Detailed information    

insolico Bioinformatically predicted

Overview

Name   pknB   Type   Regulator
Locus tag   GE023_RS08155 Genome accession   NZ_CP053789
Coordinates   1637391..1639286 (-) Length   631 a.a.
NCBI ID   WP_099982918.1    Uniprot ID   A0A2D4DM60
Organism   Streptococcus canis strain HL_98_2     
Function   modulate the activity of ComDE; modulate the activity of VicKR (predicted from homology)   
Competence regulation

Genomic Context

Location: 1632391..1644286
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  GE023_RS08130 (GE023_008125) - 1633141..1633500 (-) 360 WP_003044703.1 S1 RNA-binding domain-containing protein -
  GE023_RS08135 (GE023_008130) - 1633500..1634900 (-) 1401 WP_125073665.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  GE023_RS08140 (GE023_008135) - 1634937..1635578 (-) 642 WP_003044709.1 response regulator transcription factor -
  GE023_RS08145 (GE023_008140) - 1635571..1636575 (-) 1005 WP_159305987.1 sensor histidine kinase -
  GE023_RS08150 (GE023_008145) liaF 1636572..1637264 (-) 693 WP_093998979.1 cell wall-active antibiotics response protein LiaF -
  GE023_RS08155 (GE023_008150) pknB 1637391..1639286 (-) 1896 WP_099982918.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  GE023_RS08160 (GE023_008155) - 1639283..1640023 (-) 741 WP_003044720.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  GE023_RS08165 (GE023_008160) rsmB 1640061..1641383 (-) 1323 WP_099982919.1 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB -
  GE023_RS08170 (GE023_008165) fmt 1641373..1642308 (-) 936 WP_093998976.1 methionyl-tRNA formyltransferase -

Sequence

Protein


Download         Length: 631 a.a.        Molecular weight: 68841.17 Da        Isoelectric Point: 6.9928

>NTDB_id=447175 GE023_RS08155 WP_099982918.1 1637391..1639286(-) (pknB) [Streptococcus canis strain HL_98_2]
MIQIGKLFAGRYRILKSIGRGGMADVYLANDLILDNEDVAIKVLRTNYQTDQVAVARFQREARAMAELNHPNIVAIRDIG
EEDGQQFLVMEYVDGADLKKYIQDHAPLSNNEVVRIMEEVLSAMTLAHQKGIVHRDLKPQNILLTKNGVVKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATIQSDIYAMGIMLFEMLTGHIPYDGDSAVTIALQHFQKPLPSIIDENHNVP
QALENVVIRATAKKLSDRYGSTFEMSRDLMTALSYNRSRERKVIFDDVESTKPLPKVTPTPMTTPKVAPTPVTSTTESRL
EQTNQMDTLQKPQKKKRNGRFLGTLLKILFSLFIVGVALFTYLVLTKPTSVKVPDVTGVSLKVAKQELQDLGLKVGKVRQ
IESDTVAEGNVVRTDPQAGTAKRKGSSVTVYLSIGNKGFEMENYKGVDYQDAMNSLMETYGIPKSKIKIERIVTNEYPEN
TVISQSPSAGDKFNPNGKSKITLSVAVSDTVIMPMVTEYSYADAVNTLTALGIDASRIKAYAPSSSSATGFIQVNSPSSK
AIVSGQMPYYGTTLSLSEKGEISLYLYPEETHSSSSSSSSESSSSSSSTSDGTGTSSNTELNPSESTGQTP

Nucleotide


Download         Length: 1896 bp        

>NTDB_id=447175 GE023_RS08155 WP_099982918.1 1637391..1639286(-) (pknB) [Streptococcus canis strain HL_98_2]
ATGATTCAGATTGGCAAGTTATTTGCTGGTCGTTATCGTATTCTAAAATCTATTGGCCGCGGTGGTATGGCGGATGTTTA
TTTGGCAAATGATTTGATCTTGGATAATGAAGACGTTGCAATCAAAGTTTTGCGTACCAATTATCAAACAGATCAGGTGG
CAGTTGCGCGTTTCCAACGGGAAGCGCGGGCCATGGCTGAATTGAACCATCCGAATATTGTTGCCATCCGGGATATAGGT
GAAGAAGACGGACAGCAATTTTTAGTAATGGAATATGTTGATGGTGCTGACCTAAAGAAGTACATTCAAGATCATGCACC
GCTATCCAATAACGAAGTGGTTAGAATCATGGAAGAGGTTCTTTCTGCCATGACTCTGGCTCACCAAAAAGGAATTGTGC
ATAGGGATTTAAAACCTCAAAACATTCTCTTAACTAAAAATGGTGTGGTTAAGGTGACTGACTTTGGGATTGCTGTTGCC
TTTGCAGAAACGAGTTTGACTCAGACCAACTCGATGTTAGGTAGTGTGCATTATTTGTCTCCGGAGCAGGCTCGTGGTTC
AAAGGCAACTATCCAAAGTGACATTTATGCAATGGGGATTATGCTCTTTGAAATGCTGACAGGGCATATTCCTTATGACG
GTGACAGTGCTGTTACGATTGCCTTGCAACATTTTCAAAAGCCTCTTCCGTCTATTATTGACGAAAATCACAATGTGCCG
CAAGCTTTAGAGAATGTTGTTATCCGAGCAACAGCCAAGAAATTGAGTGATCGTTATGGGTCTACTTTTGAGATGAGCCG
TGACTTGATGACGGCGCTTAGCTACAACCGTAGCCGTGAACGTAAAGTCATTTTTGATGATGTGGAAAGCACTAAGCCGC
TTCCCAAAGTAACTCCAACGCCAATGACAACACCAAAAGTTGCGCCGACTCCAGTTACTTCAACAACTGAAAGTAGATTA
GAGCAAACCAATCAAATGGACACGCTCCAAAAGCCACAAAAAAAGAAAAGAAATGGTCGTTTTTTAGGAACCTTATTGAA
GATTCTTTTTTCTCTCTTTATTGTGGGGGTGGCTCTTTTTACTTACTTGGTATTAACTAAGCCAACTTCTGTGAAAGTTC
CTGATGTAACAGGTGTTAGCTTGAAAGTAGCTAAGCAAGAACTACAAGATCTTGGTCTAAAAGTAGGAAAGGTGCGGCAA
ATTGAAAGCGATACTGTCGCTGAAGGAAATGTTGTCCGAACAGACCCACAAGCAGGAACAGCTAAGCGTAAAGGATCAAG
TGTAACTGTTTATTTGTCAATCGGAAATAAAGGTTTTGAAATGGAAAACTACAAAGGGGTTGATTATCAAGATGCTATGA
ACAGCTTGATGGAAACCTATGGCATTCCAAAATCTAAGATTAAAATTGAACGTATTGTGACCAATGAGTATCCTGAAAAT
ACTGTTATTAGCCAGTCACCAAGTGCAGGAGATAAGTTTAATCCCAATGGTAAATCTAAAATTACCCTTAGCGTAGCCGT
TAGTGACACAGTCATTATGCCAATGGTTACAGAATATAGTTATGCTGATGCGGTTAATACTTTGACAGCACTGGGTATTG
ATGCCTCTAGGATAAAAGCTTATGCGCCAAGTTCAAGTTCAGCAACTGGTTTTATTCAGGTTAATTCCCCTAGTTCAAAA
GCTATTGTTAGTGGACAGATGCCTTATTATGGTACGACATTGAGTCTTTCTGAAAAAGGAGAGATAAGCCTTTATCTTTA
TCCAGAAGAAACACACTCTTCAAGTAGTTCCTCAAGTTCAGAATCAAGTTCAAGTAGTTCCTCAACAAGTGATGGCACTG
GGACAAGTAGCAATACCGAATTAAACCCGTCAGAATCGACTGGACAAACACCTTGA

Domains

Predicted by InterproScan.

Protein kinase domain (Pkinase)

(12-233)

PASTA domain (PASTA)

(371-433)

PASTA domain (PASTA)

(440-505)

PASTA domain (PASTA)

(511-587)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2D4DM60

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pknB Streptococcus mutans UA159

65.529

92.868

0.609
  stkP/pknB Streptococcus salivarius strain HSISS4

62.203

93.502

0.582
  stkP Streptococcus pneumoniae TIGR4

58.221

81.933

0.477
  stkP Streptococcus pneumoniae D39

57.803

82.25

0.475
  stkP Streptococcus pneumoniae R6

57.803

82.25

0.475
  stkP Streptococcus pneumoniae Rx1

57.834

81.933

0.474