Detailed information NTG0041367

Bioinformatically predicted

Overview

• Name: comEC/celB
• Type: Machinery gene
• Locus tag: HMPREF0833_RS00915
• Genome accession: NC_015678
• Coordinates: 172039..174285 (+)
• Length: 748 a.a.
• NCBI ID: WP_013903298.1
• Uniprot ID: F8DFD0
• Organism: Streptococcus parasanguinis ATCC 15912
• Function: ssDNA transport into the cell (predicted from homology) DNA binding and uptake

Genomic Context

Location: 167039..179285

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HMPREF0833_RS00895 (HMPREF0833_10170)	-	167501..168031 (+)	531	WP_013903294.1	DUF4352 domain-containing protein	-
HMPREF0833_RS00900 (HMPREF0833_10171)	-	168063..170402 (-)	2340	WP_013903295.1	cation-translocating P-type ATPase	-
HMPREF0833_RS00905 (HMPREF0833_10172)	-	170577..171323 (+)	747	WP_013903296.1	1-acyl-sn-glycerol-3-phosphate acyltransferase	-
HMPREF0833_RS00910 (HMPREF0833_10173)	comEA/celA/cilE	171390..172058 (+)	669	WP_013903297.1	helix-hairpin-helix domain-containing protein	Machinery gene
HMPREF0833_RS00915 (HMPREF0833_10174)	comEC/celB	172039..174285 (+)	2247	WP_013903298.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
HMPREF0833_RS00920 (HMPREF0833_10175)	-	174361..174963 (+)	603	WP_003017728.1	DUF805 domain-containing protein	-
HMPREF0833_RS00925 (HMPREF0833_10176)	holA	174987..176021 (+)	1035	WP_013903299.1	DNA polymerase III subunit delta	-
HMPREF0833_RS00930 (HMPREF0833_10177)	sodA	176109..176714 (+)	606	WP_003017685.1	superoxide dismutase SodA	-
HMPREF0833_RS00935 (HMPREF0833_10178)	-	176926..178395 (+)	1470	WP_003017749.1	helicase HerA-like domain-containing protein	-

Sequence

Protein

• Length: 748 a.a.
• Molecular weight: 85680.16 Da
• Isoelectric Point: 9.0968

>NTDB_id=41367 HMPREF0833_RS00915 WP_013903298.1 172039..174285(+) (comEC/celB) [Streptococcus parasanguinis ATCC 15912]
MLSRWIKDLPFSLVHLAFLLLWLYFSVYQPSWLSISGLVVVVVLAVHHYKGDRSSLLGLALATLCFAAFFVFHRIQDHPV
QAESQPPSHLLLIPDTIKINGDALSFRAKNQGRTYQVFYTLKSEKEKQQWQSQTHLLELTYKGVIEEPEGQRNFRGFDYR
SYLQTQGIHYQIKIEAIQSALPIQTWNVFDCLSQWRRQAIVWSKEHFPQPMNQYMTGLLFGYLDTDFEEMDQLYTSLGII
HLFALSGMQVGFFINGIRKALLRLGILQETVDIWMVPISLVYAGLTGFSVSVVRSLLQKILSQKGIRGMENMAMTLMLLM
LLMPKFLLTAGGVLSCAYAFILTLVDTSSYSGLKKLLVESFWISLGILPLLTYYFSVFQPWSLPLTFLFSFLFDLVLLPG
LTVLFILSILKPLTIFNSFFLLIEECIRWISKLTSLPLVFGQPTGPALIALFLLLGILYDFRKQKKRRFLLIGMILLIFC
WTKHPLENEITMVDIGQGDSIFLRDWKGRTILIDVGGRVTFKSGDKWQERSQSANADQTLIPYLKSRGVGKLDALVLTHT
DQDHMGDMLEVARQIPVKKVYVSPGSLTSSKFQEKLKQLHSPIKVVQRGDRLPIFDHDLEVLSPDEVGDGKNDDSIVLYG
QFYQKRFLFTGDLEEAGEKKLLENYPQLQVDVLKVGHHGSKGSSSDVFLDQVHPQLALISVGKKNRYRHPHKELLDRLEE
RSISYLRTDERGAIRLIGWDHWRVETVR

Nucleotide

• Length: 2247 bp

>NTDB_id=41367 HMPREF0833_RS00915 WP_013903298.1 172039..174285(+) (comEC/celB) [Streptococcus parasanguinis ATCC 15912]
ATGCTTTCACGGTGGATTAAAGACCTTCCTTTTTCCCTTGTCCATCTCGCCTTTTTACTCCTATGGCTGTATTTTAGTGT
TTATCAACCATCTTGGCTTTCGATCAGCGGTCTAGTAGTAGTGGTAGTTTTAGCGGTTCATCACTATAAAGGGGATCGCT
CAAGTTTGCTAGGTCTTGCTTTAGCAACCCTTTGTTTTGCGGCCTTCTTTGTCTTTCATCGAATACAGGATCATCCAGTA
CAAGCAGAAAGTCAGCCCCCATCCCACTTACTCCTGATTCCAGATACTATCAAGATCAATGGGGACGCCCTGTCTTTTCG
TGCTAAAAATCAGGGAAGGACCTACCAAGTCTTCTACACTTTAAAATCAGAAAAAGAAAAACAGCAGTGGCAAAGTCAAA
CCCACTTGCTGGAGTTGACATATAAAGGTGTTATAGAGGAACCAGAAGGGCAACGAAATTTTAGAGGATTTGACTACCGG
TCTTATTTGCAAACACAGGGGATTCACTATCAAATAAAAATTGAAGCGATCCAATCCGCGCTTCCTATCCAAACTTGGAA
TGTTTTCGATTGCTTATCTCAATGGAGGCGCCAAGCCATTGTTTGGAGCAAGGAGCACTTCCCGCAGCCGATGAACCAGT
ATATGACCGGCCTTCTTTTTGGCTATTTAGATACGGATTTTGAAGAGATGGACCAGCTTTACACGAGTTTAGGAATCATC
CATTTATTCGCCTTATCTGGGATGCAGGTCGGCTTTTTCATCAATGGGATCCGGAAAGCTCTCTTACGTCTAGGAATCTT
GCAAGAGACAGTTGATATCTGGATGGTTCCAATTTCTTTGGTGTATGCTGGCTTGACAGGTTTTTCAGTTTCAGTGGTTC
GCAGTCTCTTGCAGAAGATCCTCTCTCAAAAGGGGATCCGAGGGATGGAGAATATGGCGATGACCTTGATGCTCTTAATG
CTGCTCATGCCCAAGTTTCTCCTGACAGCTGGAGGGGTCTTGAGTTGTGCTTATGCCTTTATTTTGACCTTGGTAGATAC
CAGTTCTTATTCAGGACTTAAAAAGCTACTAGTGGAAAGTTTCTGGATTAGCCTGGGGATTTTGCCCCTTTTGACCTATT
ACTTTAGTGTCTTTCAACCGTGGTCACTCCCTTTAACTTTCCTCTTTTCTTTCTTATTTGACCTTGTCCTTCTTCCAGGT
TTAACGGTGCTATTTATCTTATCGATTCTAAAGCCCCTTACAATTTTTAACAGTTTCTTTCTTCTCATAGAGGAGTGTAT
TCGTTGGATTTCAAAGCTCACGTCGCTACCTTTGGTATTTGGTCAGCCGACGGGACCAGCTCTGATTGCTCTCTTCCTTC
TTTTAGGGATCTTATATGATTTTCGAAAGCAAAAAAAACGTCGTTTCCTGTTAATAGGCATGATTCTACTCATCTTTTGT
TGGACCAAGCACCCTTTAGAAAATGAGATCACCATGGTGGATATCGGTCAAGGAGATAGTATCTTTTTACGCGATTGGAA
AGGAAGAACCATATTGATTGATGTCGGAGGACGCGTCACTTTTAAAAGTGGAGACAAGTGGCAAGAGCGCAGTCAATCTG
CCAATGCGGATCAAACCCTGATTCCCTATCTCAAGAGTCGAGGTGTTGGAAAACTCGATGCTTTGGTCTTGACTCATACA
GACCAGGACCATATGGGCGATATGTTAGAGGTTGCAAGACAAATCCCGGTTAAAAAAGTGTATGTCAGTCCAGGAAGTCT
AACCAGTTCTAAATTTCAAGAGAAATTGAAACAGCTTCATAGTCCGATTAAAGTAGTCCAAAGAGGGGATCGTCTTCCTA
TTTTTGATCATGATCTAGAAGTCTTATCCCCTGATGAAGTGGGGGATGGTAAAAATGATGATTCGATTGTCCTCTATGGG
CAGTTCTATCAGAAACGATTTTTGTTCACGGGTGATCTGGAAGAAGCTGGAGAGAAAAAACTTTTGGAAAACTATCCACA
ATTACAAGTGGATGTCTTGAAAGTAGGCCACCACGGTTCTAAAGGTTCCTCTAGTGATGTGTTTTTGGATCAGGTACATC
CTCAATTGGCCTTGATCTCTGTTGGCAAGAAAAATCGCTACCGGCATCCCCATAAAGAATTACTCGATCGATTAGAGGAA
CGATCTATTTCTTATCTTCGTACCGATGAAAGAGGAGCGATTCGCTTGATTGGATGGGACCATTGGAGGGTGGAAACGGT
CCGCTAG

Domains

Predicted by InterproScan.

• Metallo-beta-lactamase superfamily (Lactamase_B) (496-700)

• Domain of unknown function (DUF4131) (DUF4131) (30-178)

• Competence protein (Competence) (218-462)

3D structure

• AlphaFold DB: F8DFD0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEC/celB	Streptococcus mitis SK321	52.87	100	0.529
comEC/celB	Streptococcus pneumoniae TIGR4	51.936	100	0.52
comEC/celB	Streptococcus mitis NCTC 12261	52.005	100	0.52
comEC/celB	Streptococcus pneumoniae Rx1	51.669	100	0.517
comEC/celB	Streptococcus pneumoniae D39	51.669	100	0.517
comEC/celB	Streptococcus pneumoniae R6	51.669	100	0.517
comEC	Lactococcus lactis subsp. cremoris KW2	47.53	100	0.476