Detailed information    

insolico Bioinformatically predicted

Overview

Name   pknB   Type   Regulator
Locus tag   GPZ88_RS06675 Genome accession   NZ_CP046919
Coordinates   1292597..1294486 (+) Length   629 a.a.
NCBI ID   WP_166043779.1    Uniprot ID   A0A6G8I0U6
Organism   Streptococcus ruminicola strain CNU_G2     
Function   modulate the activity of ComDE; modulate the activity of VicKR (predicted from homology)   
Competence regulation

Genomic Context

Location: 1287597..1299486
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  GPZ88_RS06660 (GPZ88_06640) fmt 1289575..1290510 (+) 936 WP_074561288.1 methionyl-tRNA formyltransferase -
  GPZ88_RS06665 (GPZ88_06645) rsmB 1290500..1291822 (+) 1323 WP_157628767.1 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB -
  GPZ88_RS06670 (GPZ88_06650) - 1291860..1292597 (+) 738 WP_039695890.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  GPZ88_RS06675 (GPZ88_06655) pknB 1292597..1294486 (+) 1890 WP_166043779.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  GPZ88_RS06680 (GPZ88_06660) liaF 1294584..1295279 (+) 696 WP_039695888.1 cell wall-active antibiotics response protein LiaF -
  GPZ88_RS06685 (GPZ88_06665) - 1295276..1296301 (+) 1026 WP_074799172.1 sensor histidine kinase -
  GPZ88_RS06690 (GPZ88_06670) - 1296285..1296929 (+) 645 WP_039695886.1 response regulator transcription factor -
  GPZ88_RS06695 (GPZ88_06675) - 1297054..1298454 (+) 1401 WP_081348706.1 Cof-type HAD-IIB family hydrolase -
  GPZ88_RS06700 (GPZ88_06680) - 1298454..1298810 (+) 357 WP_020916316.1 S1 RNA-binding domain-containing protein -

Sequence

Protein


Download         Length: 629 a.a.        Molecular weight: 68265.21 Da        Isoelectric Point: 6.7919

>NTDB_id=409443 GPZ88_RS06675 WP_166043779.1 1292597..1294486(+) (pknB) [Streptococcus ruminicola strain CNU_G2]
MIQIGKLFAGRYRILKSIGRGGMADVYLAKDLILDNEEVAIKVLRTNYQTDQIAVARFQREARAMAELNHPNIVSIRDIG
EEDGQQFLVMEYVDGSDLKKYIQDHAPLSNNEVVRIMEEVLSAMTLAHQQGIVHRDLKPQNILLTKDGTVKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATVQSDIYAMGIMLFEMLTGHIPYDGDSAVTIALQHFQKPLPSIIDENKNVP
QALENVVIKATAKRLSDRYASTFEMSRDLMTALSYNRSRERKLVFEDTENTKTLPKVTTSTPVPSTTEQLLKKQKAAKVN
REAADNKIAKAKTKKKKSHRMFGTLVKIFFAVVVVAIAIFTYLTLSTPASVNVPDVAGTSLADAKTSLTSAGLKVGDIHK
VASDTVQKGHVIKTDPTAGSSKKEGAKVDIYVSKGTSGFKMKDYTGQNYQEVIKELKDKHGISSDKIDVEWITGTNYDGG
TIISQTPEKGTRVASENKITFKVAAIVMPNLIGYTYQDAIAELTALGLSSSHITVFQADATSSTGYSQVKTPSASAVVVA
QDPYFGAAIEGNVKLYFSSGSEVQPSEVAPSQSVPESSETSETSESSSSSSSSSSTEESSQTDSSSVEQ

Nucleotide


Download         Length: 1890 bp        

>NTDB_id=409443 GPZ88_RS06675 WP_166043779.1 1292597..1294486(+) (pknB) [Streptococcus ruminicola strain CNU_G2]
ATGATTCAGATTGGCAAATTATTTGCTGGTCGTTATCGGATCCTCAAATCTATCGGACGGGGTGGAATGGCAGATGTTTA
TCTTGCCAAAGATCTAATTCTTGATAATGAAGAAGTGGCTATCAAAGTCCTTCGAACTAATTATCAAACAGATCAAATTG
CCGTTGCTCGTTTCCAACGTGAAGCGCGTGCCATGGCAGAGCTAAACCATCCAAATATCGTTTCGATTCGTGATATTGGA
GAAGAAGACGGACAGCAATTCTTAGTAATGGAATATGTTGATGGTTCGGACTTGAAAAAATACATTCAAGACCATGCCCC
GCTTTCTAATAATGAAGTTGTTAGAATCATGGAAGAAGTCTTGTCTGCAATGACTTTGGCTCATCAACAAGGAATTGTTC
ACCGTGATTTGAAACCACAAAATATCTTGTTAACCAAAGACGGAACGGTTAAAGTTACCGACTTTGGTATCGCTGTAGCC
TTTGCAGAAACAAGTTTAACACAGACAAACTCAATGCTTGGTAGTGTACACTATTTATCACCTGAACAAGCGCGTGGATC
AAAAGCCACTGTTCAAAGTGATATCTACGCTATGGGGATTATGTTGTTTGAAATGTTGACTGGTCACATCCCATATGATG
GTGATTCAGCTGTTACAATTGCTCTTCAACATTTCCAAAAACCACTTCCATCAATCATTGATGAAAATAAAAATGTTCCA
CAAGCTTTGGAAAATGTTGTCATTAAAGCAACTGCAAAACGTTTGAGTGATCGCTACGCCTCAACTTTTGAGATGAGCCG
TGATTTAATGACTGCTCTTTCATATAACCGCAGTCGTGAACGCAAACTTGTCTTTGAAGATACAGAAAATACGAAGACAC
TTCCAAAAGTAACAACTTCAACACCTGTTCCCTCAACTACAGAACAATTGTTGAAAAAACAAAAAGCAGCTAAAGTTAAT
CGTGAAGCTGCGGATAATAAAATTGCAAAAGCGAAAACGAAGAAGAAAAAATCACATCGTATGTTTGGTACTTTAGTGAA
AATTTTCTTTGCGGTCGTAGTAGTTGCAATTGCTATCTTTACTTACTTGACGCTAAGCACACCAGCTTCAGTCAACGTTC
CAGATGTAGCAGGAACAAGTTTAGCAGATGCTAAGACAAGTTTAACTTCAGCTGGACTTAAAGTTGGTGATATTCATAAA
GTAGCTAGTGATACTGTGCAAAAAGGTCATGTTATTAAGACTGACCCAACAGCAGGTTCATCTAAAAAAGAAGGTGCCAA
AGTTGACATTTATGTGTCAAAAGGAACATCAGGCTTTAAGATGAAAGATTATACTGGTCAAAACTATCAAGAAGTTATCA
AAGAACTCAAAGATAAGCACGGTATTTCAAGTGATAAGATTGATGTTGAATGGATAACAGGTACTAACTATGACGGTGGT
ACTATCATTAGTCAAACACCTGAAAAAGGTACAAGAGTAGCTAGTGAAAATAAGATTACTTTCAAGGTTGCAGCAATTGT
TATGCCAAACCTTATTGGGTATACTTACCAAGATGCAATTGCTGAATTGACTGCACTTGGCTTATCAAGCTCACATATTA
CAGTATTCCAAGCAGATGCTACTTCATCAACTGGATACTCTCAAGTCAAAACACCATCTGCCTCTGCAGTTGTTGTGGCA
CAAGATCCTTACTTTGGCGCAGCTATTGAAGGAAATGTGAAACTTTACTTCTCATCTGGAAGTGAAGTTCAACCTTCTGA
AGTAGCACCATCTCAATCTGTTCCTGAGTCATCTGAGACAAGTGAAACTAGTGAGTCAAGTTCTTCAAGTAGCAGCAGTA
GCAGCACTGAGGAAAGTTCACAAACCGACTCATCATCAGTTGAACAATAA

Domains

Predicted by InterproScan.

PASTA domain (PASTA)

(507-578)

PASTA domain (PASTA)

(440-503)

PASTA domain (PASTA)

(371-434)

Protein kinase domain (Pkinase)

(12-247)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A6G8I0U6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pknB Streptococcus mutans UA159

65.849

90.779

0.598
  stkP/pknB Streptococcus salivarius strain HSISS4

62.669

94.118

0.59
  stkP Streptococcus pneumoniae TIGR4

58.757

84.42

0.496
  stkP Streptococcus pneumoniae D39

58.569

84.42

0.494
  stkP Streptococcus pneumoniae R6

58.569

84.42

0.494
  stkP Streptococcus pneumoniae Rx1

58.38

84.42

0.493

Multiple sequence alignment