Detailed information NTG0430533

Bioinformatically predicted

Overview

• Name: comEC/celB
• Type: Machinery gene
• Locus tag: HA248_RS04610
• Genome accession: NZ_CP050175
• Coordinates: 893405..895645 (+)
• Length: 746 a.a.
• NCBI ID: WP_033705318.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain PZ900701590
• Function: ssDNA transport into the cell (predicted from homology) DNA binding and uptake

Genomic Context

Location: 888405..900645

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HA248_RS04565 (HA248_04555)	-	888556..889524 (+)	969	WP_000658183.1	PhoH family protein	-
HA248_RS04575 (HA248_04565)	-	889717..890217 (+)	501	WP_000566988.1	GNAT family N-acetyltransferase	-
HA248_RS04580 (HA248_04570)	-	890220..890545 (+)	326	Protein_902	TfoX/Sxy family protein	-
HA248_RS11460	ald	890846..891957 (-)	1112	Protein_903	alanine dehydrogenase	-
HA248_RS04600 (HA248_04590)	-	892134..892703 (+)	570	WP_001864145.1	GNAT family N-acetyltransferase	-
HA248_RS04605 (HA248_04595)	comEA/celA/cilE	892771..893421 (+)	651	WP_001864147.1	helix-hairpin-helix domain-containing protein	Machinery gene
HA248_RS04610 (HA248_04600)	comEC/celB	893405..895645 (+)	2241	WP_033705318.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
HA248_RS04615 (HA248_04605)	-	895787..896011 (+)	225	WP_015898758.1	hypothetical protein	-
HA248_RS04620 (HA248_04610)	-	896043..896630 (+)	588	WP_000933540.1	ATP-binding cassette domain-containing protein	-
HA248_RS04625 (HA248_04615)	-	896634..897812 (+)	1179	WP_033705319.1	membrane protein	-
HA248_RS04630 (HA248_04620)	infC	898123..898653 (+)	531	WP_000848180.1	translation initiation factor IF-3	-
HA248_RS04635 (HA248_04625)	rpmI	898686..898886 (+)	201	WP_001125943.1	50S ribosomal protein L35	-
HA248_RS04640 (HA248_04630)	rplT	898938..899297 (+)	360	WP_000124836.1	50S ribosomal protein L20	-
HA248_RS04645 (HA248_04635)	-	899355..899735 (+)	381	WP_033705321.1	VOC family protein	-

Sequence

Protein

• Length: 746 a.a.
• Molecular weight: 84448.87 Da
• Isoelectric Point: 9.3992

>NTDB_id=430533 HA248_RS04610 WP_033705318.1 893405..895645(+) (comEC/celB) [Streptococcus pneumoniae strain PZ900701590]
MLQWIKNFSIPLIYLSFLLLWLYYAIFSASYLALLGFVFLLVCLFIQFPWKSAGKVLIICGIFGFWFVFQNWQQSQASQN
LADSVERVRILPDTIKVNGDSLSFRGKSNGRAFQVYYKLQSEEEKEAFQALTDLHEIGLEGKLSEPEGQRNFGGFNYQAY
LKTQGIYQTLNIKTIQSLQKIGSWDIGENLSSLRRKAVVWIKTHFPDPMRNYMTGLLLGHLDTDFEEMNELYSSLGIIHL
FALSGMQVGFFMNGFKKLLLRLGLTQEKLKWLTYPFSLIYAGLTGFSASVIRSLLQKLLAQHGVKGLDNFALTVLVLFIV
MPNFFLTAGGVLSCAYAFILTMTSKEGEGLKAVTSESLVISLGILPILSFYFAEFQPWSILLTFVFSFLFDLVFLPLLSI
LFVLSFLYPVIQLNFIFEWLEGIIRLVSQVASSPLVFGQPNEWLLILLLISLALVYDLRKNIKGLTVLSLLITGLFFLTK
YPLENEITMLDVGQGESIFLRDVTGKTILIDVGGKAESYKKIEKWQEKTTTSNAQRSLIPYLKSRGVAKIDQLILTNTDK
EHVGDLLEVTKAFHVGEILVSKGSLKQKQFVAELQVTQTKVRSMTVGEYLPIFGSQLEVLSPREIGYGGHEDSLVLYGKL
LNNHFLFIGNLEEKGEKDLLKYYPDLKVNVLKASQHGNKKSSSPAFLEKLKPELTLISVGKSNRMKLPHQETLTRLEGIN
SKVYRTDQQGAIRFKGLDSWKIESVR

Nucleotide

• Length: 2241 bp

>NTDB_id=430533 HA248_RS04610 WP_033705318.1 893405..895645(+) (comEC/celB) [Streptococcus pneumoniae strain PZ900701590]
ATGTTACAGTGGATTAAGAATTTCTCTATTCCCCTAATTTACCTGAGTTTTCTATTACTTTGGCTTTATTACGCTATTTT
CTCAGCATCTTATCTTGCTTTGTTGGGCTTTGTTTTTCTGCTAGTCTGTCTCTTTATCCAATTTCCGTGGAAATCTGCTG
GTAAAGTTCTAATAATTTGCGGAATCTTTGGATTTTGGTTTGTTTTTCAAAATTGGCAACAGAGTCAAGCGAGTCAAAAT
CTGGCGGATTCTGTTGAAAGGGTACGGATTTTGCCTGATACTATTAAGGTTAATGGTGATAGTCTATCCTTTCGTGGCAA
GTCTAACGGTCGTGCTTTCCAAGTCTATTATAAACTCCAGTCCGAGGAGGAGAAAGAAGCCTTTCAAGCTTTAACCGACC
TGCATGAGATAGGACTAGAAGGGAAGCTTTCGGAGCCAGAAGGGCAGAGAAATTTTGGTGGCTTTAATTACCAAGCCTAT
CTGAAGACTCAGGGAATTTACCAGACTCTCAATATCAAAACAATCCAGTCACTTCAAAAGATTGGCAGTTGGGATATAGG
AGAAAACTTGTCCAGTTTACGTCGAAAGGCTGTGGTTTGGATTAAGACGCACTTTCCAGACCCTATGCGCAATTACATGA
CAGGACTCTTGCTGGGACATCTGGACACCGACTTTGAGGAGATGAATGAGCTTTATTCGAGTCTAGGAATTATCCACCTC
TTTGCCCTATCTGGTATGCAGGTAGGTTTTTTCATGAATGGATTTAAGAAACTTCTCTTGCGATTGGGCTTGACCCAAGA
AAAGTTGAAATGGCTGACTTATCCCTTTTCCCTTATCTATGCGGGACTAACTGGCTTTTCAGCATCGGTTATTCGCAGTC
TCTTGCAAAAGCTACTGGCTCAACATGGGGTTAAGGGCTTGGATAATTTTGCCTTGACGGTGCTTGTCCTCTTTATTGTC
ATGCCAAACTTTTTCTTGACAGCAGGAGGAGTCTTGTCCTGCGCTTATGCTTTTATCCTGACCATGACCAGCAAAGAAGG
GGAGGGGCTCAAGGCTGTTACTAGTGAAAGTCTAGTCATCTCCTTGGGCATATTGCCCATTCTATCCTTCTATTTTGCGG
AATTTCAACCTTGGTCTATCCTTTTGACCTTTGTCTTTTCCTTTCTTTTTGACTTGGTCTTCTTACCGCTCTTGTCTATC
TTATTTGTCCTTTCCTTTCTCTATCCAGTCATTCAGCTGAACTTTATCTTTGAATGGTTGGAGGGCATTATTCGCTTGGT
GTCACAGGTGGCAAGTAGTCCTCTAGTCTTTGGACAACCCAATGAATGGCTTTTAATCCTATTGTTAATTTCCTTGGCTT
TGGTCTATGATTTGAGGAAAAACATTAAAGGATTAACAGTATTGAGTTTATTGATTACAGGTCTCTTTTTCCTTACCAAG
TATCCACTGGAAAATGAAATCACCATGCTGGATGTGGGGCAAGGAGAAAGTATTTTCCTACGGGATGTAACTGGGAAAAC
CATTCTCATAGATGTAGGTGGTAAGGCAGAATCTTATAAGAAAATCGAAAAATGGCAAGAAAAGACGACGACCAGCAATG
CACAGAGAAGCTTGATACCCTATCTTAAAAGTCGAGGAGTAGCTAAGATTGACCAGCTGATTTTGACAAATACGGACAAG
GAACATGTCGGAGATTTGTTAGAGGTGACCAAGGCTTTCCATGTAGGGGAGATTTTAGTATCAAAAGGCAGTTTGAAGCA
GAAGCAATTTGTGGCAGAACTACAGGTGACTCAAACAAAGGTGCGTAGTATGACAGTAGGGGAGTACTTGCCCATTTTCG
GAAGTCAGTTAGAAGTCCTATCTCCAAGGGAAATTGGATATGGAGGTCATGAAGATTCCCTGGTTCTTTATGGGAAACTC
TTGAATAATCACTTTCTCTTCATAGGAAATTTGGAGGAGAAAGGAGAGAAGGACTTGCTGAAGTACTATCCAGACTTGAA
AGTAAATGTTTTGAAAGCTAGCCAACATGGCAATAAAAAATCATCAAGTCCAGCCTTTCTAGAAAAACTCAAACCAGAGC
TTACTCTTATCTCAGTTGGAAAGAGCAATCGAATGAAACTCCCCCATCAGGAAACATTGACACGACTGGAAGGTATCAAT
AGCAAAGTTTACCGAACTGACCAGCAAGGAGCTATACGCTTTAAGGGGTTGGATAGTTGGAAAATCGAAAGTGTTCGATA
G

Domains

Predicted by InterproScan.

• Domain of unknown function (DUF4131) (DUF4131) (30-176)

• Metallo-beta-lactamase superfamily (Lactamase_B) (492-630)

• Competence protein (Competence) (216-458)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEC/celB	Streptococcus pneumoniae TIGR4	96.649	100	0.966
comEC/celB	Streptococcus pneumoniae Rx1	95.174	100	0.952
comEC/celB	Streptococcus pneumoniae D39	95.174	100	0.952
comEC/celB	Streptococcus pneumoniae R6	95.174	100	0.952
comEC/celB	Streptococcus mitis NCTC 12261	92.081	99.866	0.92
comEC/celB	Streptococcus mitis SK321	91.957	100	0.92
comEC	Lactococcus lactis subsp. cremoris KW2	44.399	99.33	0.441