Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA/nlmT   Type   Regulator
Locus tag   GL187_RS02485 Genome accession   NZ_CP046379
Coordinates   484718..486394 (-) Length   558 a.a.
NCBI ID   WP_215729172.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain 563     
Function   transport of ComC (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 464102..489481 484718..486394 within 0


Gene organization within MGE regions


Location: 464102..489481
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  GL187_RS02380 (GL187_02450) - 464102..465382 (+) 1281 WP_001220759.1 restriction endonuclease subunit S -
  GL187_RS02385 (GL187_02455) psrA 465439..466236 (+) 798 WP_000651177.1 tyrosine-type DNA invertase PsrA -
  GL187_RS02390 (GL187_02460) - 466277..466854 (+) 578 Protein_477 restriction endonuclease subunit S -
  GL187_RS02400 (GL187_02470) - 466802..468366 (-) 1565 Protein_478 restriction endonuclease subunit S -
  GL187_RS02405 (GL187_02475) - 468366..469829 (-) 1464 WP_000029036.1 HsdM family class I SAM-dependent methyltransferase -
  GL187_RS02410 (GL187_02480) hsdR 469842..472175 (-) 2334 WP_024477921.1 EcoAI/FtnUII family type I restriction enzme subunit R -
  GL187_RS02415 (GL187_02490) - 472783..473292 (+) 510 WP_001088689.1 DUF2812 domain-containing protein -
  GL187_RS02420 (GL187_02495) hrcA 473456..474490 (+) 1035 WP_000255779.1 heat-inducible transcriptional repressor HrcA -
  GL187_RS02425 (GL187_02500) grpE 474517..475041 (+) 525 WP_000046031.1 nucleotide exchange factor GrpE -
  GL187_RS02430 (GL187_02505) dnaK 475521..477344 (+) 1824 WP_000034662.1 molecular chaperone DnaK -
  GL187_RS02435 (GL187_02510) - 477346..477702 (+) 357 WP_000114422.1 hypothetical protein -
  GL187_RS02440 (GL187_02515) dnaJ 478104..479240 (+) 1137 WP_001066295.1 molecular chaperone DnaJ -
  GL187_RS02445 (GL187_02520) - 479574..479768 (-) 195 WP_001808905.1 hypothetical protein -
  GL187_RS02450 (GL187_02525) - 479930..480217 (-) 288 WP_000777753.1 hypothetical protein -
  GL187_RS02455 (GL187_02530) - 480227..480637 (-) 411 WP_001278301.1 HIT family protein -
  GL187_RS02460 (GL187_02535) pptA 480705..481436 (+) 732 WP_000889921.1 ABC transporter ATP-binding protein Regulator
  GL187_RS02465 (GL187_02540) - 481433..482482 (+) 1050 WP_000653771.1 ABC transporter permease -
  GL187_RS02470 (GL187_02545) - 482650..482979 (-) 330 WP_000132572.1 hypothetical protein -
  GL187_RS02475 (GL187_02550) blpC 483161..483289 (-) 129 WP_000358815.1 quorum-sensing system pheromone BlpC -
  GL187_RS02480 (GL187_02555) - 483346..484707 (-) 1362 WP_001069060.1 bacteriocin secretion accessory protein -
  GL187_RS02485 (GL187_02560) comA/nlmT 484718..486394 (-) 1677 WP_215729172.1 peptide cleavage/export ABC transporter Regulator
  GL187_RS11535 comA/nlmT 486288..486875 (-) 588 WP_000205166.1 cysteine peptidase family C39 domain-containing protein Regulator
  GL187_RS02495 (GL187_02565) blpI 487157..487354 (+) 198 WP_001093259.1 bacteriocin-like peptide BlpI -
  GL187_RS02500 (GL187_02570) blpJ 487821..488090 (+) 270 WP_001093248.1 bacteriocin-like peptide BlpJ -
  GL187_RS02505 (GL187_02575) blpK 488159..488407 (+) 249 WP_000379965.1 bacteriocin-like peptide BlpK -
  GL187_RS02510 (GL187_02580) cipB 488651..488800 (+) 150 WP_001809846.1 bacteriocin-like peptide BlpO Regulator
  GL187_RS02515 (GL187_02585) - 488904..489023 (+) 120 WP_000346296.1 PncF family bacteriocin immunity protein -

Sequence

Protein


Download         Length: 558 a.a.        Molecular weight: 62977.29 Da        Isoelectric Point: 6.7844

>NTDB_id=403667 GL187_RS02485 WP_215729172.1 484718..486394(-) (comA/nlmT) [Streptococcus pneumoniae strain 563]
MIFKQKSLIAYIVLSSLLVTIINIGGSYYLQGILDEYIPNQMKSTLGIISVGLVITYILQQVMSFSRDYLLTVLSQRLSI
DVILSYIRHIFELPMSFFATRRTGEIISRFTDANSIIDALASTILSLFLDVSILILVGGVLLVQNPNLFLLSLISIPIYM
FIIFSFMKPFEKMNHDVMQSNSMVSSAIIEDINGIETIKSLTSEENRYQNIDSEFVDYLEKSFKLSKYSILQTSLKQGTK
LVLNILILWFGAQLVMSSKISIGQLITFNTLFSYFTTPMENIINLQTKLQSAKVANNRLNEVYLVESEFQVQENPVHSHF
LMGDIEFDDLSYKYGFGRDTLTDINLTIKQGDKVSLVGVSGSGKTTLAKMIVNFFEPYKGHISINHQDIKNIDKKVLRRH
INYLPQQAYIFNGSILENLTLGGNHMISQEDILRACELAEIRQDIERMPMGYQTQLSDGAGLSGGQKQRIALARALLTKA
PVLILDEATSGLDVLTEKKVIDNLMSLTDKTILFVAHRLSIAERTNRVIVLDQGKIIEVGSHQELMQAQGFYHHLFNK

Nucleotide


Download         Length: 1677 bp        

>NTDB_id=403667 GL187_RS02485 WP_215729172.1 484718..486394(-) (comA/nlmT) [Streptococcus pneumoniae strain 563]
CTGATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGCTTATTGGTCACTATTATCAATATAGGTGGTTC
TTACTATCTCCAAGGAATCTTGGATGAATACATTCCAAATCAGATGAAATCAACTTTAGGAATCATCTCAGTTGGTCTGG
TTATCACCTATATCCTCCAACAAGTCATGAGCTTCTCCAGAGATTATCTCCTAACCGTTCTGAGTCAGAGATTAAGTATT
GATGTGATTTTATCCTATATTCGCCATATTTTTGAACTTCCCATGTCTTTCTTTGCGACACGTCGTACAGGAGAAATCAT
TTCACGATTCACAGATGCTAACTCTATTATAGATGCCTTGGCTTCTACCATTCTTTCTCTTTTTCTGGATGTTTCTATTC
TGATTCTTGTAGGAGGCGTCTTACTGGTACAAAACCCTAATCTCTTCCTTCTTTCTCTTATTTCCATTCCTATATACATG
TTCATCATCTTTTCTTTTATGAAACCTTTCGAAAAAATGAACCATGATGTCATGCAAAGTAATTCTATGGTTAGCTCTGC
CATTATCGAAGATATCAACGGGATTGAAACTATAAAGTCGCTCACGAGTGAAGAAAATCGCTATCAAAATATAGACAGCG
AATTTGTAGATTATTTGGAAAAATCCTTTAAGCTCAGTAAATATTCTATTTTACAAACGAGTTTAAAGCAGGGAACAAAA
TTAGTTCTGAATATCCTTATCCTATGGTTTGGCGCTCAATTAGTCATGTCGAGTAAAATTTCTATCGGTCAGCTGATTAC
CTTTAACACACTTTTTTCTTACTTTACAACTCCTATGGAAAATATTATCAACCTCCAAACCAAACTCCAATCTGCGAAGG
TCGCTAATAACCGTTTGAACGAAGTCTATCTAGTCGAATCTGAATTTCAAGTTCAAGAAAACCCTGTCCATTCACATTTT
TTGATGGGCGATATTGAATTTGATGACCTTTCTTATAAGTATGGTTTTGGACGAGATACCTTAACAGATATTAATCTCAC
GATTAAACAAGGAGATAAGGTTAGCCTAGTTGGAGTTAGTGGTTCTGGTAAAACAACTTTAGCCAAAATGATTGTCAATT
TCTTTGAACCCTACAAAGGACATATTTCTATCAATCATCAGGATATTAAAAACATTGATAAAAAAGTCTTGCGCCGTCAT
ATTAATTACCTACCACAACAAGCCTATATCTTTAATGGCTCTATCTTGGAAAACTTAACTTTGGGCGGTAATCATATGAT
TAGCCAAGAAGATATTCTAAGAGCTTGTGAATTAGCTGAAATTCGTCAAGACATTGAAAGAATGCCTATGGGCTATCAAA
CTCAGCTCTCTGATGGAGCTGGTCTATCAGGAGGACAAAAGCAACGAATAGCCCTCGCTCGTGCTCTTTTAACTAAAGCT
CCTGTTTTAATACTAGACGAAGCTACTAGCGGTCTTGATGTCTTGACTGAGAAAAAGGTTATAGATAATCTTATGTCTCT
AACTGATAAAACCATTCTCTTTGTAGCCCATCGTCTCAGTATAGCCGAACGAACCAACCGTGTCATTGTTCTTGACCAGG
GGAAAATCATTGAAGTTGGTAGTCACCAAGAGTTAATGCAGGCGCAAGGTTTCTACCATCATCTATTCAATAAATAA

Domains

Predicted by InterproScan.

ABC transporter (ABC_tran)

(341-490)

ABC transporter transmembrane region (ABC_membrane)

(10-279)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA/nlmT Streptococcus mutans UA159

72.89

99.821

0.728
  comA Streptococcus mitis NCTC 12261

67.563

100

0.676
  comA Streptococcus pneumoniae D39

67.204

100

0.672
  comA Streptococcus pneumoniae R6

67.204

100

0.672
  comA Streptococcus pneumoniae Rx1

67.204

100

0.672
  comA Streptococcus mitis SK321

67.025

100

0.67
  comA Streptococcus gordonii str. Challis substr. CH1

66.905

100

0.67
  comA Streptococcus pneumoniae TIGR4

66.846

100

0.668

Multiple sequence alignment