Detailed information    

insolico Bioinformatically predicted

Overview

Name   micA   Type   Regulator
Locus tag   GL188_RS05945 Genome accession   NZ_CP046359
Coordinates   1189106..1189810 (-) Length   234 a.a.
NCBI ID   WP_000722076.1    Uniprot ID   Q9S1K0
Organism   Streptococcus pneumoniae strain 573     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1184106..1194810
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  GL188_RS05920 (GL188_06035) - 1184418..1186289 (-) 1872 WP_000150986.1 Eco57I restriction-modification methylase domain-containing protein -
  GL188_RS05925 (GL188_06040) - 1186364..1186618 (-) 255 WP_001809704.1 type II toxin-antitoxin system RelE family toxin -
  GL188_RS05930 (GL188_06045) relB 1186620..1186862 (-) 243 WP_000208080.1 type II toxin-antitoxin system RelB family antitoxin -
  GL188_RS05935 (GL188_06050) vicX 1186953..1187762 (-) 810 WP_001289493.1 MBL fold metallo-hydrolase Regulator
  GL188_RS05940 (GL188_06055) micB 1187764..1189113 (-) 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK Regulator
  GL188_RS05945 (GL188_06060) micA 1189106..1189810 (-) 705 WP_000722076.1 response regulator YycF Regulator
  GL188_RS05950 (GL188_06065) mutY 1189865..1191040 (-) 1176 WP_000886147.1 A/G-specific adenine glycosylase -
  GL188_RS11290 - 1191137..1191262 (+) 126 WP_001818232.1 hypothetical protein -
  GL188_RS05955 (GL188_06070) - 1191368..1193038 (-) 1671 WP_024477796.1 formate--tetrahydrofolate ligase -
  GL188_RS05960 (GL188_06075) coaB 1193268..1193957 (+) 690 WP_000699488.1 phosphopantothenate--cysteine ligase -
  GL188_RS05965 (GL188_06080) coaC 1193969..1194520 (+) 552 WP_001284128.1 phosphopantothenoylcysteine decarboxylase -

Sequence

Protein


Download         Length: 234 a.a.        Molecular weight: 26815.63 Da        Isoelectric Point: 4.7164

>NTDB_id=403333 GL188_RS05945 WP_000722076.1 1189106..1189810(-) (micA) [Streptococcus pneumoniae strain 573]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide


Download         Length: 705 bp        

>NTDB_id=403333 GL188_RS05945 WP_000722076.1 1189106..1189810(-) (micA) [Streptococcus pneumoniae strain 573]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA
AGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC
AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACGAAACCCTTCTCCAATCGTGA
GTTGCAGGCGCGTGTTAAAGCTCTTCTGCGTCGTTCTCAACCTATGCCAGTAGATGGGCAGGAAGCAGATAGTAAACCTC
AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGTACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(154-229)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  PDB 1NXS
  PDB 2A9O
  PDB 2A9P

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  micA Streptococcus pneumoniae Cp1015

100

100

1
  vicR Streptococcus mutans UA159

78.541

99.573

0.782
  covR Streptococcus salivarius strain HSISS4

44.156

98.718

0.436
  covR Lactococcus lactis subsp. lactis strain DGCC12653

43.478

98.291

0.427
  scnR Streptococcus mutans UA159

38.197

99.573

0.38

Multiple sequence alignment