Detailed information NTG0401539

Bioinformatically predicted

Overview

• Name: mecA
• Type: Regulator
• Locus tag: GKC13_RS08615
• Genome accession: NZ_CP046134
• Coordinates: 1680269..1681018 (-)
• Length: 249 a.a.
• NCBI ID: WP_207559732.1
• Uniprot ID: A0A3G6K130
• Organism: Streptococcus thermophilus strain MAG_rmk202_sterm
• Function: degradation of ComX (predicted from homology) Competence regulation

Genomic Context

Location: 1675269..1686018

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GKC13_RS08595 (GKC13_08720)	-	1675592..1676824 (-)	1233	WP_011225367.1	cysteine desulfurase	-
GKC13_RS08600 (GKC13_08725)	sufD	1676878..1678140 (-)	1263	WP_011680669.1	Fe-S cluster assembly protein SufD	-
GKC13_RS08605 (GKC13_08730)	sufC	1678177..1678947 (-)	771	WP_002947634.1	Fe-S cluster assembly ATPase SufC	-
GKC13_RS08610 (GKC13_08735)	-	1679108..1680265 (-)	1158	WP_207559733.1	MraY family glycosyltransferase	-
GKC13_RS08615 (GKC13_08740)	mecA	1680269..1681018 (-)	750	WP_207559732.1	adaptor protein MecA	Regulator
GKC13_RS08620 (GKC13_08745)	-	1681302..1681499 (+)	198	WP_224103664.1	DUF3021 family protein	-
GKC13_RS08625 (GKC13_08750)	-	1681645..1682499 (-)	855	WP_041828107.1	undecaprenyl-diphosphate phosphatase	-
GKC13_RS08630 (GKC13_08755)	-	1682702..1684252 (+)	1551	WP_014607891.1	ABC transporter substrate-binding protein/permease	-
GKC13_RS08635 (GKC13_08760)	-	1684252..1684992 (+)	741	WP_002949253.1	amino acid ABC transporter ATP-binding protein	-
GKC13_RS10575 (GKC13_08765)	-	1685079..1685186 (-)	108	WP_011226802.1	LPXTG cell wall anchor domain-containing protein	-
GKC13_RS08645	-	1685273..1685443 (-)	171	WP_011680664.1	hypothetical protein	-

Sequence

Protein

• Length: 249 a.a.
• Molecular weight: 29201.71 Da
• Isoelectric Point: 4.0481

>NTDB_id=401539 GKC13_RS08615 WP_207559732.1 1680269..1681018(-) (mecA) [Streptococcus thermophilus strain MAG_rmk202_sterm]
MEMKQINETTLKIMITMEDLEEHGMELKDFLIPQEKTEEFFYTVMDELDLPDNFKNSGMLSFRVTPRKDRVDVFVTKSDL
KEDLDFNDLSDMEDYSGLSPEEFLKALEDNFMDKGDIEAHHKLEEHDKTLKEVDETMTEPAKEVAEETIREDYTHYVLAF
SDFDQVVTFAQGLKNVSVEGSEFYKLGDVYYMTILLYLADEPDYYANNMYARFLEYANVADRTRPYLQEHATILMEEDAL
PVLQATKWS

Nucleotide

• Length: 750 bp

>NTDB_id=401539 GKC13_RS08615 WP_207559732.1 1680269..1681018(-) (mecA) [Streptococcus thermophilus strain MAG_rmk202_sterm]
ATGGAAATGAAACAAATAAACGAGACAACTCTAAAAATCATGATTACCATGGAAGATCTTGAAGAACATGGTATGGAGCT
GAAAGATTTCTTGATTCCCCAGGAAAAAACAGAGGAATTTTTCTATACTGTCATGGATGAGTTGGACTTGCCTGATAACT
TTAAAAATAGTGGGATGTTGAGCTTCCGTGTCACGCCACGAAAGGATCGTGTGGATGTTTTTGTGACTAAATCAGATCTT
AAGGAAGACCTTGATTTCAATGATTTGTCAGATATGGAAGACTATTCAGGACTTTCTCCAGAAGAATTCCTCAAAGCTCT
TGAAGATAACTTTATGGATAAGGGAGATATTGAAGCCCACCATAAGCTCGAAGAGCATGATAAGACCTTGAAAGAGGTTG
ATGAGACTATGACAGAGCCGGCTAAGGAAGTGGCTGAGGAAACTATTCGTGAAGATTATACTCACTATGTCTTGGCTTTC
TCTGACTTTGATCAAGTAGTGACCTTTGCGCAAGGTTTGAAGAATGTGTCAGTGGAGGGTTCTGAATTTTATAAACTTGG
TGATGTCTACTATATGACTATCCTTCTTTACTTGGCTGATGAGCCTGATTATTACGCGAACAATATGTATGCGCGTTTTC
TTGAATATGCGAATGTGGCAGACCGAACACGTCCCTATCTACAAGAGCATGCAACAATCTTGATGGAAGAGGACGCCTTA
CCGGTATTACAAGCAACGAAATGGAGCTAG

Domains

Predicted by InterproScan.

• Negative regulator of genetic competence (MecA) (MecA) (1-242)

3D structure

• AlphaFold DB: A0A3G6K130

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
mecA	Streptococcus thermophilus LMD-9	99.598	100	0.996
mecA	Streptococcus thermophilus LMG 18311	99.598	100	0.996
mecA	Streptococcus mutans UA159	57.377	97.992	0.562
mecA	Streptococcus pneumoniae Rx1	46.185	100	0.462
mecA	Streptococcus pneumoniae D39	46.185	100	0.462
mecA	Streptococcus pneumoniae R6	46.185	100	0.462
mecA	Streptococcus pneumoniae TIGR4	46.185	100	0.462