Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA   Type   Regulator
Locus tag   GL184_RS10620 Genome accession   NZ_CP046356
Coordinates   2090088..2092241 (-) Length   717 a.a.
NCBI ID   WP_000668280.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain 521     
Function   processing and transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 2085088..2097241
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  GL184_RS10610 (GL184_10780) purC 2087849..2088556 (-) 708 WP_000043301.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
  GL184_RS10615 (GL184_10785) comB 2088726..2090075 (-) 1350 WP_024477962.1 competence pheromone export protein ComB Regulator
  GL184_RS10620 (GL184_10790) comA 2090088..2092241 (-) 2154 WP_000668280.1 peptide cleavage/export ABC transporter ComA Regulator
  GL184_RS10625 (GL184_10795) - 2092621..2093112 (-) 492 WP_000671990.1 hypothetical protein -
  GL184_RS10630 (GL184_10800) - 2093093..2093689 (-) 597 WP_000687787.1 ATP-binding cassette domain-containing protein -
  GL184_RS10635 (GL184_10805) - 2093686..2094168 (-) 483 WP_001232094.1 stage II sporulation protein M -
  GL184_RS10640 (GL184_10810) - 2094165..2095301 (-) 1137 WP_000698828.1 hypothetical protein -
  GL184_RS10645 (GL184_10815) - 2095308..2095604 (-) 297 WP_000837726.1 uberolysin/carnocyclin family circular bacteriocin -
  GL184_RS10650 (GL184_10820) - 2096147..2097040 (-) 894 WP_000343888.1 helix-turn-helix domain-containing protein -

Sequence

Protein


Download         Length: 717 a.a.        Molecular weight: 80374.42 Da        Isoelectric Point: 6.4567

>NTDB_id=403144 GL184_RS10620 WP_000668280.1 2090088..2092241(-) (comA) [Streptococcus pneumoniae strain 521]
MKFGKRHYRPQVDQMDCGVASLAMVFGYYGSYYFLAHLRELAKTTMDGTTALGLVKVAEEIGFETRAIKADMTLFDLPDL
TFPFVAHVLKEGKLLHYYVVTGQDKDSIHIADPDPGVKLTKLPRERFAEEWTGVTLFMAPSPDYKPHKEQKNGLFSFIPI
LVKQRGLIANIVLATLLVTVINIVGSYYLQSIIDTYVPDQMRSTLGIISIGLVIVYILQQILSYAQEYLLLVLGQRLSID
VILSYIKHVFHLPMSFFATRRTGEIVSRFTDANSIIDALASTILSIFLDVSTVVIISLVLFSQNTNLFFMTLLALPIYTV
IIFAFMKPFEKMNRDTMEANAVLSSSIIEDINGIETIKSLTSESQRYQKIDKEFVDYLKKSFTYSRAESQQKALKKVAHL
LLNVGILWMGAVLVMDGKMSLGQLITYNTLLVYFTNPLENIINLQTKLQTAQVANNRLNEVYLVASEFEEKKTVEDLSLM
KGDMTFKQVHYKYGYGRDVLSDINLTVPQGSKVAFVGISGSGKTTLAKMMVNFYDPSQGEISLGSVNLNQIDKKALRQYI
NYLPQQPYVFNGTILENLLLGAKEGTTQEDILRAVELAEIREDIERMPLNYQTELTSDGAGISGGQRQRIALARALLTDA
PVLILDEATSSLDILTEKRIVDNLMALDKTLIFIAHRLTIAERTEKVVVLDQGKIVEEGKHADLLAQGGFYAHLVNS

Nucleotide


Download         Length: 2154 bp        

>NTDB_id=403144 GL184_RS10620 WP_000668280.1 2090088..2092241(-) (comA) [Streptococcus pneumoniae strain 521]
ATGAAATTTGGGAAACGTCACTATCGTCCGCAAGTGGATCAGATGGACTGCGGTGTAGCTTCATTAGCCATGGTTTTTGG
CTACTATGGTAGTTATTATTTTTTGGCTCACTTGCGAGAATTGGCTAAGACGACCATGGATGGGACGACGGCTTTGGGCT
TGGTCAAGGTGGCAGAGGAGATTGGTTTTGAGACGCGAGCCATTAAGGCGGATATGACGCTTTTTGACTTGCCGGATTTG
ACTTTTCCTTTTGTTGCCCATGTGCTTAAGGAAGGGAAATTGCTCCACTACTATGTGGTGACTGGGCAGGATAAGGATAG
CATTCATATTGCCGACCCAGATCCTGGGGTGAAATTGACTAAACTGCCACGTGAGCGTTTTGCGGAAGAATGGACAGGAG
TGACTCTTTTTATGGCACCTAGTCCAGACTACAAGCCTCATAAGGAACAAAAAAATGGTCTGTTCTCTTTTATCCCTATA
TTAGTGAAGCAGCGTGGCTTGATTGCCAATATCGTTTTGGCAACACTCTTGGTAACCGTGATTAACATTGTGGGTTCTTA
TTATCTGCAGTCTATCATTGATACCTATGTGCCAGATCAGATGCGTTCGACACTAGGGATTATTTCTATTGGGCTAGTCA
TCGTCTACATCCTCCAGCAAATCTTGTCTTACGCTCAGGAGTATCTCTTGCTTGTTTTGGGGCAACGCTTGTCGATTGAC
GTGATTTTGTCCTATATCAAGCATGTTTTTCACCTCCCTATGTCCTTCTTTGCGACACGCAGGACAGGGGAGATCGTGTC
TCGTTTTACAGATGCTAACAGTATCATCGATGCGCTGGCTTCGACCATCCTTTCGATTTTCCTAGATGTGTCAACGGTTG
TCATTATTTCCCTTGTTCTATTTTCACAAAATACCAATCTCTTTTTCATGACTTTATTGGCGCTTCCTATCTACACAGTG
ATTATCTTTGCCTTTATGAAGCCGTTTGAAAAGATGAATCGGGATACCATGGAAGCCAATGCGGTTCTGTCTTCTTCTAT
CATTGAGGACATCAACGGTATTGAGACTATCAAGTCCTTGACCAGTGAAAGTCAGCGTTACCAAAAAATTGACAAGGAAT
TTGTGGATTATCTGAAGAAATCCTTTACCTATAGTCGAGCAGAGAGTCAGCAAAAGGCTCTGAAAAAGGTTGCCCATCTC
TTGCTTAATGTCGGCATTCTCTGGATGGGGGCTGTTCTGGTCATGGATGGCAAGATGAGTTTGGGGCAGTTGATTACCTA
TAATACCTTGCTGGTTTACTTTACCAATCCTTTGGAAAATATCATCAATCTGCAAACCAAGCTTCAGACAGCGCAGGTTG
CCAATAACCGTCTAAATGAAGTGTATCTAGTAGCTTCTGAGTTTGAGGAGAAGAAAACAGTTGAGGATTTGAGCTTGATG
AAGGGAGATATGACCTTCAAGCAGGTTCATTACAAGTATGGCTATGGTCGAGACGTCTTGTCGGATATCAATTTAACCGT
TCCCCAAGGGTCTAAGGTGGCTTTTGTGGGGATTTCAGGGTCAGGTAAGACGACTTTGGCCAAGATGATGGTTAATTTTT
ACGACCCAAGTCAAGGGGAGATTAGTCTGGGTAGTGTCAATCTCAATCAGATTGATAAAAAAGCCCTGCGCCAGTACATC
AACTATCTGCCTCAACAGCCCTATGTCTTTAACGGAACGATTTTGGAGAATCTTCTTTTGGGAGCCAAGGAGGGGACGAC
ACAGGAAGATATCTTACGGGCGGTCGAATTGGCAGAGATTCGAGAGGATATCGAGCGCATGCCACTGAATTATCAGACAG
AATTGACTTCGGATGGGGCAGGGATTTCAGGTGGTCAACGTCAGAGAATCGCTTTGGCGCGTGCTCTCTTGACAGATGCG
CCGGTCTTGATTTTGGATGAGGCGACTAGCAGTTTGGATATTTTGACAGAGAAGCGGATTGTCGATAATCTCATGGCTTT
GGACAAGACCTTGATTTTCATTGCTCACCGCTTGACTATTGCTGAGCGGACAGAGAAGGTGGTTGTCTTGGATCAGGGCA
AGATTGTCGAAGAAGGAAAGCATGCTGATTTGCTTGCACAGGGAGGCTTTTACGCCCATTTGGTCAATAGCTAG

Domains

Predicted by InterproScan.

ABC transporter (ABC_tran)

(500-650)

Peptidase C39 family (Peptidase_C39)

(7-142)

ABC transporter transmembrane region (ABC_membrane)

(170-438)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA Streptococcus pneumoniae Rx1

99.442

100

0.994
  comA Streptococcus pneumoniae D39

99.442

100

0.994
  comA Streptococcus pneumoniae R6

99.442

100

0.994
  comA Streptococcus pneumoniae TIGR4

99.303

100

0.993
  comA Streptococcus mitis SK321

98.466

100

0.985
  comA Streptococcus mitis NCTC 12261

98.466

100

0.985
  comA Streptococcus gordonii str. Challis substr. CH1

80.335

100

0.803
  comA/nlmT Streptococcus mutans UA159

64.714

100

0.647

Multiple sequence alignment