Detailed information NTG0430523

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: HA248_RS02570
• Genome accession: NZ_CP050175
• Coordinates: 496269..497006 (+)
• Length: 245 a.a.
• NCBI ID: WP_001219122.1
• Uniprot ID: A0A0I5XJR5
• Organism: Streptococcus pneumoniae strain PZ900701590
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 491269..502006

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HA248_RS02535 (HA248_02530)	-	492244..492438 (-)	195	WP_001808905.1	hypothetical protein	-
HA248_RS02540 (HA248_02535)	-	492600..492887 (-)	288	WP_000777753.1	hypothetical protein	-
HA248_RS02545 (HA248_02540)	-	492897..493307 (-)	411	WP_001278301.1	HIT family protein	-
HA248_RS02550 (HA248_02545)	pptA	493375..494106 (+)	732	WP_000889921.1	ABC transporter ATP-binding protein	Regulator
HA248_RS02555 (HA248_02550)	-	494103..495152 (+)	1050	WP_000653771.1	ABC transporter permease	-
HA248_RS02560 (HA248_02555)	-	495320..495649 (-)	330	WP_000132572.1	hypothetical protein	-
HA248_RS02565 (HA248_02560)	-	495926..496264 (+)	339	WP_000682133.1	LytTR family DNA-binding domain-containing protein	-
HA248_RS02570 (HA248_02565)	comE/blpR	496269..497006 (+)	738	WP_001219122.1	LytTR family DNA-binding domain-containing protein	Regulator
HA248_RS02575 (HA248_02570)	-	497019..498359 (+)	1341	WP_000275285.1	sensor histidine kinase	-
HA248_RS02580 (HA248_02575)	blpC	498404..498559 (-)	156	WP_000358814.1	quorum-sensing system pheromone BlpC	-
HA248_RS02585 (HA248_02580)	-	498616..499977 (-)	1362	WP_033705510.1	bacteriocin secretion accessory protein	-
HA248_RS02590 (HA248_02585)	comA/nlmT	499988..501664 (-)	1677	WP_317830619.1	peptide cleavage/export ABC transporter	Regulator

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28766.95 Da
• Isoelectric Point: 6.4140

>NTDB_id=430523 HA248_RS02570 WP_001219122.1 496269..497006(+) (comE/blpR) [Streptococcus pneumoniae strain PZ900701590]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRPHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide

• Length: 738 bp

>NTDB_id=430523 HA248_RS02570 WP_001219122.1 496269..497006(+) (comE/blpR) [Streptococcus pneumoniae strain PZ900701590]
ATGAGAATATTTGTTTTAGAAGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCAGAGGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGACATTGAGATTCGAAATGAGGAGATGAAGGGGCTGGAAGTGGCTAGAAAGATTCGGGATCGGGAC
CCTTATGCCCTAATCGTCTTTGTGACGACTCACTCGGAGTTTATGCCTCTGTCCTTTCGCTACCAAGTGTCAGCTTTGGA
CTACATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGTATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTCCAATATCCTTTCAAAGAGGTTTACTAT
CTCGAAACATCCCCAAGACCCCATCGTGTTATTCTCTATACCAAGACGGACAGGCTAGAATTTACGGCGAGTTTAGAGGA
GGTTTTTAAGCAGGAACCCCGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTCCTTTTCTTTCCCAATGGTGGAAGCTGTCTGATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

3D structure

• AlphaFold DB: A0A0I5XJR5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	53.909	99.184	0.535
comE/comE1	Streptococcus equinus JB1	43.46	96.735	0.42
comE/comE2	Streptococcus equinus JB1	38.43	98.776	0.38