Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   GFB63_RS06215 Genome accession   NZ_CP045596
Coordinates   1208347..1209036 (+) Length   229 a.a.
NCBI ID   WP_084828484.1    Uniprot ID   A0A0E2Q3Q9
Organism   Streptococcus thermophilus strain TK-P3A     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1203347..1214036
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  GFB63_RS10625 (GFB63_06375) - 1204313..1204483 (+) 171 Protein_1186 ascorbate 6-phosphate lactonase -
  GFB63_RS06195 (GFB63_06380) - 1204500..1205171 (-) 672 WP_064355629.1 TrkA family potassium uptake protein -
  GFB63_RS06200 (GFB63_06385) - 1205211..1206575 (-) 1365 WP_081247984.1 TrkH family potassium uptake protein -
  GFB63_RS06205 (GFB63_06390) rsmG 1206645..1207358 (-) 714 WP_064355625.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  GFB63_RS06210 (GFB63_06395) - 1207655..1208191 (+) 537 WP_084828483.1 DUF177 domain-containing protein -
  GFB63_RS06215 (GFB63_06400) covR 1208347..1209036 (+) 690 WP_084828484.1 response regulator transcription factor Regulator
  GFB63_RS06220 (GFB63_06405) covS 1209033..1210550 (+) 1518 WP_084828485.1 HAMP domain-containing histidine kinase Regulator
  GFB63_RS06225 (GFB63_06410) nrdR 1210673..1211152 (+) 480 WP_002949642.1 transcriptional regulator NrdR -
  GFB63_RS06230 (GFB63_06415) - 1211149..1212324 (+) 1176 WP_100262514.1 DnaD domain protein -
  GFB63_RS06235 (GFB63_06420) dnaI 1212328..1213230 (+) 903 WP_084828487.1 primosomal protein DnaI -

Sequence

Protein


Download         Length: 229 a.a.        Molecular weight: 26683.82 Da        Isoelectric Point: 4.7059

>NTDB_id=395481 GFB63_RS06215 WP_084828484.1 1208347..1209036(+) (covR) [Streptococcus thermophilus strain TK-P3A]
MSKRILIVEDERNLARFVSLELQHEGYDVVTADNGREGLEMALEKDFDLILLDLMLPEMDGFEVTRRLQQEKDTYIMMMT
ARDSIMDIVAGLDRGADDYIIKPFAIEELLARIRATFRRQDIEATKKVPAKASTYRDLKLDVQNRAVVRGDEVIPLTKRE
FDLLNTLLSNMNQVMTREELLLQVWKYDDVIETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIRER

Nucleotide


Download         Length: 690 bp        

>NTDB_id=395481 GFB63_RS06215 WP_084828484.1 1208347..1209036(+) (covR) [Streptococcus thermophilus strain TK-P3A]
ATGAGCAAACGCATTTTGATTGTTGAAGATGAGAGAAACCTTGCTCGTTTTGTCTCTCTTGAACTTCAACACGAAGGATA
CGACGTTGTGACAGCGGACAACGGACGCGAAGGACTTGAAATGGCACTTGAGAAAGATTTCGATCTGATTCTCTTGGACC
TTATGTTGCCTGAGATGGACGGTTTCGAAGTGACACGTCGTCTCCAACAAGAAAAAGATACTTATATTATGATGATGACA
GCTCGCGACTCAATCATGGATATTGTTGCTGGTTTGGATCGTGGAGCTGATGACTATATTATAAAACCATTTGCGATTGA
AGAACTGTTGGCACGTATTCGTGCAACCTTCCGTCGTCAAGATATCGAAGCTACTAAGAAGGTACCAGCTAAAGCGTCAA
CCTATCGCGATTTAAAATTGGATGTTCAAAACCGTGCAGTTGTTCGCGGTGATGAGGTAATTCCATTGACAAAACGTGAG
TTTGATTTGTTGAACACACTTTTAAGCAATATGAACCAAGTAATGACCCGTGAGGAACTCTTGCTTCAAGTCTGGAAATA
TGATGACGTAATTGAAACAAACGTTGTAGATGTTTATATTCGTTACTTACGTGGGAAAATCGACATTCCAGGTAAGGAAT
CATACATTCAAACAGTACGAGGGATGGGTTACGTTATCCGTGAAAGATGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(152-225)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0E2Q3Q9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

95.633

100

0.956
  covR Lactococcus lactis subsp. lactis strain DGCC12653

67.544

99.563

0.672
  vicR Streptococcus mutans UA159

44.828

100

0.454
  micA Streptococcus pneumoniae Cp1015

42.083

100

0.441

Multiple sequence alignment