Detailed information    

insolico Bioinformatically predicted

Overview

Name   pknB   Type   Regulator
Locus tag   GO596_RS00720 Genome accession   NZ_CP046628
Coordinates   140905..142779 (-) Length   624 a.a.
NCBI ID   WP_157339045.1    Uniprot ID   -
Organism   Streptococcus equinus strain CNU 77-23     
Function   modulate the activity of ComDE; modulate the activity of VicKR (predicted from homology)   
Competence regulation

Genomic Context

Location: 135905..147779
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  GO596_RS00695 (GO596_00695) - 136536..136892 (-) 357 WP_027968108.1 S1 RNA-binding domain-containing protein -
  GO596_RS00700 (GO596_00700) - 136892..138292 (-) 1401 WP_029876003.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  GO596_RS00705 (GO596_00705) - 138416..139060 (-) 645 WP_024344653.1 response regulator transcription factor -
  GO596_RS00710 (GO596_00710) - 139044..140069 (-) 1026 WP_157339044.1 sensor histidine kinase -
  GO596_RS00715 (GO596_00715) liaF 140066..140761 (-) 696 WP_027968110.1 cell wall-active antibiotics response protein LiaF -
  GO596_RS00720 (GO596_00720) pknB 140905..142779 (-) 1875 WP_157339045.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  GO596_RS00725 (GO596_00725) - 142779..143516 (-) 738 WP_157339046.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  GO596_RS00730 (GO596_00730) rsmB 143554..144876 (-) 1323 WP_157339047.1 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB -
  GO596_RS00735 (GO596_00735) fmt 144866..145801 (-) 936 WP_039691948.1 methionyl-tRNA formyltransferase -

Sequence

Protein


Download         Length: 624 a.a.        Molecular weight: 68064.86 Da        Isoelectric Point: 5.4470

>NTDB_id=406211 GO596_RS00720 WP_157339045.1 140905..142779(-) (pknB) [Streptococcus equinus strain CNU 77-23]
MIQIGKLFAGRYRILKSIGRGGMADVYLAKDLILDNEEVAIKVLRTNYQTDQIAVARFQREARAMAELNHPNIVSIRDIG
EEDGQQFLVMEYVDGSDLKKYIQDHAPLSNNEVVRIMEEVLSAMTLAHQQGIVHRDLKPQNILLTKDGTVKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATVQSDIYAMGIMLFEMLTGHIPYDGDSAVTIALQHFQKPLPSIIDENKNVP
QALENVVIKATAKRLSDRYASTFEMSRDLMTALSYNRSRERKLVFEDTENTKTLPKVTTSTPVPSTTEQLLKKQKAAKEN
KEVANQKAPKAKAKKKKSHRMFGTLMKIFFAVVVVAIAIFTYLTLSTPASVNVPDVSGAALSDAKTSLLSSGLKIGDIHK
VSSDTVAEGYVVKTDPTAGSSKKEGAKVDIYVSKGSSEFKMKDYTGQNYQDVIKELEKKHGISSKMIDIEWVTDTSYDSG
TIISQTPEEGTKVGSKDKITFEVAAITMPSLIGYTYQEAIAELNSMGVSSSHITIYMADATSSTGYSRVSSVSSSAVVVA
QDPYYGGAVEGEVNLYFSSETAAQPSEEPSQSVPESSETSETSESSSSSSSTEESSEASTEMQQ

Nucleotide


Download         Length: 1875 bp        

>NTDB_id=406211 GO596_RS00720 WP_157339045.1 140905..142779(-) (pknB) [Streptococcus equinus strain CNU 77-23]
ATGATTCAGATTGGCAAATTATTTGCTGGTCGTTATCGTATCCTTAAATCAATCGGACGGGGTGGAATGGCAGATGTTTA
TCTTGCCAAAGATCTGATTCTTGATAATGAAGAAGTAGCTATCAAAGTTCTTCGGACTAATTATCAAACAGATCAAATTG
CCGTAGCTCGTTTCCAACGTGAAGCGCGCGCCATGGCAGAGTTGAACCATCCCAATATTGTTTCGATTCGAGATATTGGA
GAAGAGGACGGACAGCAATTCTTAGTAATGGAATATGTTGATGGTTCTGACTTGAAAAAATACATTCAAGATCATGCGCC
TCTATCTAATAACGAAGTTGTTAGAATTATGGAAGAAGTCTTGTCAGCAATGACTCTTGCCCATCAACAAGGAATTGTTC
ACCGTGACTTAAAACCACAAAATATTTTGTTGACTAAAGACGGAACTGTAAAAGTTACTGACTTTGGTATTGCTGTAGCT
TTTGCAGAAACAAGTTTAACACAGACAAACTCAATGCTTGGTAGTGTGCATTATTTGTCACCTGAACAAGCGCGCGGTTC
AAAAGCCACTGTTCAAAGTGATATCTATGCTATGGGGATTATGTTGTTTGAAATGTTAACAGGTCACATTCCTTATGATG
GGGATTCAGCTGTTACCATTGCTTTGCAACATTTCCAAAAACCACTTCCATCAATCATTGATGAAAACAAAAATGTTCCT
CAAGCTTTGGAAAATGTAGTTATCAAAGCAACAGCAAAACGTTTAAGCGACCGTTATGCATCAACATTTGAAATGAGTCG
TGATTTGATGACGGCACTTTCATACAACCGTAGTCGAGAACGTAAACTTGTTTTTGAGGATACAGAAAATACTAAGACAC
TTCCAAAAGTGACTACTTCAACACCTGTTCCATCAACGACAGAACAATTGTTGAAAAAACAAAAAGCTGCAAAAGAAAAT
AAAGAAGTAGCTAATCAAAAAGCACCTAAAGCGAAGGCTAAAAAGAAAAAATCTCATCGTATGTTTGGTACTTTGATGAA
AATCTTCTTTGCAGTCGTTGTTGTTGCGATTGCTATCTTTACTTACTTAACTTTAAGTACACCAGCTTCAGTTAATGTTC
CAGATGTATCTGGTGCGGCTTTATCTGATGCTAAGACAAGCTTGTTATCATCTGGTTTGAAGATTGGTGATATCCACAAA
GTTTCTAGTGATACAGTTGCTGAAGGTTACGTTGTTAAAACAGATCCGACTGCTGGTTCATCTAAGAAAGAAGGAGCTAA
AGTTGATATTTATGTATCAAAAGGAAGTTCTGAATTTAAGATGAAAGATTACACTGGTCAAAATTATCAAGATGTCATCA
AGGAGCTTGAAAAGAAACATGGTATTTCAAGTAAAATGATTGATATCGAGTGGGTAACTGATACTTCATATGATAGTGGT
ACTATTATCAGCCAAACTCCAGAAGAAGGAACAAAAGTTGGTAGTAAAGATAAAATCACTTTTGAGGTAGCAGCAATCAC
AATGCCTAGTCTTATTGGTTATACTTACCAAGAAGCGATTGCTGAGTTAAATTCTATGGGTGTATCAAGCTCACATATTA
CAATTTATATGGCAGATGCAACTTCATCAACAGGATATTCTCGAGTAAGCTCAGTATCAAGTTCTGCGGTTGTCGTTGCT
CAGGATCCTTATTATGGTGGGGCAGTTGAAGGAGAGGTTAACCTTTACTTCTCTTCAGAAACGGCTGCGCAACCATCTGA
AGAACCGTCACAATCAGTTCCAGAATCATCTGAAACAAGTGAGACAAGTGAATCAAGTTCATCAAGTAGTAGTACTGAAG
AAAGTTCAGAAGCATCTACTGAAATGCAACAATAA

Domains

Predicted by InterproScan.

Protein kinase domain (Pkinase)

(12-247)

PASTA domain (PASTA)

(506-578)

PASTA domain (PASTA)

(440-503)

PASTA domain (PASTA)

(371-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pknB Streptococcus mutans UA159

66.9

91.506

0.612
  stkP/pknB Streptococcus salivarius strain HSISS4

64.177

94.391

0.606
  stkP Streptococcus pneumoniae TIGR4

57.827

87.019

0.503
  stkP Streptococcus pneumoniae D39

57.643

87.019

0.502
  stkP Streptococcus pneumoniae R6

57.643

87.019

0.502
  stkP Streptococcus pneumoniae Rx1

57.459

87.019

0.5

Multiple sequence alignment