Detailed information    

insolico Bioinformatically predicted

Overview

Name   comB   Type   Regulator
Locus tag   STH8232_RS08360 Genome accession   NC_017581
Coordinates   1612278..1613645 (-) Length   455 a.a.
NCBI ID   WP_011681574.1    Uniprot ID   -
Organism   Streptococcus thermophilus JIM 8232     
Function   transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 1607278..1618645
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  STH8232_RS12265 (STH8232_1931) - 1607375..1607776 (-) 402 WP_011226490.1 hypothetical protein -
  STH8232_RS11435 (STH8232_1934) - 1608631..1608774 (-) 144 WP_014608661.1 hypothetical protein -
  STH8232_RS08330 (STH8232_1935) - 1608781..1609011 (-) 231 WP_014608662.1 bacteriocin class II family protein -
  STH8232_RS08335 (STH8232_1936) - 1609367..1609567 (-) 201 WP_011681569.1 hypothetical protein -
  STH8232_RS08340 (STH8232_1937) - 1609586..1609762 (-) 177 WP_011681570.1 Blp family class II bacteriocin -
  STH8232_RS08345 (STH8232_1938) - 1610013..1610750 (+) 738 WP_011681571.1 LytR/AlgR family response regulator transcription factor -
  STH8232_RS11985 comD/blpH 1611281..1612084 (+) 804 WP_223899638.1 ATP-binding protein Regulator
  STH8232_RS08355 (STH8232_1940) - 1612102..1612263 (-) 162 WP_011681573.1 ComC/BlpC family leader-containing pheromone/bacteriocin -
  STH8232_RS08360 (STH8232_1941) comB 1612278..1613645 (-) 1368 WP_011681574.1 bacteriocin secretion accessory protein Regulator
  STH8232_RS08365 (STH8232_1942) - 1613661..1615815 (-) 2155 Protein_1573 peptide cleavage/export ABC transporter -
  STH8232_RS08370 (STH8232_1946) - 1616829..1618574 (-) 1746 WP_014621922.1 ABC transporter ATP-binding protein -

Sequence

Protein


Download         Length: 455 a.a.        Molecular weight: 50382.07 Da        Isoelectric Point: 4.7492

>NTDB_id=39678 STH8232_RS08360 WP_011681574.1 1612278..1613645(-) (comB) [Streptococcus thermophilus JIM 8232]
MNPQLFKSTEFYHRRYHNMSTVLITPLILLVIFLFLFAFFAKKEVTVTSRGSIEPTKVIAVIQSTSDNTIIDNQLVANKV
VKKGDTLVQYSETMEASQKEGLQKQLELLKRQESGLKTLQSSLTQGTNLFQEQEDEFGYQSTFNTYLSQAQDIDLGVAKT
NTEVNNQAAIASNTGSAIDNQISQLQTQVSEYEALSQAITNHETTLPEGNPHQATLNAYNSQYATTPDASVTDQYLSQVN
TNISSLNASIGNLEIQKAGTGTVVTYDNSDSTKKEALKNQFLQNAGQQLSSVETQINDTESKINQADVLLTNTLIQSPED
GILHLSQADKKATMAATGTELAQLYPDMTQTQEVAITYYVNSDYVPKLQKGQSVRLTLDKVGNHGTTIIGKLESIDNSAT
ETERGNVFRVTARASISEKEAQNLRYGLEGRVTSVIDQKTYFNYFKDKLLNLQDQ

Nucleotide


Download         Length: 1368 bp        

>NTDB_id=39678 STH8232_RS08360 WP_011681574.1 1612278..1613645(-) (comB) [Streptococcus thermophilus JIM 8232]
ATGAATCCACAGTTGTTTAAAAGCACAGAGTTTTACCATCGTCGCTACCACAATATGTCTACTGTTTTGATTACTCCCTT
GATTTTGTTAGTTATTTTCCTTTTTCTTTTCGCTTTTTTTGCTAAGAAGGAAGTTACAGTCACGTCTAGAGGAAGTATAG
AGCCAACCAAGGTTATCGCAGTAATCCAATCAACCAGTGACAATACCATCATAGATAATCAACTGGTTGCTAATAAGGTT
GTTAAAAAAGGGGACACCTTAGTTCAGTATTCAGAGACCATGGAGGCATCGCAAAAAGAGGGGCTTCAAAAGCAACTAGA
ACTTTTAAAAAGACAGGAATCAGGTTTGAAGACCTTGCAATCTAGCCTAACGCAGGGAACCAATCTTTTCCAAGAACAGG
AAGACGAGTTTGGTTATCAGAGTACTTTTAACACCTACCTAAGTCAGGCACAGGATATTGACTTGGGTGTGGCTAAAACA
AATACAGAGGTTAATAACCAAGCAGCAATTGCGAGTAATACCGGTTCTGCTATTGATAACCAGATTAGTCAATTGCAGAC
TCAGGTCTCAGAGTATGAGGCGCTCTCTCAAGCTATTACCAATCATGAAACAACTTTACCTGAAGGCAATCCTCATCAGG
CAACCTTAAATGCCTATAACAGTCAGTATGCTACGACACCGGATGCCAGTGTAACAGACCAATACCTATCTCAAGTTAAT
ACCAATATTTCGAGCTTGAATGCTTCCATAGGTAATCTAGAAATCCAAAAGGCTGGGACAGGCACAGTTGTAACTTATGA
CAATAGTGATAGCACTAAAAAAGAAGCTCTAAAAAATCAATTCTTGCAAAATGCAGGACAGCAATTGAGCTCAGTGGAAA
CACAAATTAACGATACCGAGAGTAAAATCAATCAGGCAGATGTCCTTCTGACTAATACCCTCATCCAGTCACCAGAAGAT
GGAATCTTACACTTGAGTCAAGCTGATAAAAAAGCAACCATGGCTGCGACAGGAACTGAGTTGGCCCAGCTTTATCCCGA
TATGACTCAAACCCAGGAAGTTGCCATTACTTATTATGTGAATTCGGATTATGTGCCAAAACTGCAAAAAGGCCAGTCAG
TTCGACTGACCTTGGATAAGGTTGGTAATCACGGTACCACAATTATTGGAAAACTTGAGAGTATTGATAATTCTGCCACG
GAAACAGAAAGGGGGAATGTGTTTAGAGTAACTGCTAGGGCAAGTATTTCAGAAAAAGAAGCCCAAAATCTACGTTACGG
TCTAGAAGGTCGTGTGACAAGCGTTATTGACCAAAAGACCTACTTCAATTACTTTAAAGACAAGTTACTAAACTTGCAAG
ACCAATAG

Domains

Predicted by InterProScan.

HlyD family secretion protein ()

(315-427)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comB Streptococcus pneumoniae Rx1

39.468

99.121

0.391
  comB Streptococcus pneumoniae D39

39.468

99.121

0.391
  comB Streptococcus pneumoniae R6

39.468

99.121

0.391
  comB Streptococcus pneumoniae TIGR4

38.803

99.121

0.385
  comB Streptococcus mitis SK321

38.137

99.121

0.378
  comB Streptococcus mitis NCTC 12261

38.137

99.121

0.378

Multiple sequence alignment