NTDB

Overview

Name	ciaR	Type	Regulator
Locus tag	H5023_RS18385	Genome accession	NZ_CP060005
Coordinates	3958281..3958952 (-)	Length	223 a.a.
NCBI ID	WP_003090494.1	Uniprot ID	A0A0H2ZC88
Organism	Pseudomonas aeruginosa strain WK190
Function	repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 3953281..3963952

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H5023_RS18365	-	3954618..3955637 (+)	1020	Protein_3620	chemotaxis protein	-
H5023_RS18370	-	3956007..3956543 (+)	537	Protein_3621	methyl-accepting chemotaxis protein	-
H5023_RS18375 (H5023_18290)	-	3956548..3956856 (-)	309	WP_033981920.1	hypothetical protein	-
H5023_RS18380 (H5023_18295)	carS	3956947..3958284 (-)	1338	WP_003090493.1	two-component system sensor histidine kinase CarS	-
H5023_RS18385 (H5023_18300)	ciaR	3958281..3958952 (-)	672	WP_003090494.1	two-component system response regulator CarR	Regulator
H5023_RS18390 (H5023_18305)	-	3958952..3959266 (-)	315	WP_003097704.1	PepSY domain-containing protein	-
H5023_RS18395 (H5023_18310)	-	3959266..3959574 (-)	309	WP_003090497.1	PepSY domain-containing protein	-
H5023_RS18400 (H5023_18315)	-	3959789..3960871 (+)	1083	WP_410525428.1	patatin-like phospholipase family protein	-
H5023_RS18405 (H5023_18320)	-	3960898..3961791 (+)	894	WP_003116712.1	hypothetical protein	-
H5023_RS18410 (H5023_18325)	-	3961775..3962041 (+)	267	WP_003115326.1	DUF5329 domain-containing protein	-
H5023_RS18415 (H5023_18330)	-	3962042..3963235 (-)	1194	WP_003122598.1	NnrS family protein	-
H5023_RS18420 (H5023_18335)	ppyR	3963222..3963479 (-)	258	WP_003090502.1	psl/pyoverdine operon transcriptional regulator PpyR	-

Sequence

Protein

Download Length: 223 a.a. Molecular weight: 24729.20 Da Isoelectric Point: 5.8445

                                >NTDB_id=412426 H5023_RS18385 WP_003090494.1 3958281..3958952(-) (ciaR) [Pseudomonas aeruginosa strain WK190]

MRLLLVEDHVPLADELMASLTRQGYAVDWLADGRDAAVQGASEPYDLIILDLGLPGRPGLEILQEWRGLGLATPVLILTA

RGSWAERIDGLKAGADDYLTKPFHPEELALRIQALLRRAHGLANQSQLEAAGLRLDEQRQCVCLNGADVDLTAAEFRLLR

YFMLHPGQVLSKGHLAEHLYDGETERDSNVIEVHVNHLRRKLGREVIETRRGQGYRYAGVAAG

Nucleotide

Download Length: 672 bp

                                >NTDB_id=412426 H5023_RS18385 WP_003090494.1 3958281..3958952(-) (ciaR) [Pseudomonas aeruginosa strain WK190]

ATGCGGTTGCTGCTGGTTGAGGATCACGTTCCCCTGGCCGACGAACTGATGGCCAGCCTGACCCGCCAGGGCTACGCGGT

GGACTGGCTGGCCGACGGCCGCGACGCGGCGGTGCAGGGCGCCAGCGAGCCCTACGATCTGATCATCCTCGACCTCGGCC

TGCCCGGGCGTCCCGGCCTGGAGATACTCCAGGAGTGGCGTGGGCTGGGACTCGCGACTCCGGTGCTGATCCTCACCGCG

CGCGGTTCCTGGGCCGAACGCATCGATGGGCTCAAGGCCGGTGCCGACGACTACCTGACCAAGCCGTTCCATCCGGAAGA

GCTGGCCTTGCGCATCCAGGCCCTGTTGCGCCGCGCCCATGGGCTGGCCAACCAGAGCCAGCTGGAGGCCGCCGGGCTGC

GCCTGGACGAGCAGCGCCAGTGCGTGTGCCTGAACGGCGCCGACGTCGACCTGACCGCCGCCGAATTCCGCCTGCTGCGC

TATTTCATGCTGCACCCCGGCCAGGTCCTGTCCAAGGGGCACCTGGCCGAGCATCTGTACGACGGCGAGACCGAACGCGA

TTCCAACGTCATCGAGGTCCACGTCAACCACCTGCGGCGCAAGCTCGGCCGCGAGGTGATCGAGACCCGCCGTGGTCAGG

GCTACCGCTACGCCGGGGTGGCCGCCGGATGA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(147-216)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	A0A0H2ZC88

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
ciaR	Streptococcus mutans UA159	37.727	98.655	0.372
ciaR	Streptococcus pneumoniae Rx1	37.273	98.655	0.368
ciaR	Streptococcus pneumoniae D39	37.273	98.655	0.368
ciaR	Streptococcus pneumoniae R6	37.273	98.655	0.368
ciaR	Streptococcus pneumoniae TIGR4	37.273	98.655	0.368
micA	Streptococcus pneumoniae Cp1015	35.683	100	0.363
vicR	Streptococcus mutans UA159	35.526	100	0.363

Detailed information NTG0412426