Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   ST64987_RS01675 Genome accession   NZ_CP049053
Coordinates   299210..299899 (+) Length   229 a.a.
NCBI ID   WP_002949638.1    Uniprot ID   A0A060BFD8
Organism   Streptococcus thermophilus strain ST64987     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 294210..304899
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ST64987_RS10070 - 295176..295346 (+) 171 Protein_265 ascorbate 6-phosphate lactonase -
  ST64987_RS01655 (ST64987_0292) - 295363..296034 (-) 672 WP_064355629.1 TrkA family potassium uptake protein -
  ST64987_RS01660 (ST64987_0293) - 296074..297438 (-) 1365 WP_081247984.1 TrkH family potassium uptake protein -
  ST64987_RS01665 (ST64987_0294) rsmG 297508..298221 (-) 714 WP_100273329.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  ST64987_RS01670 (ST64987_0295) - 298518..299054 (+) 537 WP_100273690.1 DUF177 domain-containing protein -
  ST64987_RS01675 (ST64987_0296) covR 299210..299899 (+) 690 WP_002949638.1 response regulator transcription factor Regulator
  ST64987_RS01680 (ST64987_0297) covS 299896..301413 (+) 1518 WP_167401421.1 HAMP domain-containing histidine kinase Regulator
  ST64987_RS01685 (ST64987_0298) nrdR 301536..302015 (+) 480 WP_002949642.1 transcriptional regulator NrdR -
  ST64987_RS01690 (ST64987_0299) - 302012..303187 (+) 1176 WP_167401422.1 DnaD domain protein -
  ST64987_RS01695 (ST64987_0300) dnaI 303191..304093 (+) 903 WP_002946786.1 primosomal protein DnaI -

Sequence

Protein


Download         Length: 229 a.a.        Molecular weight: 26655.77 Da        Isoelectric Point: 4.7059

>NTDB_id=424460 ST64987_RS01675 WP_002949638.1 299210..299899(+) (covR) [Streptococcus thermophilus strain ST64987]
MSKRILIVEDERNLARFVSLELQHEGYDVVTADNGREGLEMALEKDFDLILLDLMLPEMDGFEVTRRLQQEKDTYIMMMT
ARDSIMDIVAGLDRGADDYIIKPFAIEELLARIRATFRRQDIEATKKAPAKASTYRDLKLDVQNRAVVRGDEVIPLTKRE
FDLLNTLLSNMNQVMTREELLLQVWKYDDVIETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIRER

Nucleotide


Download         Length: 690 bp        

>NTDB_id=424460 ST64987_RS01675 WP_002949638.1 299210..299899(+) (covR) [Streptococcus thermophilus strain ST64987]
ATGAGCAAACGCATTTTGATTGTTGAAGATGAGAGAAACCTTGCTCGTTTTGTCTCTCTTGAACTTCAACACGAAGGATA
CGACGTTGTGACAGCGGACAACGGACGCGAAGGACTTGAAATGGCACTTGAGAAAGATTTCGATCTTATTCTCTTGGACC
TTATGTTGCCTGAGATGGACGGTTTCGAAGTGACACGTCGTCTCCAACAAGAAAAAGATACATATATTATGATGATGACA
GCTCGCGACTCAATCATGGATATTGTTGCTGGTTTGGATCGTGGAGCTGATGACTATATTATAAAACCATTTGCGATTGA
AGAACTGTTGGCACGTATTCGTGCAACCTTCCGTCGTCAAGATATCGAAGCTACTAAGAAGGCACCAGCTAAAGCGTCAA
CCTATCGCGATTTAAAATTGGATGTTCAAAACCGTGCAGTTGTTCGCGGTGATGAGGTAATTCCATTGACAAAACGTGAG
TTTGATTTGTTGAACACACTTTTAAGCAATATGAACCAAGTAATGACCCGTGAGGAACTCTTGCTTCAAGTCTGGAAATA
TGATGACGTAATTGAAACAAACGTTGTAGATGTTTATATTCGTTACTTACGTGGGAAAATCGACATTCCAGGTAAGGAAT
CATACATTCAAACAGTACGAGGGATGGGTTACGTTATCCGTGAAAGATGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(152-225)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A060BFD8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

96.07

100

0.961
  covR Lactococcus lactis subsp. lactis strain DGCC12653

67.544

99.563

0.672
  vicR Streptococcus mutans UA159

45.259

100

0.459
  micA Streptococcus pneumoniae Cp1015

43.913

100

0.441