Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   HHM65_RS05545 Genome accession   NZ_CP051624
Coordinates   1083362..1084036 (-) Length   224 a.a.
NCBI ID   WP_003060678.1    Uniprot ID   A0AAE9R380
Organism   Streptococcus dysgalactiae subsp. equisimilis strain TPCH-A74     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1078362..1089036
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HHM65_RS05520 (HHM65_05525) - 1078547..1079824 (-) 1278 WP_015057596.1 pyrimidine-nucleoside phosphorylase -
  HHM65_RS05525 (HHM65_05530) - 1079811..1080410 (-) 600 WP_015057597.1 class I SAM-dependent methyltransferase -
  HHM65_RS05530 (HHM65_05535) coaA 1080679..1081599 (+) 921 WP_012766986.1 type I pantothenate kinase -
  HHM65_RS05535 (HHM65_05540) rpsT 1081653..1081901 (+) 249 WP_009881183.1 30S ribosomal protein S20 -
  HHM65_RS05540 (HHM65_05545) ciaH 1082059..1083369 (-) 1311 WP_065957651.1 HAMP domain-containing sensor histidine kinase Regulator
  HHM65_RS05545 (HHM65_05550) ciaR 1083362..1084036 (-) 675 WP_003060678.1 response regulator transcription factor Regulator
  HHM65_RS05550 (HHM65_05555) - 1084240..1086777 (-) 2538 WP_014612305.1 M1 family metallopeptidase -
  HHM65_RS05555 (HHM65_05560) phoU 1086978..1087631 (-) 654 WP_003057760.1 phosphate signaling complex protein PhoU -
  HHM65_RS05560 (HHM65_05565) pstB 1087709..1088467 (-) 759 WP_003057749.1 phosphate ABC transporter ATP-binding protein PstB -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25601.58 Da        Isoelectric Point: 4.4684

>NTDB_id=439902 HHM65_RS05545 WP_003060678.1 1083362..1084036(-) (ciaR) [Streptococcus dysgalactiae subsp. equisimilis strain TPCH-A74]
MIKLLLVEDDLSLSNSIFDFLDDFADVTQVFDGDEGLYEAESGIYDLILLDLMLPEKNGFQVLKELREKDIKIPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRTGKFTDKNLAFGNVVVDLGQKEVQVDGRPIELLGKEFDLLVY
LLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKIRKKLKGTDFVDKLQTLRSVGYILKSHE

Nucleotide


Download         Length: 675 bp        

>NTDB_id=439902 HHM65_RS05545 WP_003060678.1 1083362..1084036(-) (ciaR) [Streptococcus dysgalactiae subsp. equisimilis strain TPCH-A74]
ATGATCAAACTATTATTAGTAGAAGATGACTTAAGTTTATCCAATTCCATTTTCGATTTTTTGGATGATTTTGCTGATGT
CACACAAGTTTTTGATGGCGATGAAGGCTTATATGAAGCCGAAAGTGGCATTTACGATTTGATTTTACTTGACCTTATGT
TGCCAGAAAAAAATGGCTTCCAAGTCTTGAAAGAATTGCGAGAAAAAGATATTAAAATTCCTGTGCTGATTATGACAGCC
AAAGAAAGCCTAGATGATAAGGGACATGGCTTTGAATTAGGAGCAGATGATTACCTCACTAAGCCTTTTTACCTGGAGGA
ACTCAAGATGCGAATTCAAGCCCTGTTAAAACGTACGGGGAAATTCACGGATAAAAATCTAGCCTTTGGGAATGTCGTAG
TGGATTTAGGGCAAAAAGAAGTTCAAGTGGATGGCCGGCCGATAGAACTATTAGGTAAAGAGTTTGATTTGTTGGTCTAC
CTTTTACAAAATCAGAATGTTATTTTACCTAAAACACAAATTTTTGATCGCTTATGGGGTTTTGATAGCGATACGACCAT
TTCAGTAGTTGAAGTTTACGTTTCTAAAATTAGAAAAAAACTGAAAGGTACAGATTTTGTGGACAAACTGCAGACATTGA
GAAGCGTGGGGTATATTCTAAAAAGCCATGAATAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)

Response regulator receiver domain (Response_reg)

(5-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

84.615

98.661

0.835
  ciaR Streptococcus pneumoniae D39

84.615

98.661

0.835
  ciaR Streptococcus pneumoniae R6

84.615

98.661

0.835
  ciaR Streptococcus pneumoniae TIGR4

84.615

98.661

0.835
  ciaR Streptococcus mutans UA159

84.163

98.661

0.83
  covR Lactococcus lactis subsp. lactis strain DGCC12653

38.326

100

0.388
  vicR Streptococcus mutans UA159

35.443

100

0.375