Detailed information NTG0418244

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: M594_RS01980
• Genome accession: NZ_CP047883
• Coordinates: 392298..393035 (+)
• Length: 245 a.a.
• NCBI ID: WP_173875830.1
• Uniprot ID: -
• Organism: Streptococcus mitis strain S022-V3-A4
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 387298..398035

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
M594_RS01950 (M594_01975)	dnaJ	387642..388778 (+)	1137	WP_136936942.1	molecular chaperone DnaJ	-
M594_RS01955 (M594_01980)	-	389058..389345 (-)	288	WP_000777752.1	hypothetical protein	-
M594_RS01960 (M594_01985)	-	389355..389765 (-)	411	WP_001278317.1	HIT family protein	-
M594_RS01965 (M594_01990)	pptA	389833..390564 (+)	732	WP_050251578.1	ABC transporter ATP-binding protein	Regulator
M594_RS01970 (M594_01995)	-	390561..391610 (+)	1050	WP_173875829.1	ABC transporter permease	-
M594_RS01975 (M594_02000)	-	391673..392002 (-)	330	WP_084947397.1	helicase BlpT	-
M594_RS01980 (M594_02005)	comE/blpR	392298..393035 (+)	738	WP_173875830.1	response regulator transcription factor	Regulator
M594_RS01985 (M594_02010)	-	393049..394398 (+)	1350	WP_173875831.1	sensor histidine kinase	-
M594_RS01990 (M594_02015)	-	394467..394823 (+)	357	WP_120719177.1	hypothetical protein	-
M594_RS10085	-	395144..395224 (+)	81	WP_419991826.1	hypothetical protein	-
M594_RS01995 (M594_02025)	-	395679..396083 (+)	405	WP_020903123.1	hypothetical protein	-
M594_RS02000 (M594_02030)	blpZ	396129..396377 (+)	249	WP_000276505.1	immunity protein BlpZ	-
M594_RS02005 (M594_02035)	-	396407..397018 (+)	612	WP_173875832.1	CPBP family intramembrane glutamic endopeptidase	-
M594_RS02010 (M594_02040)	ccrZ	397180..397974 (+)	795	WP_173875833.1	cell cycle regulator CcrZ	-

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28805.94 Da
• Isoelectric Point: 6.3073

>NTDB_id=418244 M594_RS01980 WP_173875830.1 392298..393035(+) (comE/blpR) [Streptococcus mitis strain S022-V3-A4]
MRIFVLEDDFSQQARIETTIEKLLKEHHITPSSFEVFGKPDQLLTEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRAHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVRLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide

• Length: 738 bp

>NTDB_id=418244 M594_RS01980 WP_173875830.1 392298..393035(+) (comE/blpR) [Streptococcus mitis strain S022-V3-A4]
ATGAGAATATTTGTTTTAGAAGATGATTTTTCCCAACAGGCTAGGATTGAAACGACGATTGAGAAACTCTTGAAGGAGCA
TCATATCACTCCGAGTTCTTTTGAAGTCTTTGGTAAGCCAGATCAACTGCTGACAGAGGTGCATGAGAAGGGAGCTCATC
AACTATTCTTTTTGGATATTGAGATTCGAAATGAGGAGATGAAGGGGTTGGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCGTATGCCCTGATTGTCTTTGTGACGACTCACTCAGAGTTCATGCCCCTGTCCTTTCGCTACCAAGTGTCTGCTTTGGA
CTACATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGTATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGACA
GTAAGAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAGTTTCAGTATCCTTTTAAAGAGGTTTATTAT
CTTGAAACATCGCCCAGAGCCCATCGTGTTATTCTCTATACCAAGACGGACAGGCTGGAATTTACAGCGAGTTTGGAGGA
GGTTTTCAAGCAGGAGCCTCGCCTCTTGCAGTGCCACCGCTCTTTTCTCATCAATCCTGCCAATGTGGTGCGTTTGGATA
AGAAAGAAAAACTCCTTTTCTTTCCCAATGGTGGGAGCTGTCTGATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAAGCT
ATCAATAACTTACATTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	55.144	99.184	0.547
comE/comE1	Streptococcus equinus JB1	43.46	96.735	0.42
comE/comE2	Streptococcus equinus JB1	39.256	98.776	0.388
comE	Streptococcus infantis strain Atu-4	36.179	100	0.363