Detailed information NTG0427159

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: G8B37_RS07425
• Genome accession: NZ_CP049695
• Coordinates: 1475312..1477465 (+)
• Length: 717 a.a.
• NCBI ID: WP_011528347.1
• Uniprot ID: A0A660A5H2
• Organism: Streptococcus pyogenes strain ABC76
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 1470312..1482465

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
G8B37_RS07390 (G8B37_07435)	stcA	1470743..1471012 (+)	270	WP_011017467.1	quorum-sensing system protein StcA	-
G8B37_RS07395 (G8B37_07440)	-	1471360..1471758 (-)	399	WP_011528352.1	hypothetical protein	-
G8B37_RS07400 (G8B37_07445)	-	1471851..1472921 (-)	1071	WP_042769789.1	hypothetical protein	-
G8B37_RS07405 (G8B37_07450)	-	1473163..1473573 (-)	411	WP_002985720.1	hypothetical protein	-
G8B37_RS07410 (G8B37_07455)	-	1473767..1474048 (-)	282	WP_011528350.1	hypothetical protein	-
G8B37_RS09550 (G8B37_07460)	-	1474098..1474226 (-)	129	WP_002985724.1	hypothetical protein	-
G8B37_RS07415 (G8B37_07465)	-	1474587..1474784 (-)	198	WP_011528349.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
G8B37_RS07420 (G8B37_07470)	-	1474797..1475024 (-)	228	WP_002992018.1	Blp family class II bacteriocin	-
G8B37_RS07425 (G8B37_07475)	comA/nlmT	1475312..1477465 (+)	2154	WP_011528347.1	peptide cleavage/export ABC transporter	Regulator
G8B37_RS07430 (G8B37_07480)	-	1477476..1478840 (+)	1365	Protein_1421	bacteriocin secretion accessory protein	-
G8B37_RS07435 (G8B37_07485)	-	1478917..1479042 (+)	126	WP_011017462.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
G8B37_RS07440 (G8B37_07490)	-	1479190..1480524 (-)	1335	WP_011528344.1	sensor histidine kinase	-
G8B37_RS07445 (G8B37_07495)	comE/blpR	1480525..1481274 (-)	750	WP_011528343.1	response regulator transcription factor	Regulator

Sequence

Protein

• Length: 717 a.a.
• Molecular weight: 80542.47 Da
• Isoelectric Point: 7.1728

>NTDB_id=427159 G8B37_RS07425 WP_011528347.1 1475312..1477465(+) (comA/nlmT) [Streptococcus pyogenes strain ABC76]
MISYRKTFVAQIDARDCGVAALASIAKYYGSDYSLAHLRELAKTNKEGTTALGIVKAAKLMGFETRAIQADMTLFDIEDV
PYPFIVHVNKEGKFQHYYVVYQNKKNYLIIGDPDPTVKVTKMTKERFTSEWTGVAIFLAPEPSYKPHKDKKNGLINFLPL
IFKQRSLIFYIILASLLVTLINIVGSYYLQGILDDYIPNQLKSTLGIISIGLIITYILQQMMSFSRDYLLTVLSQRLSID
VILSYIRHIFELPMSFFATRRTGEIISRFTDANAIIDALASTILSLFLDVSILTIVGTVLLVQNTNLFLLSLVSVPLYIV
IIFIFMHPFEKMNNDVMQSNSMVSSAIIEDINGIETIKSLTSEENRYQKIDSEFVDYLDKSFKLSKYSILQSSLKQGAQL
ILNVIVLWFGAKLVMGGKISVGQLITFNTLLSYFTNPLENIINLQTKLQSAKVANNRLNEVYLVDSEFQEAGTLVNQELL
HGNIQFEELSYKYGFGRDTLSNINLTIKQGDKVSLVGISGSGKTTLAKMIVNFFEPYNGRITINHNDLKMIDKKSLRQHI
NYLPQQAYIFNGSILENLTLGANDCTSHEDILRACEVAEIRQDIEQMPMGYQTELSDGAGLSGGQKQRIALARALLTKAP
VLILDEATSGLDVLTEKRVIDNLLAMTDKTIIFVAHRLSISARTNQVIVLDEGKIIETGSHQELMTKQGFYHHLFSG

Nucleotide

• Length: 2154 bp

>NTDB_id=427159 G8B37_RS07425 WP_011528347.1 1475312..1477465(+) (comA/nlmT) [Streptococcus pyogenes strain ABC76]
ATGATATCCTATCGAAAAACATTTGTTGCTCAGATTGATGCTAGAGACTGTGGTGTGGCTGCTCTTGCTTCCATCGCTAA
ATATTACGGTTCAGACTACTCTTTAGCTCATTTAAGAGAGTTAGCTAAAACAAATAAAGAGGGAACAACAGCGCTTGGCA
TCGTCAAAGCTGCCAAATTAATGGGGTTTGAAACAAGAGCTATTCAAGCAGACATGACCCTCTTTGATATAGAAGATGTC
CCTTATCCTTTTATTGTTCATGTTAATAAAGAAGGTAAATTCCAACACTACTATGTCGTCTATCAAAACAAAAAAAATTA
TCTGATAATCGGCGACCCTGACCCGACAGTAAAAGTCACTAAGATGACAAAGGAGCGATTTACTTCTGAATGGACGGGTG
TCGCTATTTTTCTAGCACCCGAGCCCAGCTACAAGCCTCATAAGGACAAAAAGAACGGTCTAATAAACTTTTTACCTCTT
ATTTTTAAACAGCGATCTCTGATTTTCTATATCATATTAGCTAGCCTACTCGTTACTCTGATTAATATTGTAGGTTCTTA
TTACCTACAAGGTATATTAGATGACTATATTCCAAATCAACTGAAATCAACACTCGGCATTATTTCAATTGGTCTTATCA
TTACCTATATCCTCCAACAGATGATGAGTTTTTCGCGAGATTATCTCCTGACTGTACTGAGTCAGCGATTAAGCATTGAC
GTCATTTTATCTTACATTCGCCATATTTTTGAATTACCCATGTCTTTTTTTGCAACTCGCAGAACAGGAGAAATCATTTC
ACGGTTTACAGATGCTAATGCTATTATTGATGCACTCGCTTCTACTATTTTGTCTCTTTTTCTTGATGTCAGTATTTTAA
CTATCGTAGGGACAGTCCTGTTAGTGCAAAATACCAATCTTTTTCTTCTATCTCTGGTTTCAGTCCCTCTATATATTGTT
ATTATCTTTATATTTATGCACCCATTTGAAAAGATGAATAATGATGTCATGCAGAGTAACTCTATGGTTAGCTCAGCCAT
TATCGAAGATATCAATGGCATTGAAACTATTAAATCACTGACCAGTGAAGAAAATCGTTATCAGAAAATTGATAGTGAAT
TTGTGGACTATCTGGATAAATCTTTCAAGTTAAGTAAGTACTCTATTTTACAAAGCAGTCTCAAACAAGGGGCGCAACTA
ATCCTTAACGTGATAGTCTTATGGTTTGGGGCCAAATTAGTTATGGGAGGAAAAATTTCTGTTGGTCAGTTGATTACGTT
TAATACTCTCTTATCTTATTTTACCAATCCTTTAGAAAATATCATTAATCTTCAAACCAAACTTCAATCAGCCAAGGTAG
CTAATAATCGTCTCAATGAAGTTTACCTAGTCGATTCTGAATTTCAAGAGGCTGGGACATTAGTCAATCAAGAATTATTA
CACGGAAACATTCAATTTGAAGAGTTATCCTATAAATATGGCTTTGGACGCGATACTCTATCAAATATTAATCTCACTAT
TAAGCAAGGGGACAAAGTTAGCCTTGTTGGTATTAGTGGATCTGGTAAAACGACTCTAGCTAAAATGATTGTTAATTTTT
TTGAGCCTTATAACGGCCGAATTACCATTAATCATAATGACTTAAAAATGATTGATAAAAAAAGTCTTCGCCAACATATT
AATTATCTCCCCCAACAAGCCTATATTTTTAATGGTTCTATTTTAGAAAATTTAACCTTAGGTGCTAATGACTGTACTAG
TCATGAAGATATTCTAAGAGCTTGTGAGGTTGCAGAAATTCGACAAGATATTGAACAAATGCCTATGGGCTATCAAACAG
AGCTTTCTGATGGTGCCGGACTCTCAGGAGGCCAAAAGCAACGAATTGCGCTTGCCAGAGCTCTCCTAACCAAGGCGCCT
GTGCTTATTCTAGATGAGGCTACAAGCGGTCTTGACGTACTAACTGAAAAGAGGGTTATTGATAATCTTTTGGCTATGAC
GGATAAAACTATTATTTTCGTAGCTCATCGTCTCAGCATTTCAGCGCGGACCAATCAAGTCATTGTGCTTGATGAGGGCA
AAATTATTGAAACAGGATCTCATCAAGAATTAATGACTAAACAAGGTTTCTATCATCATTTATTTAGTGGTTAA

Domains

Predicted by InterproScan.

• ABC transporter transmembrane region (ABC_membrane) (168-438)

• ABC transporter (ABC_tran) (500-649)

• Peptidase C39 family (Peptidase_C39) (7-142)

3D structure

• AlphaFold DB: A0A660A5H2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	72.867	99.721	0.727
comA	Streptococcus mitis NCTC 12261	67.511	99.163	0.669
comA	Streptococcus mitis SK321	67.229	99.163	0.667
comA	Streptococcus pneumoniae Rx1	67.089	99.163	0.665
comA	Streptococcus pneumoniae D39	67.089	99.163	0.665
comA	Streptococcus pneumoniae R6	67.089	99.163	0.665
comA	Streptococcus pneumoniae TIGR4	66.807	99.163	0.662
comA	Streptococcus gordonii str. Challis substr. CH1	66.014	99.721	0.658