Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   MGAS15252_RS01280 Genome accession   NC_017040
Coordinates   245120..245881 (+) Length   253 a.a.
NCBI ID   WP_014407297.1    Uniprot ID   -
Organism   Streptococcus pyogenes MGAS15252     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 240120..250881
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MGAS15252_RS01265 (MGAS15252_0262) - 240378..241946 (-) 1569 WP_014407294.1 ABC transporter substrate-binding protein/permease -
  MGAS15252_RS01270 (MGAS15252_0263) - 242144..244069 (+) 1926 WP_014407295.1 DUF2207 domain-containing protein -
  MGAS15252_RS01275 (MGAS15252_0264) - 244135..244974 (+) 840 WP_014407296.1 undecaprenyl-diphosphate phosphatase -
  MGAS15252_RS01280 (MGAS15252_0265) mecA 245120..245881 (+) 762 WP_014407297.1 adaptor protein MecA Regulator
  MGAS15252_RS01285 (MGAS15252_0266) - 245888..247057 (+) 1170 WP_014407298.1 glycosyltransferase family 4 protein -
  MGAS15252_RS01290 (MGAS15252_0267) sufC 247179..247949 (+) 771 WP_002986023.1 Fe-S cluster assembly ATPase SufC -
  MGAS15252_RS01295 (MGAS15252_0268) sufD 248044..249306 (+) 1263 WP_014407299.1 Fe-S cluster assembly protein SufD -
  MGAS15252_RS01300 (MGAS15252_0269) - 249337..250563 (+) 1227 WP_011054183.1 cysteine desulfurase -

Sequence

Protein


Download         Length: 253 a.a.        Molecular weight: 29078.75 Da        Isoelectric Point: 4.1622

>NTDB_id=44384 MGAS15252_RS01280 WP_014407297.1 245120..245881(+) (mecA) [Streptococcus pyogenes MGAS15252]
MEMKQISETTLKITISMDDLEERGMELKDFLIPQEKTEEFFYSVMDELDLPDNFKDSGMLSFRVTPRKDRLDVFVTKSEI
NKDINLEDLAEFGDMSQMTPEDFFKSLEQSMREKGDVKAHEKLEKIEEIMEDVVEATLANQSEAADPSTNHESEPLDYVH
YVLDFSTITEAVAFAKTIDFSIEASELYKGNNCYHMTILLDVQQQPSYFANVMYARLIEHANPGSKTRAYLQEHGLQLML
DGAVEQLQKIELG

Nucleotide


Download         Length: 762 bp        

>NTDB_id=44384 MGAS15252_RS01280 WP_014407297.1 245120..245881(+) (mecA) [Streptococcus pyogenes MGAS15252]
ATGGAAATGAAACAAATTAGCGAGACAACGCTAAAAATAACAATTAGTATGGACGATTTAGAAGAAAGAGGAATGGAGTT
GAAAGATTTCTTGATTCCTCAAGAAAAAACAGAAGAGTTTTTCTATTCTGTGATGGACGAACTCGATCTTCCAGATAATT
TTAAAGATAGTGGTATGCTTAGTTTTCGAGTGACTCCACGCAAGGACCGTCTAGATGTTTTTGTTACCAAATCTGAGATA
AATAAAGATATTAATCTTGAAGATTTAGCAGAGTTTGGTGATATGTCCCAAATGACTCCGGAAGATTTTTTCAAGAGCTT
GGAGCAATCCATGCGTGAAAAGGGAGATGTCAAAGCTCATGAAAAATTGGAAAAAATTGAAGAGATAATGGAAGATGTTG
TTGAAGCTACTCTAGCTAATCAGTCTGAGGCGGCTGATCCATCAACTAATCATGAGTCAGAACCTTTAGACTATGTCCAT
TATGTATTGGATTTTTCAACGATTACAGAGGCAGTGGCTTTTGCTAAAACGATTGATTTTTCGATAGAAGCTTCAGAGTT
ATATAAGGGGAACAACTGCTACCATATGACTATTTTATTAGATGTTCAGCAACAACCATCTTATTTTGCGAATGTCATGT
ATGCGAGATTGATTGAGCATGCAAACCCTGGATCAAAAACAAGAGCTTATTTACAAGAGCATGGCTTACAATTGATGCTT
GATGGTGCTGTTGAGCAATTACAAAAGATTGAGTTGGGATAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-247)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus mutans UA159

62.8

98.814

0.621
  mecA Streptococcus thermophilus LMD-9

56.225

98.419

0.553
  mecA Streptococcus thermophilus LMG 18311

55.422

98.419

0.545
  mecA Streptococcus pneumoniae Rx1

48.627

100

0.49
  mecA Streptococcus pneumoniae D39

48.627

100

0.49
  mecA Streptococcus pneumoniae R6

48.627

100

0.49
  mecA Streptococcus pneumoniae TIGR4

48.627

100

0.49

Multiple sequence alignment