Detailed information NTG0400478

Bioinformatically predicted

Overview

• Name: pknB
• Type: Regulator
• Locus tag: GJS32_RS08220
• Genome accession: NZ_CP046040
• Coordinates: 1734554..1736449 (-)
• Length: 631 a.a.
• NCBI ID: WP_138119682.1
• Uniprot ID: -
• Organism: Streptococcus equi subsp. zooepidemicus strain OH-71905
• Function: modulate the activity of ComDE; modulate the activity of VicKR (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IS/Tn	1733200..1734459	1734554..1736449	flank	95

Gene organization within MGE regions

Location: 1733200..1736449

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GJS32_RS08215 (GJS32_08215)	-	1733200..1734459 (+)	1260	WP_014622390.1	ISL3-like element ISSeq1 family transposase	-
GJS32_RS08220 (GJS32_08220)	pknB	1734554..1736449 (-)	1896	WP_138119682.1	Stk1 family PASTA domain-containing Ser/Thr kinase	Regulator

Sequence

Protein

• Length: 631 a.a.
• Molecular weight: 68527.69 Da
• Isoelectric Point: 6.6073

>NTDB_id=400478 GJS32_RS08220 WP_138119682.1 1734554..1736449(-) (pknB) [Streptococcus equi subsp. zooepidemicus strain OH-71905]
MIQIGKLFAGRYRILKSIGRGGMADVYLANDLILDNEDVAIKVLRTNYQTDQVAVARFQREARAMAELNHPNIVAIRDIG
EEDGQQFLVMEYVDGSDLKKYIQDHAPLSNNEVVRIMEEVLSAMTLAHQKGIVHRDLKPQNILLTKSGVVKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATIQSDIYAMGIMLFEMLTGHIPYDGDSAVTIALQHFQKPLPSIIDENPNVP
QALENVVIRATAKKLSDRYRSTFEMSRDLMTALSYNRSRERKVIFDDVESTKPLPKVTPAPITAPKVSAASQASGAADTR
PEQTSQMDTLQKPQKKKKNGRFLGTLLKILFSFFVVGVALFAYLVLTKPTTVKVPDVTGSSLNAAKQVLEEAGLKVGKVH
QIESDTVSEDQVVKTNPQAGSAKRKGSSVDLYLSIGNKGFEMENYKGQDYQDVMTSLTETYGVPKSKIKIERIVTNEYPE
NTVISQSPSAGEKFNPAGKSKITLSVAVGDTVIMPMVTEYSYADAVNTLTALGIDAARIKAYTPSSSSPTGFVQVSSPSS
KAIVSGQTPYYGTQISLSEKGDISLYLYPEETRASSSSSSSDTSASNPSAGDTTDSSSHTELGQNDAVITP

Nucleotide

• Length: 1896 bp

>NTDB_id=400478 GJS32_RS08220 WP_138119682.1 1734554..1736449(-) (pknB) [Streptococcus equi subsp. zooepidemicus strain OH-71905]
ATGATTCAGATTGGCAAGCTATTTGCTGGTCGTTATCGCATTCTAAAATCTATAGGCCGCGGTGGTATGGCGGATGTTTA
TTTAGCAAACGATTTGATTCTGGATAATGAGGACGTTGCCATTAAGGTCTTGCGGACCAATTATCAAACAGATCAGGTTG
CTGTTGCGCGTTTTCAAAGAGAAGCGCGAGCCATGGCTGAATTAAATCACCCCAATATTGTTGCCATTCGGGATATAGGC
GAGGAAGACGGACAGCAATTTTTAGTAATGGAATATGTTGATGGCTCTGATTTGAAAAAATACATTCAGGATCATGCGCC
ATTATCTAACAATGAGGTGGTGAGAATCATGGAAGAGGTTCTTTCTGCCATGACTCTGGCCCACCAAAAAGGAATTGTTC
ACAGGGATTTAAAGCCTCAAAACATTCTTTTGACCAAATCAGGTGTTGTTAAGGTTACAGATTTTGGGATTGCCGTTGCC
TTTGCAGAGACCAGTCTAACCCAGACAAATTCTATGCTAGGAAGTGTGCATTACCTCTCACCTGAGCAAGCGCGTGGTTC
TAAAGCGACAATTCAAAGTGATATTTACGCGATGGGAATCATGCTCTTTGAAATGCTAACAGGGCATATTCCTTATGATG
GCGATAGCGCTGTGACGATTGCTCTGCAGCATTTTCAAAAGCCGCTGCCCTCTATCATTGATGAAAATCCTAATGTGCCT
CAAGCCTTGGAAAACGTTGTTATTCGGGCCACTGCCAAAAAGCTAAGTGACCGTTATCGCTCGACCTTTGAGATGAGCAG
GGATTTGATGACAGCCCTTAGCTATAACCGCAGTCGTGAGCGTAAGGTTATTTTTGATGATGTCGAAAGCACAAAGCCAT
TACCAAAGGTCACACCAGCCCCTATCACAGCACCTAAGGTGTCGGCTGCCAGTCAGGCATCTGGAGCAGCTGATACTAGA
CCTGAGCAGACTAGCCAGATGGACACCCTGCAAAAGCCTCAAAAAAAGAAAAAAAATGGGCGCTTTTTAGGAACGCTCTT
AAAAATCTTATTTTCCTTTTTCGTTGTCGGTGTGGCTCTTTTTGCTTATCTGGTCTTGACCAAGCCAACTACGGTTAAGG
TTCCTGATGTGACAGGCTCTAGTCTCAATGCTGCCAAGCAGGTCTTGGAGGAGGCAGGACTAAAGGTCGGTAAGGTCCAT
CAGATTGAAAGCGACACAGTCAGTGAGGATCAGGTGGTTAAGACAAATCCTCAAGCTGGCTCAGCTAAGCGAAAAGGCTC
CAGCGTTGACCTTTACCTTTCGATCGGAAATAAAGGCTTTGAGATGGAAAATTATAAGGGACAGGATTATCAGGATGTGA
TGACCAGTCTGACTGAGACCTACGGTGTACCAAAGTCAAAAATCAAGATTGAGCGTATCGTGACAAATGAATACCCTGAA
AACACCGTTATTAGCCAGTCACCAAGCGCGGGAGAAAAATTTAACCCAGCTGGTAAATCCAAGATTACGCTTAGTGTAGC
AGTGGGTGATACGGTCATCATGCCAATGGTAACTGAGTACAGCTATGCAGATGCGGTGAATACACTAACAGCCCTAGGAA
TTGACGCCGCAAGGATCAAGGCCTACACTCCAAGCTCAAGCTCTCCGACGGGCTTTGTTCAGGTGAGCTCCCCAAGCTCA
AAGGCGATTGTCAGTGGGCAGACACCGTATTATGGTACCCAGATTAGCCTTTCTGAAAAGGGTGATATTAGCCTCTACCT
CTACCCTGAGGAGACACGTGCATCAAGCAGCTCATCGAGCTCTGATACCTCAGCTTCTAATCCATCAGCTGGAGATACAA
CAGACTCAAGCAGTCATACCGAATTAGGTCAAAATGACGCTGTTATAACACCGTAA

Domains

Predicted by InterproScan.

• Protein kinase domain (Pkinase) (12-232)

• PASTA domain (PASTA) (372-434)

• PASTA domain (PASTA) (441-506)

• PASTA domain (PASTA) (512-588)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
pknB	Streptococcus mutans UA159	65.546	94.295	0.618
stkP/pknB	Streptococcus salivarius strain HSISS4	62.415	93.185	0.582
stkP	Streptococcus pneumoniae TIGR4	59.302	81.775	0.485
stkP	Streptococcus pneumoniae D39	58.915	81.775	0.482
stkP	Streptococcus pneumoniae R6	58.915	81.775	0.482
stkP	Streptococcus pneumoniae Rx1	58.721	81.775	0.48