Detailed information NTG0418262

Bioinformatically predicted

Overview

• Name: comEC/celB
• Type: Machinery gene
• Locus tag: M594_RS06490
• Genome accession: NZ_CP047883
• Coordinates: 1316842..1319082 (-)
• Length: 746 a.a.
• NCBI ID: WP_173876287.1
• Uniprot ID: A0A6M9F6C2
• Organism: Streptococcus mitis strain S022-V3-A4
• Function: ssDNA transport into the cell (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1311842..1324082

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
M594_RS06460 (M594_06480)	-	1312747..1313127 (-)	381	WP_000157153.1	VOC family protein	-
M594_RS06465 (M594_06485)	rplT	1313186..1313545 (-)	360	WP_000124834.1	50S ribosomal protein L20	-
M594_RS06470 (M594_06490)	rpmI	1313597..1313797 (-)	201	WP_001125943.1	50S ribosomal protein L35	-
M594_RS06475 (M594_06495)	infC	1313830..1314360 (-)	531	WP_000848180.1	translation initiation factor IF-3	-
M594_RS06480 (M594_06500)	-	1314668..1315852 (-)	1185	WP_173876285.1	hypothetical protein	-
M594_RS06485 (M594_06505)	-	1315856..1316443 (-)	588	WP_173876286.1	ATP-binding cassette domain-containing protein	-
M594_RS10130	-	1316476..1316700 (-)	225	WP_254597133.1	hypothetical protein	-
M594_RS06490 (M594_06510)	comEC/celB	1316842..1319082 (-)	2241	WP_173876287.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
M594_RS06495 (M594_06515)	comEA/celA/cilE	1319066..1319713 (-)	648	WP_173876288.1	helix-hairpin-helix domain-containing protein	Machinery gene
M594_RS06500 (M594_06520)	-	1319780..1320349 (-)	570	WP_153209672.1	GNAT family N-acetyltransferase	-
M594_RS06505 (M594_06525)	ald	1320521..1321633 (+)	1113	WP_173876289.1	alanine dehydrogenase	-
M594_RS06510 (M594_06530)	-	1321690..1322685 (-)	996	WP_125447093.1	PhoH family protein	-
M594_RS06515 (M594_06535)	-	1322770..1322985 (-)	216	WP_049488667.1	YozE family protein	-
M594_RS06520 (M594_06540)	-	1323031..1323588 (-)	558	WP_173876290.1	GrpB family protein	-

Sequence

Protein

• Length: 746 a.a.
• Molecular weight: 84793.11 Da
• Isoelectric Point: 9.1835

>NTDB_id=418262 M594_RS06490 WP_173876287.1 1316842..1319082(-) (comEC/celB) [Streptococcus mitis strain S022-V3-A4]
MLQWIKNFPLPLIYLSFLLLWIYYAIFSSSYLALLGFVFLLVCLFFQFPWKSASKVLVICGIFGFWFLFQNWQQSQASQN
LADSVERVRILPDTIKVNGDSLSFRGKSDGRIFQVYYKLQSEEEKETFQILTALHDLELEGKLSEPEGKRNFGGFDYQAY
LKTQGIYQTLNIKKIQSLQKVGSWDLGENLSSLRRKAVVWIKTHFPDPMRNYMTGLLLGHLDTDFEEMNELYSSLGIIHL
FALSGMQVGFFMDGFKKLLLRLGLTQEKLKWLTYPFSLIYAGLTGFSASVIRSLLQKLLAQHGVKGLDNFALTVLVLFII
MPNFFLTAGGVLSCAYAFILTMTSKEGDGLKAVARESLVISLGILPILSFYFAEFQPWSILLTFVFSFLFDLVFLPLLSI
LFVLSFLYPVIQLNFIFEWLEGIIRLVSQVASRPLVFGQPNAWLLILLLISLALVYDLRKNIKRLAVLSLLVTGLFFLTK
HPLENEITMLDVGQGESIFLRDVTGKTILIDVGGKAESDKKIEKWQEKATTSNAQRTLIPYLKNRGVAKIDQLILTNTDK
EHVGDLLEVTKAFHVGEILVSKGSLKQKEFVAELQATQTKVRSITAGENLPIFGSQLEVQFPRKIGDGDHEDSLVLYGKL
LDKNFLFTGNLEEKGEKELLRQYPDLEVDVLKAGQHGSKNSSSSAFLEQLKPEMTLISVGKNNRTKLPHQETLIRLEDIN
SKVYRTDQQGAIRFKGWKNWKIESVR

Nucleotide

• Length: 2241 bp

>NTDB_id=418262 M594_RS06490 WP_173876287.1 1316842..1319082(-) (comEC/celB) [Streptococcus mitis strain S022-V3-A4]
ATGTTACAGTGGATTAAGAATTTCCCCCTTCCCCTAATTTATCTGAGTTTTCTATTGCTCTGGATTTACTACGCCATTTT
CTCATCATCTTATCTCGCACTGCTAGGCTTTGTTTTTCTACTAGTCTGTCTCTTTTTCCAATTTCCTTGGAAATCTGCTA
GCAAAGTTCTAGTGATTTGTGGAATCTTTGGCTTCTGGTTTCTGTTTCAAAATTGGCAACAGAGTCAAGCGAGTCAAAAT
TTGGCGGATTCTGTTGAAAGGGTACGGATTTTGCCCGACACTATTAAGGTTAATGGTGATAGTCTATCCTTTCGTGGCAA
GTCTGATGGACGCATTTTTCAAGTCTATTATAAACTCCAATCCGAGGAGGAGAAAGAAACCTTTCAAATTTTAACAGCCC
TTCATGATTTGGAACTAGAAGGGAAACTTTCGGAGCCAGAAGGGAAGAGAAATTTTGGTGGTTTTGACTATCAAGCCTAT
CTGAAAACTCAGGGAATTTACCAGACTCTGAATATCAAAAAAATCCAGTCACTTCAAAAGGTTGGCAGTTGGGATCTAGG
TGAAAACCTGTCCAGTTTACGCCGTAAGGCTGTAGTTTGGATTAAGACGCATTTTCCAGATCCTATGCGCAATTACATGA
CGGGGCTTCTATTAGGACATCTGGATACAGACTTTGAGGAGATGAATGAGCTTTATTCTAGTCTAGGAATTATCCACCTA
TTTGCCTTGTCAGGCATGCAGGTAGGATTTTTCATGGATGGATTTAAGAAACTACTCTTGCGATTAGGCTTGACCCAAGA
AAAGTTGAAATGGCTGACTTATCCCTTTTCCCTTATCTATGCAGGGCTGACAGGATTTTCAGCATCGGTCATTCGCAGTC
TCTTGCAAAAGTTACTGGCTCAACATGGTGTTAAGGGTTTGGATAATTTTGCCTTGACGGTTCTTGTCCTCTTTATCATC
ATGCCAAACTTTTTCTTGACAGCAGGAGGAGTCTTATCCTGCGCTTATGCTTTTATCTTGACCATGACCAGCAAAGAAGG
GGATGGGCTCAAGGCTGTTGCTAGAGAAAGTCTAGTCATTTCCTTGGGAATATTGCCCATTCTGTCCTTCTATTTTGCGG
AATTTCAACCTTGGTCCATCCTCTTGACCTTTGTCTTTTCCTTTCTTTTTGACTTGGTCTTCTTACCGCTCTTGTCTATC
TTATTTGTCCTTTCTTTTCTCTATCCAGTCATTCAGCTGAATTTTATTTTTGAATGGTTGGAGGGAATAATTCGCTTGGT
ATCACAGGTGGCAAGTAGACCGCTTGTCTTTGGACAACCTAATGCGTGGCTTTTAATTTTATTGTTAATTTCCTTGGCTT
TAGTCTATGATTTGAGGAAAAACATTAAAAGGCTAGCAGTATTGAGCTTATTGGTTACAGGTCTCTTTTTCCTTACCAAG
CATCCACTGGAAAATGAAATTACCATGCTAGATGTTGGGCAAGGCGAAAGTATTTTCCTACGGGATGTAACTGGGAAAAC
CATTCTCATAGATGTGGGAGGTAAGGCAGAGTCTGATAAGAAAATTGAAAAATGGCAAGAAAAGGCGACAACCAGCAATG
CCCAGCGAACCTTGATACCCTATCTCAAAAATAGAGGAGTAGCCAAGATTGACCAGCTGATTTTGACAAATACGGACAAG
GAACATGTCGGAGATTTGTTAGAGGTGACCAAGGCTTTCCATGTAGGGGAGATCTTAGTATCAAAAGGAAGTTTGAAACA
GAAGGAATTTGTGGCAGAACTACAAGCGACCCAAACAAAAGTTAGAAGTATAACAGCAGGAGAGAACTTGCCAATTTTTG
GAAGTCAGTTAGAAGTCCAATTTCCAAGGAAAATTGGAGATGGAGATCATGAAGATTCCCTGGTTTTGTATGGAAAACTC
TTGGATAAAAACTTTCTTTTCACAGGAAATTTGGAGGAAAAAGGAGAGAAGGAATTGCTGAGGCAATATCCTGACCTAGA
AGTGGATGTTTTGAAAGCTGGTCAACATGGCTCTAAAAACTCATCAAGTTCAGCCTTTTTAGAACAGCTCAAACCAGAGA
TGACCCTCATCTCAGTTGGAAAGAACAATCGAACGAAACTCCCCCATCAGGAAACCTTGATACGACTAGAAGATATCAAT
AGCAAAGTTTACCGAACTGATCAGCAAGGAGCTATACGCTTTAAAGGGTGGAAAAATTGGAAAATCGAAAGTGTTCGATA
G

Domains

Predicted by InterproScan.

• Competence protein (Competence) (216-458)

• Metallo-beta-lactamase superfamily (Lactamase_B) (492-691)

• Domain of unknown function (DUF4131) (DUF4131) (29-177)

3D structure

• AlphaFold DB: A0A6M9F6C2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEC/celB	Streptococcus mitis SK321	94.638	100	0.946
comEC/celB	Streptococcus mitis NCTC 12261	92.349	99.866	0.922
comEC/celB	Streptococcus pneumoniae TIGR4	90.885	100	0.909
comEC/celB	Streptococcus pneumoniae D39	90.483	100	0.905
comEC/celB	Streptococcus pneumoniae Rx1	90.483	100	0.905
comEC/celB	Streptococcus pneumoniae R6	90.483	100	0.905
comEC	Lactococcus lactis subsp. cremoris KW2	44.669	99.33	0.444