Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   GU333_RS00610 Genome accession   NZ_CP047630
Coordinates   110989..112236 (-) Length   415 a.a.
NCBI ID   WP_138492203.1    Uniprot ID   -
Organism   Lactococcus raffinolactis strain Lr_18_12S     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 105989..117236
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  GU333_RS00575 (GU333_00575) - 106484..107230 (+) 747 WP_061775130.1 tRNA1(Val) (adenine(37)-N6)-methyltransferase -
  GU333_RS00580 (GU333_00580) - 107223..107513 (+) 291 WP_061775129.1 GIY-YIG nuclease family protein -
  GU333_RS00585 (GU333_00585) - 107574..107798 (-) 225 WP_061775128.1 DUF1797 family protein -
  GU333_RS00590 (GU333_00590) - 107859..109190 (-) 1332 WP_138492204.1 glycosyltransferase family 4 protein -
  GU333_RS00595 (GU333_00595) - 109290..110288 (-) 999 WP_061775126.1 glycosyltransferase -
  GU333_RS00605 (GU333_00605) - 110697..110948 (+) 252 WP_167841738.1 hypothetical protein -
  GU333_RS00610 (GU333_00610) htrA 110989..112236 (-) 1248 WP_138492203.1 trypsin-like peptidase domain-containing protein Regulator
  GU333_RS00615 (GU333_00615) rlmH 112533..113009 (+) 477 WP_096039856.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  GU333_RS00620 (GU333_00620) - 113006..113668 (+) 663 WP_138492202.1 DNA alkylation repair protein -
  GU333_RS00625 (GU333_00625) - 113733..114410 (+) 678 WP_061775121.1 YoaK family protein -
  GU333_RS00630 (GU333_00630) - 114513..115511 (+) 999 WP_001048115.1 IS5-like element IS1194 family transposase -

Sequence

Protein


Download         Length: 415 a.a.        Molecular weight: 43477.83 Da        Isoelectric Point: 5.3584

>NTDB_id=414715 GU333_RS00610 WP_138492203.1 110989..112236(-) (htrA) [Lactococcus raffinolactis strain Lr_18_12S]
MKNSKKTAVKLIAAGIIGGVVSLGGNIAYDHFTGDTPIKTNQTSTTKVSDVSYKVSSSTTKAIAKVSDAIVSVINYQKAS
SSNSLDDLFGDSSSTNKDNAKEQPAGEGSGVIYKKDGDYAYIVTNNHVVDGASSLEIMLSNGNKVKGTLVGKDAYSDLAV
IKIPSKEVTKVAEFGDSSKLTVGEPAIAIGSPLGSEYANSATEGIISSLSRKVIMQNESNETVNVNAIQTDAAINPGNSG
GALINVEGQVIGINSSKISATGSSSRDVSVEGMGFAIPSNDVVEIISKLEKDGEIKRPALGVQMVDLTGINSRYIDELKL
PDSVTAGVVVAKVQKGLPADTAGLKKYDVITKIGDTKVTTSTELQSALYKYNVGDEMKVTYYREGKEKTATVKLATSSDK
LDFKDAESAKAEQDK

Nucleotide


Download         Length: 1248 bp        

>NTDB_id=414715 GU333_RS00610 WP_138492203.1 110989..112236(-) (htrA) [Lactococcus raffinolactis strain Lr_18_12S]
ATGAAAAATAGTAAAAAAACTGCTGTAAAATTAATCGCTGCTGGGATTATCGGTGGTGTTGTTTCATTAGGTGGTAATAT
CGCCTACGACCATTTTACGGGTGATACGCCTATCAAGACGAATCAAACCAGCACGACCAAAGTGTCTGATGTTTCTTATA
AAGTATCAAGTAGTACGACTAAAGCGATTGCCAAAGTATCTGATGCCATTGTCTCTGTCATTAATTATCAAAAAGCGTCG
TCAAGCAACTCATTAGATGATCTTTTTGGTGATAGCTCATCTACTAATAAGGATAATGCTAAAGAACAACCCGCAGGTGA
AGGCTCTGGTGTCATCTATAAAAAAGACGGTGATTACGCTTATATCGTTACCAACAACCACGTCGTTGATGGTGCAAGCT
CACTAGAAATCATGCTATCAAATGGTAATAAGGTCAAAGGTACTTTAGTCGGGAAAGATGCTTATAGCGATTTAGCGGTC
ATTAAAATTCCATCTAAAGAAGTCACAAAAGTTGCTGAATTCGGCGATTCTTCCAAGCTTACTGTTGGAGAGCCCGCCAT
TGCTATCGGCTCTCCTCTAGGAAGTGAATATGCTAACTCAGCCACTGAAGGGATTATCTCTAGTCTATCACGCAAGGTTA
TCATGCAAAATGAAAGCAATGAAACCGTCAATGTTAATGCCATTCAAACCGATGCCGCGATTAATCCCGGCAACTCTGGT
GGTGCTTTGATCAACGTCGAAGGTCAAGTCATCGGCATCAACTCAAGCAAGATCTCTGCAACAGGTTCATCTTCAAGAGA
TGTTTCTGTTGAAGGGATGGGCTTCGCCATTCCATCCAATGATGTCGTTGAAATTATCAGTAAACTCGAAAAAGACGGTG
AAATCAAGCGCCCAGCACTCGGCGTGCAAATGGTTGATCTCACTGGCATTAACTCGCGCTATATCGACGAGCTCAAACTT
CCTGACTCTGTCACAGCAGGTGTCGTGGTCGCCAAAGTTCAAAAAGGTCTACCAGCCGACACTGCGGGACTTAAAAAATA
TGATGTGATCACGAAAATTGGTGATACTAAAGTGACAACTAGTACTGAACTTCAAAGCGCGCTTTACAAATACAATGTCG
GAGACGAGATGAAAGTCACTTACTACCGTGAGGGTAAAGAAAAAACAGCAACTGTTAAACTTGCTACATCCTCTGATAAG
TTAGACTTTAAAGATGCTGAGTCTGCCAAGGCTGAACAAGATAAATAA

Domains

Predicted by InterproScan.

Trypsin-like peptidase domain (Trypsin_2)

(108-253)

Peptidase family M50 (Peptidase_M50)

(265-398)

PDZ domain (PDZ_2)

(298-394)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

56.127

98.313

0.552
  htrA Streptococcus mutans UA159

56.633

94.458

0.535
  htrA Streptococcus mitis NCTC 12261

51.741

96.867

0.501
  htrA Streptococcus pneumoniae Rx1

55.211

85.542

0.472
  htrA Streptococcus pneumoniae D39

55.211

85.542

0.472
  htrA Streptococcus pneumoniae R6

55.211

85.542

0.472
  htrA Streptococcus pneumoniae TIGR4

55.211

85.542

0.472

Multiple sequence alignment