Detailed information    

insolico Bioinformatically predicted

Overview

Name   pknB   Type   Regulator
Locus tag   HB752_RS07045 Genome accession   NZ_CP050271
Coordinates   1431711..1433561 (-) Length   616 a.a.
NCBI ID   WP_019804672.1    Uniprot ID   -
Organism   Streptococcus mutans strain S1     
Function   modulate the activity of ComDE; modulate the activity of VicKR (predicted from homology)   
Competence regulation

Genomic Context

Location: 1426711..1438561
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HB752_RS07020 (HB752_07020) - 1427117..1427503 (-) 387 WP_002263034.1 S1 RNA-binding domain-containing protein -
  HB752_RS07025 (HB752_07025) - 1427487..1428902 (-) 1416 WP_002263035.1 Cof-type HAD-IIB family hydrolase -
  HB752_RS07030 (HB752_07030) - 1428946..1429587 (-) 642 WP_002263036.1 response regulator transcription factor -
  HB752_RS07035 (HB752_07035) - 1429580..1430584 (-) 1005 WP_002263037.1 sensor histidine kinase -
  HB752_RS07040 (HB752_07040) liaF 1430581..1431276 (-) 696 WP_002263038.1 cell wall-active antibiotics response protein LiaF -
  HB752_RS07045 (HB752_07045) pknB 1431711..1433561 (-) 1851 WP_019804672.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  HB752_RS07050 (HB752_07050) - 1433558..1434301 (-) 744 WP_002263040.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  HB752_RS07055 (HB752_07055) rsmB 1434340..1435662 (-) 1323 WP_019804671.1 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB -
  HB752_RS07060 (HB752_07060) fmt 1435643..1436578 (-) 936 WP_002263042.1 methionyl-tRNA formyltransferase -

Sequence

Protein


Download         Length: 616 a.a.        Molecular weight: 66943.75 Da        Isoelectric Point: 9.4520

>NTDB_id=431135 HB752_RS07045 WP_019804672.1 1431711..1433561(-) (pknB) [Streptococcus mutans strain S1]
MIQIGKLFAGRYRILQSIGRGGMADVYLANDLILDNEEVAIKVLRTNYQTDQVAVTRFQREARAMAELNHPNIVAIRDIG
EEDGQQFLAMEYVDGADLKKYIQDHAPLSNAEVIRIMKEVLSAMTLAHQKGIIHRDLKPQNVLLTKDGTAKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATVQSDIYAMGIMLFEMLTGHIPYDGDSAVTIALQHFQKPLPSIIAENKNVP
QALENVVIKATAKRLMDRYHSTQEMLQDLRTSLQPNRSRERKLVFSDASDTKPLPKLEQAAANSLAAQSLKNKTSNQDKV
DHKSKPKTKPQPKPKKKRHFLARFFKIFFILVAIGIAVLTYLVLTKPSTVSVPDVSGDKLSTAKMIIRKSGLKVGDVQKI
EDDNVGAGKVVRTNPSAGSKKREGSSVDIFVASAKGFKMEDYTGQDYKDAIDNLTNNYGVSRDSIVLKEVSSDDYSGGTV
IGQSPKPGKTYHPSSDKKITLKVVKVTMPNLKNSTYEEAVSTLTAMGISSSRIKAYDASDYSSEISSPSSSSLVVGQSPY
YGNTVSLSSNDDIILYVSTSGGSHSGSSSSESSNSEGTTSSEASTDSSSSATTTSH

Nucleotide


Download         Length: 1851 bp        

>NTDB_id=431135 HB752_RS07045 WP_019804672.1 1431711..1433561(-) (pknB) [Streptococcus mutans strain S1]
ATGATTCAGATTGGCAAATTATTTGCTGGTCGTTATCGGATTCTCCAGTCTATCGGACGAGGTGGGATGGCGGATGTTTA
TTTAGCTAATGATTTGATTTTAGATAATGAGGAAGTGGCCATTAAGGTTCTACGTACGAATTATCAGACAGATCAGGTTG
CTGTGACACGTTTTCAGCGGGAAGCACGTGCCATGGCAGAACTTAATCATCCTAATATTGTAGCCATTCGTGACATTGGA
GAAGAAGACGGTCAGCAATTCCTTGCAATGGAATATGTTGATGGCGCCGACTTGAAGAAATACATTCAAGATCACGCTCC
TTTATCAAATGCTGAAGTCATTAGAATCATGAAAGAGGTTCTTTCTGCTATGACTCTTGCCCACCAAAAGGGCATTATTC
ATCGGGATTTAAAACCTCAAAATGTTTTACTGACCAAAGATGGAACGGCTAAAGTAACAGACTTTGGTATTGCTGTGGCT
TTTGCTGAAACGAGTTTGACCCAAACCAATTCAATGCTGGGTTCAGTACATTACTTATCTCCTGAACAGGCGCGTGGTTC
TAAGGCTACTGTTCAAAGTGATATCTATGCAATGGGAATTATGCTTTTTGAAATGCTGACGGGGCATATTCCCTATGATG
GCGATAGTGCTGTTACAATTGCTTTGCAGCATTTTCAAAAGCCTTTACCATCTATTATTGCTGAGAATAAAAATGTCCCT
CAAGCTCTTGAAAATGTTGTTATTAAAGCAACAGCTAAACGATTAATGGACCGCTATCATTCAACGCAGGAGATGTTGCA
GGATTTAAGAACGTCTCTGCAGCCGAATCGCAGCCGTGAAAGAAAGCTTGTTTTCAGTGATGCTTCAGATACAAAACCAC
TACCAAAACTGGAACAGGCAGCAGCAAACTCTTTAGCTGCTCAGTCCTTAAAAAACAAAACTTCCAATCAGGATAAAGTA
GATCATAAATCTAAGCCTAAAACCAAACCACAACCTAAGCCTAAGAAAAAAAGACATTTTTTAGCTCGTTTCTTTAAAAT
CTTCTTTATATTAGTTGCCATTGGTATTGCTGTTTTGACCTACCTGGTTCTGACAAAACCGAGTACTGTTTCAGTTCCTG
ACGTTTCAGGAGATAAATTATCAACGGCCAAGATGATTATTAGAAAATCGGGTCTTAAGGTGGGTGACGTTCAAAAAATT
GAGGATGATAACGTTGGTGCTGGAAAGGTCGTAAGAACTAATCCAAGTGCAGGCAGTAAAAAACGTGAAGGTTCTAGTGT
TGATATTTTTGTAGCTAGTGCTAAGGGATTTAAGATGGAGGACTATACCGGTCAAGATTACAAGGATGCTATTGATAATT
TGACTAATAATTATGGTGTTTCTAGGGACAGTATTGTTCTTAAGGAAGTTTCATCTGATGACTACAGTGGTGGAACTGTT
ATCGGTCAATCACCAAAACCCGGAAAGACCTATCATCCTAGCAGTGATAAAAAAATAACTCTCAAGGTTGTCAAAGTCAC
TATGCCAAATCTTAAAAATTCTACTTATGAAGAGGCTGTCAGTACTTTAACAGCTATGGGGATTTCTTCAAGCCGTATAA
AAGCTTATGATGCCAGCGATTACTCATCAGAAATTTCATCACCATCATCTTCGTCACTCGTTGTCGGTCAAAGTCCTTAT
TATGGTAATACTGTCAGTCTGTCATCTAATGATGATATTATCTTGTATGTTTCAACATCAGGTGGCTCTCATTCTGGTTC
GTCGTCGTCTGAATCTTCGAACAGTGAAGGAACAACATCAAGCGAAGCCTCGACAGACTCTAGTTCAAGTGCGACGACAA
CTTCACATTAA

Domains

Predicted by InterproScan.

Protein kinase domain (Pkinase)

(12-258)

PASTA domain (PASTA)

(370-432)

PASTA domain (PASTA)

(506-579)

PASTA domain (PASTA)

(438-505)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pknB Streptococcus mutans UA159

99.838

100

0.998
  stkP/pknB Streptococcus salivarius strain HSISS4

62.919

96.753

0.609
  stkP Streptococcus pneumoniae TIGR4

52.217

98.864

0.516
  stkP Streptococcus pneumoniae D39

52.053

98.864

0.515
  stkP Streptococcus pneumoniae R6

52.053

98.864

0.515
  stkP Streptococcus pneumoniae Rx1

51.888

98.864

0.513