Detailed information NTG0442748

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: HHM66_RS00360
• Genome accession: NZ_CP053074
• Coordinates: 57621..58532 (+)
• Length: 303 a.a.
• NCBI ID: WP_003060893.1
• Uniprot ID: A0AAE9U6L1
• Organism: Streptococcus dysgalactiae subsp. equisimilis strain TPCH-A88
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 52621..63532

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HHM66_RS00335 (HHM66_00335)	purE	53121..53609 (+)	489	WP_015057187.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
HHM66_RS00340 (HHM66_00340)	purK	53596..54669 (+)	1074	WP_170078118.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
HHM66_RS00345 (HHM66_00345)	-	54679..55935 (+)	1257	WP_015057188.1	DUF4041 domain-containing protein	-
HHM66_RS00350 (HHM66_00350)	-	55928..56137 (+)	210	WP_014611912.1	hypothetical protein	-
HHM66_RS00355 (HHM66_00355)	purB	56186..57478 (+)	1293	WP_003056595.1	adenylosuccinate lyase	-
HHM66_RS00360 (HHM66_00360)	comR	57621..58532 (+)	912	WP_003060893.1	XRE family transcriptional regulator	Regulator
HHM66_RS10845	comS	58619..58717 (+)	99	WP_198763767.1	quorum-sensing system DWW-type pheromone	Regulator
HHM66_RS00365 (HHM66_00365)	ruvB	58751..59749 (+)	999	WP_015057190.1	Holliday junction branch migration DNA helicase RuvB	-
HHM66_RS00370 (HHM66_00370)	-	59884..60315 (+)	432	WP_003059365.1	low molecular weight protein-tyrosine-phosphatase	-
HHM66_RS00375 (HHM66_00375)	-	60344..60745 (+)	402	WP_003049089.1	MORN repeat-containing protein	-
HHM66_RS00380 (HHM66_00380)	-	60742..62517 (+)	1776	WP_003059359.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35995.62 Da
• Isoelectric Point: 4.7392

>NTDB_id=442748 HHM66_RS00360 WP_003060893.1 57621..58532(+) (comR) [Streptococcus dysgalactiae subsp. equisimilis strain TPCH-A88]
MLEHFGEKVRGLRLEKGISREELCGDEAELSVRQLARIELGQSIPSLAKVIFIAKALEVSVGYLTDGANLELPKRYKELK
YLILRTPTYMDDRKLQVRESQFDEIFENYYDQLPEEEKIAIDIIQAKFEVYQTGDINFGFNILKEFLPQLKKKTVYNLNE
LLLIDLYLIILVVSNFTNDLFDEEFYKEITERILEQHQYLLLEDLFLLNNILLSCADTSIRLKMFERLKDTLQLSHFIMS
TIQDFQRMPMYCMYEWKLSIFYLKDIKRAETYFSQSLTFTQMTNDSYLAQKLQKEWDKDIHPS

Nucleotide

• Length: 912 bp

>NTDB_id=442748 HHM66_RS00360 WP_003060893.1 57621..58532(+) (comR) [Streptococcus dysgalactiae subsp. equisimilis strain TPCH-A88]
ATGTTAGAGCATTTTGGTGAAAAAGTGAGAGGATTAAGACTTGAGAAAGGGATTAGTCGAGAGGAATTGTGTGGAGATGA
GGCAGAATTGTCTGTTCGCCAGTTGGCGAGGATAGAGCTAGGTCAATCTATACCAAGTTTAGCGAAGGTTATTTTTATTG
CGAAAGCCTTAGAGGTCAGCGTCGGTTATTTGACGGATGGCGCTAACCTAGAACTCCCTAAACGATATAAAGAGTTAAAA
TATCTTATTTTAAGGACTCCGACTTATATGGACGATCGCAAATTACAGGTCCGGGAGTCTCAGTTTGATGAGATATTTGA
AAACTATTATGATCAATTGCCTGAGGAGGAAAAAATAGCGATTGATATTATCCAGGCAAAATTTGAAGTTTATCAGACAG
GTGATATTAATTTTGGTTTTAATATTTTAAAAGAATTTCTACCACAACTAAAAAAGAAAACGGTTTATAACTTAAATGAA
TTATTATTAATTGATTTATATTTAATTATTTTAGTTGTTTCTAACTTTACAAATGACCTATTTGATGAGGAATTTTATAA
AGAAATAACGGAGCGAATCTTAGAACAGCATCAATACCTGTTATTAGAAGATTTATTTCTATTAAATAATATTCTTTTAT
CTTGCGCAGATACTTCTATTCGTTTAAAAATGTTTGAACGACTAAAGGATACGTTACAACTCAGCCATTTTATTATGTCA
ACCATTCAAGATTTTCAGCGAATGCCCATGTATTGCATGTATGAATGGAAATTGTCTATCTTTTATTTAAAAGATATTAA
ACGAGCAGAAACTTATTTTAGTCAATCTCTCACGTTTACTCAAATGACTAATGATAGTTATTTGGCACAAAAGCTTCAAA
AAGAATGGGATAAGGATATTCATCCCTCTTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS315	83.389	99.34	0.828
comR	Streptococcus pyogenes MGAS8232	55.629	99.67	0.554
comR	Streptococcus mutans UA159	46.154	98.68	0.455
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	46.575	96.37	0.449
comR	Streptococcus suis P1/7	37.288	97.36	0.363
comR	Streptococcus suis 05ZYH33	37.288	97.36	0.363