Detailed information NTG0403676

Bioinformatically predicted

Overview

• Name: comEC/celB
• Type: Machinery gene
• Locus tag: GL187_RS04430
• Genome accession: NZ_CP046379
• Coordinates: 871530..873770 (+)
• Length: 746 a.a.
• NCBI ID: WP_050259602.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain 563
• Function: ssDNA transport into the cell (predicted from homology) DNA binding and uptake

Genomic Context

Location: 866530..878770

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GL187_RS04385 (GL187_04470)	-	866679..867647 (+)	969	WP_000658183.1	PhoH family protein	-
GL187_RS04395 (GL187_04480)	-	867840..868340 (+)	501	WP_000566988.1	GNAT family N-acetyltransferase	-
GL187_RS04400 (GL187_04485)	-	868343..868669 (+)	327	Protein_880	TfoX/Sxy family protein	-
GL187_RS11165	ald	868970..870081 (-)	1112	Protein_881	alanine dehydrogenase	-
GL187_RS04420 (GL187_04505)	-	870259..870828 (+)	570	WP_000443770.1	GNAT family N-acetyltransferase	-
GL187_RS04425 (GL187_04510)	comEA/celA/cilE	870896..871546 (+)	651	WP_050259603.1	helix-hairpin-helix domain-containing protein	Machinery gene
GL187_RS04430 (GL187_04515)	comEC/celB	871530..873770 (+)	2241	WP_050259602.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
GL187_RS04435 (GL187_04520)	-	873949..874137 (+)	189	WP_001809102.1	hypothetical protein	-
GL187_RS04440 (GL187_04525)	-	874169..874756 (+)	588	WP_050259601.1	ATP-binding cassette domain-containing protein	-
GL187_RS04445 (GL187_04530)	-	874760..875944 (+)	1185	WP_083979551.1	hypothetical protein	-
GL187_RS04450 (GL187_04535)	infC	876255..876785 (+)	531	WP_000848180.1	translation initiation factor IF-3	-
GL187_RS04455 (GL187_04540)	rpmI	876818..877018 (+)	201	WP_001125943.1	50S ribosomal protein L35	-
GL187_RS04460 (GL187_04545)	rplT	877070..877429 (+)	360	WP_000124836.1	50S ribosomal protein L20	-
GL187_RS04465 (GL187_04550)	-	877487..877867 (+)	381	WP_000157154.1	VOC family protein	-

Sequence

Protein

• Length: 746 a.a.
• Molecular weight: 84582.14 Da
• Isoelectric Point: 9.4492

>NTDB_id=403676 GL187_RS04430 WP_050259602.1 871530..873770(+) (comEC/celB) [Streptococcus pneumoniae strain 563]
MLQWIKNIPIPLIYLSFLLLWFYYAIFSASYLALLGFVFLLVCLFFQFPWKSAGKVLIICGIFGFWFVFQNWQQSQASQN
LADSVERVRILPDTIKVNGDSLSFRGKSNGRAFQVYYKLQSEEEKEAFQALTDLHEIGLEGKLSEPEGQRNFGGFNYQAY
LKTQGIYQTLNIKTIQSLQKIGSWDIGENLSSLRRKAVVWIKTHFPDPMRNYMTGLLLGHLDTDFEEMNELYSSLGIIHL
FALSGMQVGFFMNGFKKLLLQLGLTQEKLKWLTYPFSLIYAGLTGFSASVIRSLLQKLLAQHGVKGLDNFALTVLVLFIV
MPNFFLTAGGVLSCAYAFILTMTSKEGEGLKAVASESLVISLGILPILSFYFAEFQPWSILLTFVFSFLFDLTFLPLLSI
LFVLSFLYPVIQLNFIFEWLEGIIRLVSQVTSRPLVFGQPNAWFLILLLISLALVYDLRKNIKKLTVLCLLITGLFLLTK
HPLENEITMLDVGQGESIFLRDVTGKTILIDVGGKAESYKKIEKWQEKMTTSNAQRTLIPYLKSRGVVKIDQLILTNTDK
EHVGDLSEMTKAFHVGEILVSKDSLKQKEFVAELQATQTKVRSMIVGENLPIFGSQLEVLSPRKMGDGGHDDTLVLYGKF
LDKQFLFTGNLEEKGEKDLLKHYPDLKVNVLKASQHGNKKSSSPAFLEKLKPELTLISVGKSNRMKLPHQETLTRLEGIN
SKVYRTDQQGAIRFKGLDSWKIESVR

Nucleotide

• Length: 2241 bp

>NTDB_id=403676 GL187_RS04430 WP_050259602.1 871530..873770(+) (comEC/celB) [Streptococcus pneumoniae strain 563]
ATGTTACAGTGGATTAAGAACATCCCCATTCCCCTAATTTACCTGAGTTTTTTGTTACTTTGGTTTTATTACGCTATTTT
CTCAGCATCCTATCTTGCTTTGTTGGGCTTTGTTTTTCTGCTAGTCTGTCTCTTTTTCCAATTTCCTTGGAAATCTGCTG
GTAAAGTTCTAATAATTTGCGGAATCTTTGGATTTTGGTTTGTTTTTCAAAATTGGCAACAGAGTCAAGCGAGTCAAAAT
CTGGCGGATTCTGTTGAAAGGGTACGGATTTTGCCTGATACTATTAAGGTTAATGGTGATAGTCTATCCTTTCGTGGCAA
GTCTAACGGTCGTGCTTTCCAAGTCTATTATAAACTCCAGTCCGAGGAGGAGAAAGAAGCCTTTCAAGCTTTAACCGACC
TGCATGAGATAGGACTAGAAGGGAAGCTTTCGGAGCCAGAAGGGCAGAGAAATTTTGGTGGCTTTAATTACCAAGCCTAT
CTGAAGACTCAGGGAATTTACCAGACTCTCAATATCAAAACAATCCAGTCACTTCAAAAGATTGGCAGTTGGGATATAGG
AGAAAACTTGTCCAGTTTACGTCGAAAGGCTGTGGTTTGGATTAAGACGCACTTTCCAGACCCTATGCGCAATTACATGA
CAGGACTCTTGCTGGGACATCTGGACACCGACTTTGAGGAGATGAATGAGCTTTATTCCAGTCTAGGAATTATCCACCTC
TTTGCCCTATCTGGCATGCAGGTAGGTTTTTTCATGAATGGATTTAAGAAACTTCTCTTGCAATTGGGCTTGACCCAAGA
AAAGTTGAAATGGCTGACTTATCCCTTTTCCCTTATCTATGCGGGACTAACTGGATTTTCAGCATCGGTTATTCGCAGTC
TCTTGCAAAAGCTACTGGCTCAACATGGGGTTAAGGGCTTGGATAATTTTGCCTTGACGGTGCTTGTCCTCTTTATTGTC
ATGCCAAACTTTTTCTTGACAGCAGGAGGAGTCTTGTCCTGCGCTTATGCTTTTATCCTGACCATGACCAGCAAAGAAGG
GGAGGGGCTCAAGGCTGTTGCTAGTGAAAGTCTAGTCATCTCCTTGGGCATATTGCCCATTCTATCCTTCTATTTTGCGG
AATTTCAACCTTGGTCTATCCTTTTGACCTTTGTCTTTTCCTTTCTATTTGACTTGACCTTCTTACCGCTCTTGTCTATT
TTATTTGTCCTTTCCTTTCTCTATCCAGTCATTCAGCTGAACTTTATCTTTGAATGGTTGGAGGGCATTATTCGCTTGGT
GTCACAGGTGACAAGTAGACCTCTGGTCTTTGGACAACCCAATGCATGGTTTTTAATCCTATTGTTAATTTCCTTGGCTT
TGGTCTATGATTTGAGAAAAAACATTAAAAAGCTAACGGTATTGTGCTTATTGATTACAGGGCTCTTTCTCCTGACCAAG
CATCCACTGGAAAATGAAATCACCATGCTGGATGTGGGGCAAGGAGAAAGTATTTTCCTACGGGATGTAACTGGGAAAAC
CATTCTCATAGATGTAGGTGGTAAGGCAGAATCTTATAAGAAAATCGAAAAATGGCAAGAAAAGATGACGACCAGCAATG
CCCAGCGAACCTTGATTCCCTATCTCAAAAGTCGAGGAGTAGTTAAGATTGACCAGCTAATTTTGACTAACACGGACAAG
GAGCATGTTGGAGATTTGTCAGAGATGACCAAGGCTTTCCATGTAGGGGAGATTCTAGTATCAAAAGACAGTCTGAAACA
GAAGGAATTTGTGGCAGAACTACAGGCGACTCAAACAAAGGTGCGTAGTATGATAGTAGGGGAGAACTTGCCCATTTTTG
GAAGTCAGTTAGAAGTTCTATCTCCAAGGAAAATGGGAGATGGAGGACACGATGATACCCTAGTTCTGTATGGGAAATTC
TTGGATAAGCAATTTCTCTTCACGGGAAATTTGGAGGAGAAAGGAGAGAAGGACTTGCTGAAGCACTATCCAGACTTGAA
AGTAAATGTTTTGAAAGCTAGCCAACATGGCAATAAAAAATCATCAAGTCCAGCCTTTCTAGAAAAACTCAAACCAGAGC
TTACTCTTATCTCAGTTGGAAAGAGCAATCGAATGAAACTCCCCCATCAGGAAACATTGACACGACTGGAAGGTATCAAT
AGCAAAGTTTATCGAACTGACCAGCAAGGAGCTATACGTTTTAAGGGGTTGGATAGTTGGAAAATCGAAAGTGTTCGATA
G

Domains

Predicted by InterproScan.

• Domain of unknown function (DUF4131) (DUF4131) (30-176)

• Metallo-beta-lactamase superfamily (Lactamase_B) (492-693)

• Competence protein (Competence) (216-458)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEC/celB	Streptococcus pneumoniae Rx1	97.721	100	0.977
comEC/celB	Streptococcus pneumoniae D39	97.721	100	0.977
comEC/celB	Streptococcus pneumoniae R6	97.721	100	0.977
comEC/celB	Streptococcus pneumoniae TIGR4	97.721	100	0.977
comEC/celB	Streptococcus mitis SK321	91.421	100	0.914
comEC/celB	Streptococcus mitis NCTC 12261	91.275	99.866	0.912
comEC	Lactococcus lactis subsp. cremoris KW2	43.817	99.732	0.437