Detailed information NTG0403163

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: GL185_RS03860
• Genome accession: NZ_CP046357
• Coordinates: 771992..772666 (-)
• Length: 224 a.a.
• NCBI ID: WP_000590640.1
• Uniprot ID: D4I4V1
• Organism: Streptococcus pneumoniae strain 525
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IS/Tn	772884..774140	771992..772666	flank	218

Gene organization within MGE regions

Location: 771992..774140

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GL185_RS03860 (GL185_03900)	ciaR	771992..772666 (-)	675	WP_000590640.1	two-component system response regulator CiaR	Regulator
GL185_RS03865 (GL185_03910)	-	772884..774140 (+)	1257	WP_197097732.1	ISL3-like element IS1167A family transposase	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25466.29 Da
• Isoelectric Point: 4.3283

>NTDB_id=403163 GL185_RS03860 WP_000590640.1 771992..772666(-) (ciaR) [Streptococcus pneumoniae strain 525]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLTYGNIVVNLSTNTVKVEDTPVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKVRKKLKGTTFAENLQTLRSVGYLLKDVQ

Nucleotide

• Length: 675 bp

>NTDB_id=403163 GL185_RS03860 WP_000590640.1 771992..772666(-) (ciaR) [Streptococcus pneumoniae strain 525]
ATGATAAAAATCTTATTGGTTGAGGATGACCTAGGTCTGTCAAATTCAGTATTTGACTTTTTAGACGATTTTGCGGATGT
TATGCAGGTATTTGATGGAGAAGAAGGTCTCTACGAAGCTGAGAGTGGTGTCTATGACTTGATTTTGCTGGATTTGATGT
TGCCAGAAAAAAATGGTTTCCAAGTCTTAAAAGAATTGCGTGAAAAGGGAATTACGACACCAGTTCTGATTATGACTGCC
AAGGAAAGTTTGGATGACAAGGGACATGGATTTGAACTGGGAGCGGATGATTATCTGACCAAACCTTTCTACCTAGAAGA
ACTTAAAATGCGAATTCAGGCCCTTCTCAAACGTTCAGGGAAGTTTAATGAAAACACCTTGACTTATGGGAATATCGTGG
TTAATTTATCAACCAATACCGTTAAAGTTGAAGATACTCCTGTCGAATTGCTGGGGAAAGAGTTCGATTTACTAGTTTAT
TTCCTTCAAAATCAAAATGTGATTTTGCCTAAGACGCAGATTTTTGACCGTCTATGGGGATTTGATAGTGATACAACGAT
TTCGGTTGTCGAAGTCTATGTTTCAAAAGTCCGTAAGAAATTAAAGGGAACCACTTTTGCAGAGAATTTGCAAACCTTGC
GTAGTGTTGGGTATCTTTTAAAAGATGTTCAGTAA

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (146-220)

• Response regulator receiver domain (Response_reg) (4-112)

3D structure

• AlphaFold DB: D4I4V1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus pneumoniae Rx1	100	100	1
ciaR	Streptococcus pneumoniae D39	100	100	1
ciaR	Streptococcus pneumoniae R6	100	100	1
ciaR	Streptococcus pneumoniae TIGR4	100	100	1
ciaR	Streptococcus mutans UA159	88.393	100	0.884
covR	Lactococcus lactis subsp. lactis strain DGCC12653	36.726	100	0.371
vicR	Streptococcus mutans UA159	35.622	100	0.371