Detailed information NTG0439865

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: HHM65_RS00355
• Genome accession: NZ_CP051624
• Coordinates: 56646..57557 (+)
• Length: 303 a.a.
• NCBI ID: WP_003060893.1
• Uniprot ID: A0AAE9U6L1
• Organism: Streptococcus dysgalactiae subsp. equisimilis strain TPCH-A74
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 51646..62557

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HHM65_RS00330 (HHM65_00330)	purE	52146..52634 (+)	489	WP_015057187.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
HHM65_RS00335 (HHM65_00335)	purK	52621..53694 (+)	1074	WP_170078118.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
HHM65_RS00340 (HHM65_00340)	-	53704..54960 (+)	1257	WP_015057188.1	DUF4041 domain-containing protein	-
HHM65_RS00345 (HHM65_00345)	-	54953..55162 (+)	210	WP_014611912.1	hypothetical protein	-
HHM65_RS00350 (HHM65_00350)	purB	55211..56503 (+)	1293	WP_003056595.1	adenylosuccinate lyase	-
HHM65_RS00355 (HHM65_00355)	comR	56646..57557 (+)	912	WP_003060893.1	XRE family transcriptional regulator	Regulator
HHM65_RS10890	comS	57644..57742 (+)	99	WP_198763767.1	quorum-sensing system DWW-type pheromone	Regulator
HHM65_RS00360 (HHM65_00360)	ruvB	57776..58774 (+)	999	WP_015057190.1	Holliday junction branch migration DNA helicase RuvB	-
HHM65_RS00365 (HHM65_00365)	-	58909..59340 (+)	432	WP_003059365.1	low molecular weight protein-tyrosine-phosphatase	-
HHM65_RS00370 (HHM65_00370)	-	59369..59770 (+)	402	WP_003049089.1	MORN repeat-containing protein	-
HHM65_RS00375 (HHM65_00375)	-	59767..61542 (+)	1776	WP_003059359.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35995.62 Da
• Isoelectric Point: 4.7392

>NTDB_id=439865 HHM65_RS00355 WP_003060893.1 56646..57557(+) (comR) [Streptococcus dysgalactiae subsp. equisimilis strain TPCH-A74]
MLEHFGEKVRGLRLEKGISREELCGDEAELSVRQLARIELGQSIPSLAKVIFIAKALEVSVGYLTDGANLELPKRYKELK
YLILRTPTYMDDRKLQVRESQFDEIFENYYDQLPEEEKIAIDIIQAKFEVYQTGDINFGFNILKEFLPQLKKKTVYNLNE
LLLIDLYLIILVVSNFTNDLFDEEFYKEITERILEQHQYLLLEDLFLLNNILLSCADTSIRLKMFERLKDTLQLSHFIMS
TIQDFQRMPMYCMYEWKLSIFYLKDIKRAETYFSQSLTFTQMTNDSYLAQKLQKEWDKDIHPS

Nucleotide

• Length: 912 bp

>NTDB_id=439865 HHM65_RS00355 WP_003060893.1 56646..57557(+) (comR) [Streptococcus dysgalactiae subsp. equisimilis strain TPCH-A74]
ATGTTAGAGCATTTTGGTGAAAAAGTGAGAGGATTAAGACTTGAGAAAGGGATTAGTCGAGAGGAATTGTGTGGAGATGA
GGCAGAATTGTCTGTTCGCCAGTTGGCGAGGATAGAGCTAGGTCAATCTATACCAAGTTTAGCGAAGGTTATTTTTATTG
CGAAAGCCTTAGAGGTCAGCGTCGGTTATTTGACGGATGGCGCTAACCTAGAACTCCCTAAACGATATAAAGAGTTAAAA
TATCTTATTTTAAGGACTCCGACTTATATGGACGATCGCAAATTACAGGTCCGGGAGTCTCAGTTTGATGAGATATTTGA
AAACTATTATGATCAATTGCCTGAGGAGGAAAAAATAGCGATTGATATTATCCAGGCAAAATTTGAAGTTTATCAGACAG
GTGATATTAATTTTGGTTTTAATATTTTAAAAGAATTTCTACCACAACTAAAAAAGAAAACGGTTTATAACTTAAATGAA
TTATTATTAATTGATTTATATTTAATTATTTTAGTTGTTTCTAACTTTACAAATGACCTATTTGATGAGGAATTTTATAA
AGAAATAACGGAGCGAATCTTAGAACAGCATCAATACCTGTTATTAGAAGATTTATTTCTATTAAATAATATTCTTTTAT
CTTGCGCAGATACTTCTATTCGTTTAAAAATGTTTGAACGACTAAAGGATACGTTACAACTCAGCCATTTTATTATGTCA
ACCATTCAAGATTTTCAGCGAATGCCCATGTATTGCATGTATGAATGGAAATTGTCTATCTTTTATTTAAAAGATATTAA
ACGAGCAGAAACTTATTTTAGTCAATCTCTCACGTTTACTCAAATGACTAATGATAGTTATTTGGCACAAAAGCTTCAAA
AAGAATGGGATAAGGATATTCATCCCTCTTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS315	83.389	99.34	0.828
comR	Streptococcus pyogenes MGAS8232	55.629	99.67	0.554
comR	Streptococcus mutans UA159	46.154	98.68	0.455
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	46.575	96.37	0.449
comR	Streptococcus suis P1/7	37.288	97.36	0.363
comR	Streptococcus suis 05ZYH33	37.288	97.36	0.363