Detailed information NTG0403249

Bioinformatically predicted

Overview

• Name: coiA
• Type: Machinery gene
• Locus tag: GL186_RS04465
• Genome accession: NZ_CP046358
• Coordinates: 877466..878419 (+)
• Length: 317 a.a.
• NCBI ID: WP_000495911.1
• Uniprot ID: Q8DQ27
• Organism: Streptococcus pneumoniae strain 566
• Function: homologous recombination (predicted from homology) Homologous recombination

Genomic Context

Location: 872466..883419

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GL186_RS04440 (GL186_04560)	rpmG	873209..873358 (+)	150	WP_001809104.1	50S ribosomal protein L33	-
GL186_RS04445 (GL186_04565)	secG	873398..873631 (+)	234	WP_000282517.1	preprotein translocase subunit SecG	-
GL186_RS04450 (GL186_04570)	rnr	873733..876087 (+)	2355	WP_024477774.1	ribonuclease R	-
GL186_RS04455 (GL186_04575)	smpB	876050..876517 (+)	468	WP_001051750.1	SsrA-binding protein SmpB	-
GL186_RS04460 (GL186_04580)	tehB	876533..877393 (+)	861	WP_000413762.1	SAM-dependent methyltransferase TehB	-
GL186_RS04465 (GL186_04585)	coiA	877466..878419 (+)	954	WP_000495911.1	competence protein CoiA	Machinery gene
GL186_RS04470 (GL186_04590)	pepF	878438..880240 (+)	1803	WP_024477773.1	oligoendopeptidase F	Regulator
GL186_RS04475 (GL186_04595)	-	880242..880955 (+)	714	WP_000230399.1	O-methyltransferase	-
GL186_RS04480 (GL186_04600)	prsA	881022..881963 (+)	942	WP_000727935.1	peptidylprolyl isomerase PrsA	-
GL186_RS04485 (GL186_04605)	-	882082..882423 (-)	342	Protein_898	transposase	-
GL186_RS04490 (GL186_04610)	-	882835..882930 (+)	96	Protein_899	IS630 family transposase	-

Sequence

Protein

• Length: 317 a.a.
• Molecular weight: 38143.79 Da
• Isoelectric Point: 9.1135

>NTDB_id=403249 GL186_RS04465 WP_000495911.1 877466..878419(+) (coiA) [Streptococcus pneumoniae strain 566]
MFVARDARGELVNVLEDKLEKQAYTCPACGGQLHLRQGPSVRTHFAHKSLKDCDFFFENESPEHLANKESLYHWLKKETK
VQLEYPLSELKQIADVFVNGNLALEVQCSPLPQKVLKERSEGYRSQGYQVLWLLGQKLWLKERLTRLQQGFLYFSQNMGF
YVWELDKGKQVLRLKYLIYQDLRGKLHYQIKEFSYGQGSLLEILRLPYKKQKISHFTVSEDKDICRYIRQQLYYQNLFWM
KEQAEAYQKGENILTYGLKEWYPQIRPIVGKFFQIEQDLTSYYQHFYTYYQKNPQNDWQKLYPPAFYQQYFLKNMVE

Nucleotide

• Length: 954 bp

>NTDB_id=403249 GL186_RS04465 WP_000495911.1 877466..878419(+) (coiA) [Streptococcus pneumoniae strain 566]
ATGTTTGTTGCGAGAGATGCTAGGGGAGAATTGGTAAATGTGTTAGAGGATAAACTTGAGAAGCAAGCATACACCTGCCC
AGCTTGTGGAGGCCAGCTCCATTTGCGTCAAGGACCAAGTGTACGGACGCATTTTGCCCATAAATCTTTAAAAGACTGTG
ATTTTTTCTTTGAAAATGAAAGTCCAGAACACCTGGCCAATAAGGAATCCCTCTATCACTGGTTGAAAAAAGAGACAAAG
GTTCAATTAGAGTACCCGCTTTCAGAACTTAAACAGATTGCGGATGTATTTGTAAATGGCAATCTAGCTCTAGAAGTTCA
GTGTAGTCCCTTGCCTCAGAAAGTCCTTAAAGAGCGAAGTGAGGGCTATCGTAGTCAGGGTTACCAAGTACTGTGGTTGC
TGGGTCAAAAACTGTGGCTCAAGGAGCGTTTGACTCGTCTACAGCAAGGTTTTCTTTATTTCAGTCAAAACATGGGCTTT
TATGTTTGGGAATTAGACAAGGGAAAACAAGTTTTAAGACTCAAATACCTGATTTACCAGGATCTCCGCGGTAAACTCCA
TTATCAAATCAAGGAATTTTCCTATGGCCAAGGTAGTTTATTGGAAATATTGCGTCTTCCCTATAAGAAACAAAAAATAT
CTCATTTTACAGTTTCTGAGGACAAGGACATCTGTCGCTATATCCGGCAACAACTTTATTATCAAAATCTCTTTTGGATG
AAAGAACAAGCAGAAGCCTATCAAAAGGGAGAAAATATCCTGACTTATGGACTGAAAGAATGGTATCCACAAATTCGACC
AATAGTGGGCAAATTTTTCCAGATTGAACAAGACTTGACTAGCTATTATCAGCACTTTTATACCTATTACCAAAAAAATC
CTCAAAATGATTGGCAAAAGCTTTATCCACCAGCCTTTTATCAGCAATATTTCTTGAAAAATATGGTAGAATAG

Domains

Predicted by InterproScan.

• Competence protein CoiA-like family (CoiA_nuc) (13-263)

3D structure

• AlphaFold DB: Q8DQ27

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
coiA	Streptococcus pneumoniae Rx1	100	100	1
coiA	Streptococcus pneumoniae D39	100	100	1
coiA	Streptococcus pneumoniae R6	100	100	1
coiA	Streptococcus pneumoniae TIGR4	99.369	100	0.994
coiA	Streptococcus mitis NCTC 12261	89.274	100	0.893
coiA	Lactococcus lactis subsp. cremoris KW2	42.593	100	0.435