Detailed information NTG0403379

Bioinformatically predicted

Overview

• Name: comD/comD2
• Type: Regulator
• Locus tag: GL188_RS10780
• Genome accession: NZ_CP046359
• Coordinates: 2112609..2113934 (-)
• Length: 441 a.a.
• NCBI ID: WP_024477997.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain 573
• Function: phosphorylation of ComE (predicted from homology) Competence regulation

Genomic Context

Location: 2107609..2118934

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GL188_RS11365	-	2109293..2110896 (-)	1604	Protein_2103	YhgE/Pip family protein	-
GL188_RS10760 (GL188_10935)	-	2111075..2111617 (+)	543	WP_001158269.1	TetR/AcrR family transcriptional regulator	-
GL188_RS10775 (GL188_10950)	comE	2111860..2112612 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
GL188_RS10780 (GL188_10955)	comD/comD2	2112609..2113934 (-)	1326	WP_024477997.1	competence system sensor histidine kinase ComD	Regulator
GL188_RS10785 (GL188_10960)	comC/comC2	2113955..2114080 (-)	126	WP_000799694.1	competence-stimulating peptide ComC	Regulator

Sequence

Protein

• Length: 441 a.a.
• Molecular weight: 51489.09 Da
• Isoelectric Point: 7.5816

>NTDB_id=403379 GL188_RS10780 WP_024477997.1 2112609..2113934(-) (comD/comD2) [Streptococcus pneumoniae strain 573]
MDLLGFGTVIVHFLIISHSYRLICKGRINRKELYIFGAYTLLTEIVLEFSFYLLYLDKIGIERFLFPLGLYSYFRWMKQY
ERDRGLFLSLLLSLLYESTHNFLSVTFSSITGDNFVLQYHFPFFFVVTVLTYFVTLKIIYYFHLELAYFDKDYFYPFLKK
VFFALLLLHIVSFVSDMVSTIKHLNSFGSILSSIVFISLLLTFFAMNSHKVQMEKEIALKQKKFEQKHLQNYTDEIVGLY
NEIRGFRHDYAGMLVSMQMAIDSGNLQEIDRIYNEVLVKANHKLRSDKYTYFDLNNIEDSALRSLVAQSIVYARNNGVEF
TLEVKDTITKLPIELLDLVRIMSVLLNNAVEGSADSYKKQMEVAVIKMETETVMVIQNSCKMTMTPSGDLFALGFSTKGR
NRGVGLNNVKELLDKYNNIILETEMEGSTFRQIIRFKREFE

Nucleotide

• Length: 1326 bp

>NTDB_id=403379 GL188_RS10780 WP_024477997.1 2112609..2113934(-) (comD/comD2) [Streptococcus pneumoniae strain 573]
ATGGATTTACTTGGATTTGGGACAGTTATTGTTCATTTTTTAATTATTAGTCACAGTTACCGTTTAATTTGTAAAGGTCG
AATAAATAGAAAAGAATTATACATTTTTGGTGCTTATACATTACTAACTGAAATAGTACTTGAATTTTCCTTTTATCTTC
TATATTTAGATAAAATAGGGATTGAAAGATTTTTATTTCCTTTGGGCTTATATTCCTATTTTCGATGGATGAAACAGTAT
GAGAGGGATAGAGGACTATTCCTAAGTTTACTACTATCTCTTTTATATGAGAGCACTCATAACTTTCTGTCCGTAACTTT
CTCCTCTATAACAGGAGATAATTTTGTTTTACAATATCATTTCCCATTCTTTTTCGTTGTGACGGTGTTAACCTATTTTG
TTACATTAAAAATCATTTATTATTTCCATTTGGAACTAGCCTATTTTGACAAGGACTACTTTTATCCTTTCTTGAAAAAA
GTATTTTTTGCTTTACTATTGCTACATATTGTATCTTTCGTTTCAGATATGGTAAGTACGATTAAACATTTGAATAGTTT
TGGAAGTATTTTGTCATCTATTGTCTTTATCTCTCTCCTTTTGACCTTCTTTGCAATGAATTCTCATAAAGTTCAAATGG
AGAAAGAGATTGCTTTGAAGCAGAAGAAATTTGAACAGAAACATTTACAGAATTACACAGATGAAATTGTTGGTCTGTAT
AATGAAATCCGTGGTTTTCGACATGATTATGCTGGAATGCTTGTCAGCATGCAGATGGCAATTGACAGTGGTAATTTACA
GGAAATTGACAGAATTTACAATGAAGTTTTAGTCAAAGCAAATCATAAATTGCGTTCAGATAAGTACACTTACTTTGATT
TGAACAACATAGAAGACTCAGCTTTACGAAGTTTGGTTGCTCAGTCAATTGTCTATGCTCGAAATAATGGTGTAGAGTTT
ACACTGGAAGTAAAAGATACGATTACCAAGCTTCCAATTGAACTATTGGATTTGGTTCGTATCATGAGCGTTTTATTGAA
TAATGCTGTCGAAGGATCGGCTGATAGCTATAAAAAGCAGATGGAAGTAGCAGTTATTAAGATGGAAACTGAAACAGTTA
TGGTGATTCAGAATTCATGTAAAATGACGATGACTCCTTCAGGAGATCTATTTGCCTTAGGATTCTCCACTAAGGGAAGA
AATCGCGGAGTCGGATTAAATAATGTGAAAGAACTACTAGATAAGTACAACAATATTATTTTAGAAACAGAGATGGAAGG
CAGTACATTTAGACAAATCATTAGATTTAAGAGGGAATTTGAATGA

Domains

Predicted by InterproScan.

• GHKL domain (HATPase_c_5) (334-434)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comD/comD2	Streptococcus pneumoniae TIGR4	99.093	100	0.991
comD/comD1	Streptococcus pneumoniae Rx1	96.372	100	0.964
comD/comD1	Streptococcus pneumoniae D39	96.372	100	0.964
comD/comD1	Streptococcus pneumoniae R6	96.372	100	0.964
comD	Streptococcus mitis SK321	91.61	100	0.916
comD	Streptococcus mitis NCTC 12261	86.395	100	0.864
comD/comD2	Streptococcus gordonii strain NCTC7865	49.202	85.261	0.42
comD/comD1	Streptococcus gordonii str. Challis substr. CH1	49.465	84.807	0.419