Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/comE1   Type   Regulator
Locus tag   SGGBAA2069_RS10065 Genome accession   NC_015215
Coordinates   2021332..2022063 (-) Length   243 a.a.
NCBI ID   WP_013643488.1    Uniprot ID   A0A1H9V500
Organism   Streptococcus gallolyticus subsp. gallolyticus ATCC BAA-2069     
Function   activate transcription of early competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 2016332..2027063
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SGGBAA2069_RS10030 (SGGBAA2069_c19630) comE/comE2 2017111..2017839 (-) 729 WP_043913786.1 LytR/AlgR family response regulator transcription factor Regulator
  SGGBAA2069_RS10035 (SGGBAA2069_c19640) - 2017937..2018230 (-) 294 WP_009854994.1 bacteriocin immunity protein -
  SGGBAA2069_RS10040 (SGGBAA2069_c19650) - 2018281..2018508 (-) 228 WP_013643481.1 hypothetical protein -
  SGGBAA2069_RS10045 (SGGBAA2069_c19670) - 2018777..2019088 (-) 312 WP_003066564.1 bacteriocin immunity protein -
  SGGBAA2069_RS10050 (SGGBAA2069_c19680) - 2019100..2019249 (-) 150 WP_013643483.1 hypothetical protein -
  SGGBAA2069_RS10055 (SGGBAA2069_c19690) - 2019306..2019557 (-) 252 WP_231844599.1 DUF3884 family protein -
  SGGBAA2069_RS12190 (SGGBAA2069_c19710) - 2019858..2020028 (+) 171 WP_013643486.1 hypothetical protein -
  SGGBAA2069_RS10060 (SGGBAA2069_c19720) - 2020017..2021327 (-) 1311 WP_013643487.1 sensor histidine kinase -
  SGGBAA2069_RS10065 (SGGBAA2069_c19730) comE/comE1 2021332..2022063 (-) 732 WP_013643488.1 response regulator transcription factor Regulator
  SGGBAA2069_RS10070 - 2022080..2022406 (-) 327 WP_009855002.1 LytTR family DNA-binding domain-containing protein -
  SGGBAA2069_RS10075 (SGGBAA2069_c19740) - 2022590..2023882 (-) 1293 WP_013643489.1 glycosyltransferase family 2 protein -
  SGGBAA2069_RS10080 (SGGBAA2069_c19750) - 2023884..2024183 (-) 300 WP_013643490.1 DUF3884 family protein -
  SGGBAA2069_RS10085 (SGGBAA2069_c19760) - 2024209..2024391 (-) 183 WP_013643491.1 hypothetical protein -
  SGGBAA2069_RS10090 (SGGBAA2069_c19770) - 2024473..2024682 (-) 210 WP_013643492.1 helix-turn-helix domain-containing protein -
  SGGBAA2069_RS10095 (SGGBAA2069_c19780) - 2024672..2025685 (-) 1014 WP_013643493.1 thiol reductase thioredoxin -
  SGGBAA2069_RS10100 (SGGBAA2069_c19790) - 2026062..2026259 (-) 198 WP_009855009.1 class IIb bacteriocin, lactobin A/cerein 7B family -
  SGGBAA2069_RS10105 (SGGBAA2069_c19800) - 2026278..2026529 (-) 252 WP_009855010.1 bacteriocin class II family protein -
  SGGBAA2069_RS10110 (SGGBAA2069_c19820) - 2026776..2027033 (+) 258 WP_009855011.1 hypothetical protein -

Sequence

Protein


Download         Length: 243 a.a.        Molecular weight: 28432.53 Da        Isoelectric Point: 5.4409

>NTDB_id=40070 SGGBAA2069_RS10065 WP_013643488.1 2021332..2022063(-) (comE/comE1) [Streptococcus gallolyticus subsp. gallolyticus ATCC BAA-2069]
MLDIYVLEDNIIQQFRMEREIATIMAKNNWDYQRIEVFSSANEIIAKATEKGEHQIFFLDLEIRDDEKQGIDVAKAIREK
DATAIIVFVTTHSEFMLLTYQALVGAIDFIDKNLNDQAFSERIELCLKEAMKHQNDNFGENSFLFETPKARVRVLYSDIL
YFETSPAVHRVILHTKNERVEFYATIAEIAKSDKRLFKCHRSFIINVDNVVRFDRATRSVYFETGESCLVSRDKIKPLLN
EMR

Nucleotide


Download         Length: 732 bp        

>NTDB_id=40070 SGGBAA2069_RS10065 WP_013643488.1 2021332..2022063(-) (comE/comE1) [Streptococcus gallolyticus subsp. gallolyticus ATCC BAA-2069]
ATGTTAGATATTTATGTACTAGAGGATAATATCATACAGCAATTTCGTATGGAACGCGAGATTGCGACCATTATGGCAAA
AAATAATTGGGACTATCAGAGAATAGAGGTGTTTAGTTCCGCAAATGAGATTATAGCTAAGGCAACTGAAAAAGGGGAGC
ATCAAATTTTCTTTCTTGATTTAGAAATCAGAGACGACGAAAAACAAGGAATTGACGTCGCTAAAGCTATTCGTGAAAAA
GATGCAACAGCTATCATTGTTTTTGTAACAACTCATTCAGAATTTATGCTGCTGACCTACCAAGCGTTAGTAGGGGCAAT
TGATTTTATTGATAAGAACCTAAATGACCAAGCATTTAGTGAACGCATAGAGTTGTGCCTAAAGGAAGCCATGAAACATC
AAAATGATAATTTCGGCGAAAATTCCTTTTTATTTGAAACTCCTAAAGCACGTGTGCGCGTTCTATATAGTGATATTCTT
TATTTCGAAACATCTCCTGCCGTGCACCGCGTGATTTTGCATACGAAAAATGAAAGAGTGGAATTTTATGCGACGATTGC
AGAGATTGCTAAATCAGACAAACGTCTTTTCAAGTGTCACCGTTCTTTTATCATTAATGTGGATAATGTGGTTAGATTTG
ATAGAGCGACACGAAGTGTTTATTTCGAAACTGGGGAGTCTTGCTTAGTTTCGAGGGATAAAATAAAACCTCTATTAAAT
GAGATGAGGTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(11-123)

LytTr DNA-binding domain (LytTR)

(152-238)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A1H9V500

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/comE1 Streptococcus equinus JB1

72.016

100

0.72
  comE/blpR Streptococcus mutans UA159

49.372

98.354

0.486
  comE/comE2 Streptococcus equinus JB1

46.281

99.588

0.461

Multiple sequence alignment