Detailed information    

insolico Bioinformatically predicted

Overview

Name   comC/comC2   Type   Regulator
Locus tag   GL188_RS10785 Genome accession   NZ_CP046359
Coordinates   2113955..2114080 (-) Length   41 a.a.
NCBI ID   WP_000799694.1    Uniprot ID   Q9WW44
Organism   Streptococcus pneumoniae strain 573     
Function   binding to ComD; induce autophosphorylation of ComD (predicted from homology)   
Competence regulation

Genomic Context

Location: 2108955..2119080
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  GL188_RS11365 - 2109293..2110896 (-) 1604 Protein_2103 YhgE/Pip family protein -
  GL188_RS10760 (GL188_10935) - 2111075..2111617 (+) 543 WP_001158269.1 TetR/AcrR family transcriptional regulator -
  GL188_RS10775 (GL188_10950) comE 2111860..2112612 (-) 753 WP_000866065.1 competence system response regulator transcription factor ComE Regulator
  GL188_RS10780 (GL188_10955) comD/comD2 2112609..2113934 (-) 1326 WP_024477997.1 competence system sensor histidine kinase ComD Regulator
  GL188_RS10785 (GL188_10960) comC/comC2 2113955..2114080 (-) 126 WP_000799694.1 competence-stimulating peptide ComC Regulator

Sequence

Protein


Download         Length: 41 a.a.        Molecular weight: 4892.93 Da        Isoelectric Point: 10.9061

>NTDB_id=403380 GL188_RS10785 WP_000799694.1 2113955..2114080(-) (comC/comC2) [Streptococcus pneumoniae strain 573]
MKNTVKLEQFVALKEKDLQNIKGGEMRISRIILDFLFLRKK

Nucleotide


Download         Length: 126 bp        

>NTDB_id=403380 GL188_RS10785 WP_000799694.1 2113955..2114080(-) (comC/comC2) [Streptococcus pneumoniae strain 573]
ATGAAAAACACAGTTAAATTGGAACAGTTTGTAGCTTTGAAGGAAAAAGACTTACAAAATATTAAAGGTGGGGAGATGAG
GATTTCAAGAATCATCCTTGATTTTCTTTTCCTACGAAAAAAGTAA

Domains

Predicted by InterproScan.

COMC family (ComC)

(1-29)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q9WW44

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comC/comC2 Streptococcus pneumoniae A66

97.561

100

0.976
  comC/comC2 Streptococcus pneumoniae TIGR4

97.561

100

0.976
  comC/comC1 Streptococcus pneumoniae R6

78.049

100

0.78
  comC/comC1 Streptococcus pneumoniae G54

78.049

100

0.78
  comC/comC1 Streptococcus pneumoniae D39

78.049

100

0.78
  comC/comC1 Streptococcus pneumoniae Rx1

78.049

100

0.78
  comC Streptococcus mitis SK321

75.61

100

0.756
  comC Streptococcus mitis NCTC 12261

60

97.561

0.585

Multiple sequence alignment