Detailed information NTG0447302

Bioinformatically predicted

Overview

• Name: codY
• Type: Regulator
• Locus tag: ST4052_RS07430
• Genome accession: NZ_CP065476
• Coordinates: 1427638..1428423 (-)
• Length: 261 a.a.
• NCBI ID: WP_002951720.1
• Uniprot ID: Q5M305
• Organism: Streptococcus thermophilus strain 4052
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1422638..1433423

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ST4052_RS07395 (ST4052_07465)	gatC	1422704..1423006 (-)	303	WP_002884769.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
ST4052_RS07400 (ST4052_07470)	-	1423146..1423400 (-)	255	WP_011226449.1	glycosyl transferase	-
ST4052_RS07405 (ST4052_07475)	-	1423413..1423622 (-)	210	WP_011226450.1	glycosyltransferase	-
ST4052_RS07410 (ST4052_07480)	-	1423938..1425379 (-)	1442	Protein_1405	6-phospho-beta-glucosidase	-
ST4052_RS07415 (ST4052_07485)	msrA	1425532..1426041 (-)	510	WP_002946589.1	peptide-methionine (S)-S-oxide reductase MsrA	-
ST4052_RS07420 (ST4052_07490)	-	1426053..1426901 (-)	849	WP_041828318.1	MetQ/NlpA family ABC transporter substrate-binding protein	-
ST4052_RS07425 (ST4052_07495)	-	1427024..1427575 (-)	552	WP_002946999.1	isochorismatase family cysteine hydrolase	-
ST4052_RS07430 (ST4052_07500)	codY	1427638..1428423 (-)	786	WP_002951720.1	GTP-sensing pleiotropic transcriptional regulator CodY	Regulator
ST4052_RS07435 (ST4052_07505)	-	1428683..1429897 (-)	1215	WP_011226456.1	pyridoxal phosphate-dependent aminotransferase	-
ST4052_RS07440 (ST4052_07510)	-	1430252..1430704 (+)	453	WP_347100865.1	universal stress protein	-
ST4052_RS07445 (ST4052_07515)	-	1430884..1431455 (+)	572	Protein_1412	IS30 family transposase	-
ST4052_RS07450 (ST4052_07520)	-	1431527..1431700 (-)	174	WP_011681546.1	hypothetical protein	-
ST4052_RS07455 (ST4052_07525)	-	1431761..1432135 (-)	375	WP_041828320.1	membrane protein	-
ST4052_RS07460 (ST4052_07530)	pflA	1432347..1433147 (-)	801	WP_002946980.1	pyruvate formate-lyase-activating protein	-

Sequence

Protein

• Length: 261 a.a.
• Molecular weight: 28919.13 Da
• Isoelectric Point: 4.5802

>NTDB_id=447302 ST4052_RS07430 WP_002951720.1 1427638..1428423(-) (codY) [Streptococcus thermophilus strain 4052]
MANLLDKTRKITSILQRSVDSLEGDLPYNNMAAQLADIIDCNAAIVNGGGALLGFAMKYKTNNDRVEKFFKAKQLPEEYI
RGISRVYDTQENIGIDSDLTIFPVELKDDFPDGLTTIAPIYGGGMRLGSFIIWRNDHDFVDDDLILVEIASTVVGLQLLH
LQTENLEETIRKQTAINMAINTLSYSEIKAVSAILNELDGLEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLG
MKGTYLKVLNEGIYDKLKEYE

Nucleotide

• Length: 786 bp

>NTDB_id=447302 ST4052_RS07430 WP_002951720.1 1427638..1428423(-) (codY) [Streptococcus thermophilus strain 4052]
ATGGCAAATTTGCTTGATAAAACACGTAAAATTACTTCTATCTTGCAACGCTCAGTAGATAGTTTGGAAGGAGATCTTCC
ATACAACAACATGGCTGCTCAGTTGGCAGATATTATTGATTGTAATGCTGCTATTGTAAATGGTGGAGGTGCTCTCCTTG
GTTTTGCTATGAAATACAAAACCAACAATGACCGTGTGGAAAAGTTTTTTAAAGCTAAACAACTTCCAGAGGAATACATA
CGTGGTATCAGCCGTGTTTATGATACTCAAGAAAATATCGGTATTGACAGTGACTTGACCATCTTCCCAGTAGAATTAAA
AGATGATTTCCCTGACGGTTTGACTACAATTGCACCAATCTATGGTGGTGGTATGCGTCTTGGTTCTTTCATTATTTGGC
GTAACGACCATGATTTTGTGGACGACGACCTTATCTTGGTTGAGATTGCATCTACAGTAGTTGGTTTGCAATTGTTGCAT
CTTCAAACAGAAAACTTGGAAGAAACGATTCGTAAACAAACAGCTATTAATATGGCTATTAATACCTTATCTTACTCAGA
AATCAAGGCAGTTTCAGCTATCTTGAATGAGTTGGACGGTTTAGAAGGTCGTTTGACAGCCTCTGTTATCGCGGACCGTA
TCGGAATTACTCGTTCTGTTATTGTTAATGCTCTTCGTAAATTAGAATCAGCTGGTATTATTGAAAGTCGTTCGCTTGGT
ATGAAAGGTACTTACCTTAAAGTCCTTAACGAAGGTATCTACGACAAATTGAAAGAATACGAATAA

Domains

Predicted by InterProScan.

• CodY GAF-like domain (CodY) (3-182)

• CodY helix-turn-helix domain (HTH_CodY) (201-261)

3D structure

• AlphaFold DB: Q5M305

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
codY	Lactococcus lactis subsp. lactis strain DGCC12653	64.591	98.467	0.636
codY	Bacillus subtilis subsp. subtilis str. 168	53.036	94.636	0.502