Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA   Type   Regulator
Locus tag   FOB92_RS00195 Genome accession   NZ_CP046335
Coordinates   39688..41841 (+) Length   717 a.a.
NCBI ID   WP_000668315.1    Uniprot ID   -
Organism   Streptococcus mitis strain FDAARGOS_684     
Function   processing and transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 34688..46841
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  FOB92_RS09070 - 36405..37220 (+) 816 WP_000184940.1 GHKL domain-containing protein -
  FOB92_RS00170 (FOB92_00170) - 37217..37948 (+) 732 WP_001221869.1 response regulator transcription factor -
  FOB92_RS00175 (FOB92_00175) - 38194..38322 (+) 129 WP_000658220.1 smi_0059.1 family bacteriocin-like peptide -
  FOB92_RS00180 (FOB92_00180) - 38334..38489 (+) 156 WP_001004642.1 hypothetical protein -
  FOB92_RS00185 (FOB92_00185) - 38523..38696 (+) 174 WP_000180829.1 class IIb bacteriocin, lactobin A/cerein 7B family -
  FOB92_RS00190 (FOB92_00190) - 38820..38972 (+) 153 WP_001180497.1 class IIb bacteriocin, lactobin A/cerein 7B family -
  FOB92_RS09000 - 38997..39152 (+) 156 WP_000732248.1 hypothetical protein -
  FOB92_RS00195 (FOB92_00195) comA 39688..41841 (+) 2154 WP_000668315.1 peptide cleavage/export ABC transporter ComA Regulator
  FOB92_RS00200 (FOB92_00200) comB 41854..43203 (+) 1350 WP_000801588.1 competence pheromone export protein ComB Regulator
  FOB92_RS00205 (FOB92_00205) purC 43373..44080 (+) 708 WP_000043282.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
  FOB92_RS09205 - 44082..44225 (+) 144 WP_078228447.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -

Sequence

Protein


Download         Length: 717 a.a.        Molecular weight: 80194.19 Da        Isoelectric Point: 6.2574

>NTDB_id=402771 FOB92_RS00195 WP_000668315.1 39688..41841(+) (comA) [Streptococcus mitis strain FDAARGOS_684]
MKFGKRHYRPQVDQMDCGVASLAMVFGYYGSYYSLAHLRELAKTTMDGTTALGLVKVAEEIGFETRAIKADMTLFDLPDL
TFPFVAHVLKEGKLLHYYVVTGQDKDSIHIADPDPGVKLTKLPRERFAEEWTGVTLFMAPSPDYKPHKDQKNGLLSFIPI
LVKQRGLIANIVLATLLVTLINIVGSYYLQSIIDTYVPDQMRSTLGIISIGLVIVYILQQILSYAQEYLLLVLGQRLSID
VILSYIKHVFHLPMSFFATRRTGEIVSRFTDANSIIDALASTILSIFLDVSTVVIISLVLFSQNTNLFFITLLALPIYTV
IIFAFMKPFEKMNRDTMEANAVLSSSIIEDINGIETIKSLTSESQRYQKIDKEFVDYLKKSFTYSRAESQQKALKKVAHL
LLNVGILWMGAVLVMDGKMSLGQLITYNTLLVYFTNPLENIINLQTKLQTAQVANNRLNEVYLVASEFEEKKTVEDLSLM
KGDMTFKQVSYKYGYGRDVLLDINLTIPQGSKVAFVGISGSGKTTLAKMMVNFYDPSQGEISLGGVNLNQIDKKALRQYI
NYLPQQPYVFNGTILDNLLLGAKEGTTQEDILRAVELAEIREDIERMPLNYQTELTSDGAGISGGQRQRIALARALLTDA
PVLILDEATSSLDILTEKRIVDNLMALDKTLIFIAHRLTIAERTEKVVVLDQGKIVEEGNHADLLAQGGFYAHLVNS

Nucleotide


Download         Length: 2154 bp        

>NTDB_id=402771 FOB92_RS00195 WP_000668315.1 39688..41841(+) (comA) [Streptococcus mitis strain FDAARGOS_684]
ATGAAATTTGGGAAACGTCACTATCGTCCGCAAGTGGATCAGATGGACTGCGGTGTAGCTTCATTAGCCATGGTTTTTGG
TTACTATGGTAGTTATTATTCTTTGGCACACTTACGAGAATTGGCCAAGACGACCATGGATGGGACGACGGCTTTGGGCT
TGGTCAAGGTGGCAGAGGAGATTGGTTTTGAGACGCGAGCAATTAAGGCGGATATGACGCTTTTTGACTTGCCAGATTTG
ACTTTTCCTTTTGTTGCTCATGTGCTTAAGGAAGGGAAATTGCTCCACTACTATGTGGTGACTGGGCAGGACAAGGATAG
CATTCATATTGCCGATCCAGATCCTGGGGTGAAATTGACCAAACTGCCACGTGAGCGTTTTGCGGAAGAATGGACAGGAG
TGACTCTTTTTATGGCACCTAGTCCAGACTACAAGCCTCATAAGGATCAAAAGAATGGTCTGCTCTCTTTTATCCCTATA
TTAGTGAAGCAGCGTGGCTTGATTGCCAATATCGTTTTGGCAACACTCTTGGTAACCTTGATTAATATTGTGGGTTCTTA
TTATCTGCAGTCTATCATTGATACCTATGTGCCAGATCAGATGCGTTCGACGCTTGGGATTATTTCTATTGGGCTGGTGA
TTGTTTATATTCTTCAGCAGATCTTGTCTTACGCTCAGGAGTATCTCTTACTTGTTTTGGGGCAACGCTTATCGATTGAT
GTGATTTTGTCCTATATCAAGCATGTTTTTCACCTGCCTATGTCCTTCTTTGCGACACGCAGGACAGGGGAGATCGTGTC
TCGTTTTACAGATGCTAATAGTATCATTGATGCGCTGGCTTCGACCATTCTTTCGATTTTCCTAGATGTGTCAACGGTTG
TCATTATTTCCCTTGTTTTATTTTCACAAAATACCAATCTCTTTTTCATAACCTTATTGGCACTTCCTATCTATACAGTG
ATTATCTTTGCCTTTATGAAGCCGTTTGAAAAGATGAATCGGGATACCATGGAAGCCAATGCGGTTCTGTCTTCTTCTAT
CATTGAGGACATCAACGGTATTGAGACTATCAAGTCTTTGACCAGTGAAAGTCAGCGTTACCAAAAGATTGACAAGGAAT
TTGTGGATTATCTGAAAAAATCCTTTACCTATAGTCGGGCAGAGAGTCAGCAAAAGGCTCTGAAAAAAGTTGCCCATCTC
TTACTCAATGTCGGCATTCTCTGGATGGGAGCTGTTCTGGTCATGGATGGCAAGATGAGTTTGGGGCAGTTGATTACCTA
TAATACCTTGCTGGTTTACTTTACAAATCCTTTGGAAAATATCATCAATCTGCAAACCAAGCTTCAGACAGCACAGGTTG
CCAATAACCGTCTAAATGAAGTATATCTGGTAGCTTCGGAGTTTGAGGAGAAGAAAACGGTTGAGGATTTGAGCTTGATG
AAGGGAGATATGACCTTCAAGCAGGTTTCTTACAAGTATGGCTATGGTCGAGACGTCTTGTTGGATATCAATTTGACCAT
TCCCCAAGGTTCTAAGGTGGCTTTTGTGGGGATTTCAGGGTCAGGTAAGACGACCTTGGCCAAGATGATGGTTAATTTTT
ACGACCCAAGTCAAGGGGAGATTAGTCTGGGTGGTGTCAATCTCAATCAGATTGATAAAAAGGCCTTGCGCCAGTATATC
AACTATCTGCCTCAACAGCCCTATGTCTTTAACGGAACGATTTTGGACAATCTTCTTTTGGGAGCCAAGGAGGGGACGAC
ACAGGAAGATATCTTACGGGCGGTCGAATTGGCAGAGATTCGGGAGGACATTGAGCGCATGCCACTGAATTACCAGACAG
AATTGACTTCGGATGGGGCAGGGATCTCAGGTGGTCAACGTCAGAGAATTGCTCTGGCACGTGCTCTCTTGACAGATGCG
CCGGTCTTGATCTTGGATGAGGCGACCAGCAGTTTGGATATTCTGACAGAGAAGCGAATTGTCGATAATCTTATGGCTTT
AGATAAGACCTTGATTTTCATCGCTCACCGCTTGACCATTGCTGAGCGGACAGAGAAGGTTGTTGTCTTGGATCAGGGCA
AGATTGTTGAAGAAGGAAATCATGCTGATTTGCTTGCACAGGGTGGTTTTTACGCCCATTTGGTCAATAGCTAG

Domains

Predicted by InterproScan.

ABC transporter (ABC_tran)

(502-650)

Peptidase C39 family (Peptidase_C39)

(7-142)

ABC transporter transmembrane region (ABC_membrane)

(170-438)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA Streptococcus mitis NCTC 12261

100

100

1
  comA Streptococcus mitis SK321

98.466

100

0.985
  comA Streptococcus pneumoniae Rx1

98.466

100

0.985
  comA Streptococcus pneumoniae D39

98.466

100

0.985
  comA Streptococcus pneumoniae R6

98.466

100

0.985
  comA Streptococcus pneumoniae TIGR4

98.047

100

0.98
  comA Streptococcus gordonii str. Challis substr. CH1

80.753

100

0.808
  comA/nlmT Streptococcus mutans UA159

65.411

100

0.654

Multiple sequence alignment