Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   GJE16_RS02455 Genome accession   NZ_CP045931
Coordinates   470254..470946 (+) Length   230 a.a.
NCBI ID   WP_223716556.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain AUSMDU00010538     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 465254..475946
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  GJE16_RS02425 (GJE16_02425) - 466541..466828 (-) 288 WP_000777753.1 hypothetical protein -
  GJE16_RS02430 (GJE16_02430) - 466838..467248 (-) 411 WP_001278301.1 HIT family protein -
  GJE16_RS02435 (GJE16_02435) pptA 467316..468047 (+) 732 WP_000889921.1 ABC transporter ATP-binding protein Regulator
  GJE16_RS02440 (GJE16_02440) - 468044..469093 (+) 1050 WP_000653771.1 ABC transporter permease -
  GJE16_RS02445 (GJE16_02445) - 469261..469590 (-) 330 WP_000132572.1 hypothetical protein -
  GJE16_RS02450 (GJE16_02450) - 469866..470204 (+) 339 WP_000876675.1 LytTR family DNA-binding domain-containing protein -
  GJE16_RS02455 (GJE16_02455) comE/blpR 470254..470946 (+) 693 WP_223716556.1 response regulator transcription factor Regulator
  GJE16_RS02460 (GJE16_02460) - 470960..472300 (+) 1341 WP_050073044.1 sensor histidine kinase -
  GJE16_RS02465 (GJE16_02465) blpC 472371..472499 (-) 129 WP_000358815.1 quorum-sensing system pheromone BlpC -
  GJE16_RS02470 (GJE16_02470) - 472556..473917 (-) 1362 WP_001069060.1 bacteriocin secretion accessory protein -
  GJE16_RS02475 (GJE16_02475) comA/nlmT 473928..475604 (-) 1677 WP_196300924.1 peptide cleavage/export ABC transporter Regulator

Sequence

Protein


Download         Length: 230 a.a.        Molecular weight: 26905.90 Da        Isoelectric Point: 6.7684

>NTDB_id=399394 GJE16_RS02455 WP_223716556.1 470254..470946(+) (comE/blpR) [Streptococcus pneumoniae strain AUSMDU00010538]
METTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRDPYALIVFVTTHSEFM
PLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYYLETSPRAHRVILYTK
TDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEAINKLH

Nucleotide


Download         Length: 693 bp        

>NTDB_id=399394 GJE16_RS02455 WP_223716556.1 470254..470946(+) (comE/blpR) [Streptococcus pneumoniae strain AUSMDU00010538]
ATTGAAACGACGATTGAGAAACTTTTGAAAGCACATCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCA
ACTGCTGGCTGAAGTGCATGAGAAGGGGGCCCATCAGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGG
GACTGGAAGTGGCTAGAAAGATTCGGGATCGGGATCCTTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATG
CCCCTGTCTTTTCGCTACCAAGTGTCTGCTTTGGACTACATTGATAAGGCCTTGTCAGCAGAGGAGTTTGAATCTCGGAT
CGAGACAGCCCTCCTCTATGCCAATAGTCAAGATAGTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTG
CCCAATTTCAGTATCCTTTTAAAGAGGTTTACTATCTCGAAACGTCGCCCAGAGCCCATCGTGTTATTCTCTATACCAAG
ACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGAGGTTTTCAAGCAGGAGCCCCGTCTCTTGCAGTGCCACCGCTCTTT
TCTCATCAATCCTGCAAATGTGGTGCATTTGGATAAGAAAGAAAAACTGCTTTTCTTTCCCAATGGTGGAAGTTGTCTAA
TCGCCCGTTATAAGGTCAGGGAAGTGTCTGAGGCCATCAATAAATTACACTGA

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(136-226)

Response regulator receiver domain (Response_reg)

(17-107)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

53.07

99.13

0.526
  comE/comE1 Streptococcus equinus JB1

42.342

96.522

0.409
  comE/comE2 Streptococcus equinus JB1

36.245

99.565

0.361
  comE Streptococcus infantis strain Atu-4

35.622

100

0.361

Multiple sequence alignment