIQDFQRMPIYCMYEWKLSIFYLKDVERARNYYEQSILFTQMTSDYYLVERLHKEWHKDIQQI

Nucleotide


Download         Length: 912 bp        

>NTDB_id=447244 GE021_RS00305 WP_125074313.1 53131..54042(+) (comR) [Streptococcus canis strain HL_77_1]
ATGTTAGAGCATTTTGGTGAAAAAGTGAAAGGGCTAAGACAAGAGAAAAAGATTAGCAGAGAAGACTTATGTGGGGATGA
GTCTGAATTATCTGTTCGTCAACTAGCGAGGATTGAGTTGAGCCAGTCTATACCAAGTTTAGCCAAGGTTATTTTTATTG
CAAAAGCCTTAGATGTTAGCGTAGGTTATTTGACTGATGGGGCCAACCTTGAGTTACCCAAACGTTACAAAGAGTTAAAA
TATTTAATTCTGCGGACACCAACTTATATGGATGATGGCAAATTACAAGTTCGAGAAGAACAGTTTGATGAGATATTTGA
GGATTACTATGACCAGCTGCCTGAGGAGGAGCAGGTGGCTATTGATATTATTCAAGCAAAATTTGAAGTTTACCAAACTG
GGAATATTAATTTTGGATCTAGTATTTTAAAAGAATTTTTACCACAACTTAAAAGGAAAGTTATTTATAATTTAAATGAG
TTGCTTTTGATAGATTTGTATTTAGTTACTTTGGTGGTTTCCCATTTTGCAGATGATTTATTTGACAGAGAGCTTTATAA
TAAGATTACAGAAAGAATTTTAAAACAAAACCATCATTTAATGTTGGAAGATTTATTTCTGCTGAATAATATTTTATTGT
CTTGTGCAGATACCTCTATTCGTTTAGAAATGTTTGGGAGACTAAAAGAGACGTTACAACTCAGTCATTTCATTATGTCA
ACTATTCAAGATTTTCAAAGAATGCCAATTTATTGTATGTATGAGTGGAAGTTATCTATCTTTTATTTAAAAGATGTTGA
ACGTGCTCGAAATTATTATGAACAATCTATTTTATTTACTCAAATGACTAGTGATTATTACCTGGTTGAGAGACTTCACA
AAGAATGGCATAAAGATATTCAACAGATATAG

Domains

Predicted by InterproScan.

Helix-turn-helix (HTH_3)

(12-64)

ComR tetratricopeptide (ComR_TPR)

(73-296)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A3P5Y668

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comR Streptococcus pyogenes MGAS315

84.818

100

0.848
  comR Streptococcus pyogenes MGAS8232

55.814

99.34

0.554
  comR Streptococcus mutans UA159

48.344

99.67

0.482
  comR Streptococcus infantarius subsp. infantarius ATCC BAA-102

44.746

97.36

0.436