NTDB

Overview

Name	vicR	Type	Regulator
Locus tag	HKK59_RS04025	Genome accession	NZ_CP053027
Coordinates	757517..758227 (+)	Length	236 a.a.
NCBI ID	WP_000722052.1	Uniprot ID	X5K3L1
Organism	Streptococcus agalactiae strain 01173
Function	repress comCDE expression; repress comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 752517..763227

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HKK59_RS04000 (HKK59_04015)	-	753619..754185 (+)	567	WP_000592391.1	PepSY domain-containing protein	-
HKK59_RS04005 (HKK59_04020)	-	754234..754884 (-)	651	WP_000100031.1	amino acid ABC transporter permease	-
HKK59_RS04010 (HKK59_04025)	-	754896..755591 (-)	696	WP_000173642.1	amino acid ABC transporter permease	-
HKK59_RS04015 (HKK59_04030)	-	755604..756410 (-)	807	WP_001932636.1	transporter substrate-binding domain-containing protein	-
HKK59_RS04020 (HKK59_04035)	-	756422..757177 (-)	756	WP_000053145.1	amino acid ABC transporter ATP-binding protein	-
HKK59_RS04025 (HKK59_04040)	vicR	757517..758227 (+)	711	WP_000722052.1	response regulator YycF	Regulator
HKK59_RS04030 (HKK59_04045)	vicK	758220..759569 (+)	1350	WP_001065469.1	cell wall metabolism sensor histidine kinase VicK	Regulator
HKK59_RS04035 (HKK59_04050)	vicX	759573..760382 (+)	810	WP_001289497.1	MBL fold metallo-hydrolase	Regulator
HKK59_RS04040 (HKK59_04055)	-	760385..760753 (+)	369	WP_000719384.1	YbaN family protein	-
HKK59_RS04045 (HKK59_04060)	rnc	760929..761615 (+)	687	WP_000661526.1	ribonuclease III	-

Sequence

Protein

Download Length: 236 a.a. Molecular weight: 27063.90 Da Isoelectric Point: 4.8246

                                >NTDB_id=442188 HKK59_RS04025 WP_000722052.1 757517..758227(+) (vicR) [Streptococcus agalactiae strain 01173]

MKKILIVDDEKPISDIIKFNLTKEGYETATAFDGREALVQYAEFQPDLIILDLMLPELDGLEVAKEVRKTSHIPIIMLSA

KDSEFDKVIGLEIGADDYVTKPFSNRELLARVKAHLRRTENIETAVAEESAQNASSDITIGELQILPDAFIAKKRGEEIE

LTHREFELLHHLATHIGQVMTREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPGRPEYILTRRGVGYYMKSYE

Nucleotide

Download Length: 711 bp

                                >NTDB_id=442188 HKK59_RS04025 WP_000722052.1 757517..758227(+) (vicR) [Streptococcus agalactiae strain 01173]

ATGAAAAAAATACTTATCGTTGATGATGAAAAACCAATTTCAGATATTATCAAATTTAATTTAACCAAAGAAGGATATGA

GACGGCGACAGCTTTCGATGGCCGTGAAGCTTTAGTACAATATGCAGAATTTCAACCAGATTTAATCATTTTGGATTTAA

TGCTTCCTGAACTAGATGGTTTAGAAGTGGCTAAGGAAGTTCGTAAAACCAGCCATATTCCTATTATTATGCTTTCTGCA

AAAGACAGTGAGTTTGACAAAGTCATTGGTTTAGAAATCGGTGCAGATGATTATGTTACTAAACCTTTTTCAAATCGTGA

ACTTTTGGCACGGGTCAAAGCACATTTACGACGTACTGAAAATATTGAAACAGCTGTAGCAGAAGAAAGTGCTCAAAATG

CTTCTTCAGATATTACTATTGGTGAGTTGCAAATTTTACCAGATGCCTTTATTGCTAAGAAACGTGGCGAAGAAATTGAA

TTAACGCACCGAGAATTTGAATTACTTCACCATTTAGCGACACATATCGGACAAGTCATGACACGCGAACATTTATTGGA

AACAGTTTGGGGATATGATTATTTTGGAGATGTCCGTACAGTTGATGTGACGGTGAGACGTTTACGTGAAAAGATTGAAG

ATACTCCTGGTCGTCCAGAATATATTTTGACTCGACGTGGTGTAGGTTATTACATGAAGTCTTATGAATAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(156-231)

Response regulator receiver domain (Response_reg)

(4-113)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	X5K3L1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
vicR	Streptococcus mutans UA159	88.983	100	0.89
micA	Streptococcus pneumoniae Cp1015	77.778	99.153	0.771
covR	Lactococcus lactis subsp. lactis strain DGCC12653	46.983	98.305	0.462
covR	Streptococcus salivarius strain HSISS4	44.635	98.729	0.441
scnR	Streptococcus mutans UA159	38.559	100	0.386

Detailed information NTG0442188