Detailed information    

insolico Bioinformatically predicted

Overview

Name   vicR   Type   Regulator
Locus tag   MGAS1882_RS02225 Genome accession   NC_017053
Coordinates   428238..428948 (+) Length   236 a.a.
NCBI ID   WP_002985645.1    Uniprot ID   -
Organism   Streptococcus pyogenes MGAS1882     
Function   repress comCDE expression; repress comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 423238..433948
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MGAS1882_RS02205 (MGAS1882_0457) - 424090..424239 (+) 150 WP_002990686.1 hypothetical protein -
  MGAS1882_RS02210 (MGAS1882_0458) - 424634..425782 (+) 1149 WP_014407392.1 acetyl-CoA C-acyltransferase -
  MGAS1882_RS02215 (MGAS1882_0459) - 425739..426986 (+) 1248 WP_014407393.1 AMP-binding protein -
  MGAS1882_RS02220 (MGAS1882_0460) - 427042..428076 (+) 1035 WP_014407394.1 DUF3114 domain-containing protein -
  MGAS1882_RS02225 (MGAS1882_0461) vicR 428238..428948 (+) 711 WP_002985645.1 response regulator YycF Regulator
  MGAS1882_RS02230 (MGAS1882_0462) vicK 428941..430293 (+) 1353 WP_014407395.1 cell wall metabolism sensor histidine kinase VicK Regulator
  MGAS1882_RS02235 (MGAS1882_0463) vicX 430297..431106 (+) 810 WP_002985641.1 MBL fold metallo-hydrolase Regulator
  MGAS1882_RS02240 (MGAS1882_0464) rnc 431549..432241 (+) 693 WP_002990670.1 ribonuclease III -

Sequence

Protein


Download         Length: 236 a.a.        Molecular weight: 27083.99 Da        Isoelectric Point: 4.9038

>NTDB_id=44524 MGAS1882_RS02225 WP_002985645.1 428238..428948(+) (vicR) [Streptococcus pyogenes MGAS1882]
MKKILIVDDEKPISDIIKFNLTKEGYDIVTAFDGREAVTIFEEEKPDLIILDLMLPELDGLEVAKEIRKTSHVPIIMLSA
KDSEFDKVIGLEIGADDYVTKPFSNRELLARVKAHLRRTETIETAVAEENASSGTQELTIGNLQILPDAFVAKKHGQEVE
LTHREFELLHHLANHMGQVMTREHLLEIVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMKSYD

Nucleotide


Download         Length: 711 bp        

>NTDB_id=44524 MGAS1882_RS02225 WP_002985645.1 428238..428948(+) (vicR) [Streptococcus pyogenes MGAS1882]
ATGAAAAAAATACTTATTGTGGATGATGAAAAACCGATTTCTGACATTATTAAGTTTAATTTGACAAAAGAAGGTTATGA
CATTGTTACAGCTTTTGATGGACGCGAAGCGGTAACAATTTTTGAAGAAGAAAAGCCAGATTTAATTATTCTTGATTTGA
TGCTCCCTGAGTTGGACGGTCTTGAAGTAGCCAAGGAAATTCGTAAAACCAGTCATGTCCCGATTATTATGTTGTCGGCT
AAAGATAGTGAGTTTGACAAGGTTATTGGACTTGAAATTGGGGCTGATGATTACGTGACCAAGCCCTTTTCTAATCGGGA
ATTGCTGGCACGTGTCAAGGCTCATCTGCGTCGTACCGAAACTATTGAAACGGCTGTTGCAGAAGAAAATGCTTCTTCAG
GTACACAGGAACTAACCATTGGTAATTTACAGATTTTACCAGATGCGTTTGTTGCTAAAAAACATGGTCAAGAGGTAGAG
TTGACCCATCGTGAATTTGAACTATTGCATCATCTAGCTAACCATATGGGGCAGGTGATGACACGAGAACACTTATTGGA
AATTGTTTGGGGATATGATTATTTTGGCGATGTGCGCACGGTTGATGTGACTGTTCGTCGTCTCCGTGAAAAAATTGAAG
ACACACCAAGTCGTCCTGAGTATATTTTAACAAGACGTGGTGTTGGGTACTACATGAAATCTTATGACTAG

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-113)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(156-231)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vicR Streptococcus mutans UA159

90.254

100

0.903
  micA Streptococcus pneumoniae Cp1015

79.06

99.153

0.784
  covR Streptococcus salivarius strain HSISS4

44.828

98.305

0.441
  covR Lactococcus lactis subsp. lactis strain DGCC12653

44.397

98.305

0.436
  scnR Streptococcus mutans UA159

36.91

98.729

0.364

Multiple sequence alignment