Detailed information NTG0395482

Bioinformatically predicted

Overview

• Name: covS
• Type: Regulator
• Locus tag: GFB63_RS06220
• Genome accession: NZ_CP045596
• Coordinates: 1209033..1210550 (+)
• Length: 505 a.a.
• NCBI ID: WP_084828485.1
• Uniprot ID: A0A0E2Q5R4
• Organism: Streptococcus thermophilus strain TK-P3A
• Function: repress comR expression (predicted from homology) Competence regulation

Genomic Context

Location: 1204033..1215550

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GFB63_RS10625 (GFB63_06375)	-	1204313..1204483 (+)	171	Protein_1186	ascorbate 6-phosphate lactonase	-
GFB63_RS06195 (GFB63_06380)	-	1204500..1205171 (-)	672	WP_064355629.1	TrkA family potassium uptake protein	-
GFB63_RS06200 (GFB63_06385)	-	1205211..1206575 (-)	1365	WP_081247984.1	TrkH family potassium uptake protein	-
GFB63_RS06205 (GFB63_06390)	rsmG	1206645..1207358 (-)	714	WP_064355625.1	16S rRNA (guanine(527)-N(7))-methyltransferase RsmG	-
GFB63_RS06210 (GFB63_06395)	-	1207655..1208191 (+)	537	WP_084828483.1	DUF177 domain-containing protein	-
GFB63_RS06215 (GFB63_06400)	covR	1208347..1209036 (+)	690	WP_084828484.1	response regulator transcription factor	Regulator
GFB63_RS06220 (GFB63_06405)	covS	1209033..1210550 (+)	1518	WP_084828485.1	HAMP domain-containing histidine kinase	Regulator
GFB63_RS06225 (GFB63_06410)	nrdR	1210673..1211152 (+)	480	WP_002949642.1	transcriptional regulator NrdR	-
GFB63_RS06230 (GFB63_06415)	-	1211149..1212324 (+)	1176	WP_100262514.1	DnaD domain protein	-
GFB63_RS06235 (GFB63_06420)	dnaI	1212328..1213230 (+)	903	WP_084828487.1	primosomal protein DnaI	-
GFB63_RS06240 (GFB63_06425)	der	1213336..1214646 (+)	1311	WP_084828488.1	ribosome biogenesis GTPase Der	-
GFB63_RS06245	-	1214710..1215378 (+)	669	Protein_1197	HI_0552 family protein	-

Sequence

Protein

• Length: 505 a.a.
• Molecular weight: 57568.03 Da
• Isoelectric Point: 5.5179

>NTDB_id=395482 GFB63_RS06220 WP_084828485.1 1209033..1210550(+) (covS) [Streptococcus thermophilus strain TK-P3A]
MSKLFGKVTIRKKLTMTTAVVFFLVLSMFTLVVVFSANTLLLQRERQNVNNTISKVVTYIEKDWDSDEELSPEPLLAAFY
SPKNIYPSIINGVLSEKRSLDGQVAVSNRLYSNQSVYVYDKKGTFIFTSEEDTDSPPGMSEVNKLKLVSYKGKRGFLLQV
PIYGKDKKTIVGYAQVFHDLKFYYALKERLIFLLIFLEVGMTVLVIAVIVVVLTSILRPMRQLHETMGIIIDSPSDLELR
SKIESHDEIGALALNFNCMMDKIQENNQMQMRFLSDVSHELRTPIAVIKGHMDLLQRWGKNDPEILEESLEAASHEANRM
TIMINDMLDSIRVKGSFDNHRNDTCDLNSSIRTVIGNFRVLHDDYQFYLNDSEGSDRPAQIYSQHFEQVITILIDNAVKY
SPVNKKIQVTIKALEDEMLVQVQDNGEGISKEDIEHIFERFYRSDKARNRTTTQSGVGIGLSILYQIVEAYRCHIDVSSE
LGVGTRFDLYIPFAESETTTPQIEG

Nucleotide

• Length: 1518 bp

>NTDB_id=395482 GFB63_RS06220 WP_084828485.1 1209033..1210550(+) (covS) [Streptococcus thermophilus strain TK-P3A]
ATGAGTAAATTATTTGGTAAAGTAACCATTAGAAAAAAGTTGACCATGACAACTGCTGTGGTCTTCTTTCTTGTATTGTC
GATGTTCACTCTGGTTGTTGTATTTTCAGCCAATACGCTTCTTTTGCAACGTGAACGTCAAAATGTAAATAATACAATCT
CAAAAGTTGTTACTTATATCGAAAAGGACTGGGACTCTGATGAAGAGTTGAGTCCAGAGCCGCTTTTAGCGGCCTTTTAT
TCACCGAAAAATATCTATCCATCAATCATTAATGGAGTGCTTTCTGAAAAGCGTTCCTTAGATGGTCAAGTTGCGGTTTC
TAATAGATTATATTCCAACCAGTCTGTCTATGTTTATGACAAAAAGGGAACTTTTATCTTTACTTCTGAGGAGGATACAG
ACTCACCTCCAGGCATGTCTGAGGTCAATAAACTGAAGTTGGTTTCCTATAAAGGTAAACGTGGTTTCTTACTACAAGTT
CCAATCTATGGCAAGGATAAGAAGACCATTGTTGGGTATGCTCAAGTTTTCCATGATTTGAAATTCTACTATGCGTTAAA
AGAGCGTTTAATTTTCCTATTGATATTCCTTGAAGTAGGAATGACGGTCTTAGTTATTGCAGTAATTGTAGTTGTCTTGA
CATCTATTCTTCGTCCGATGAGGCAGTTACACGAAACAATGGGTATTATTATCGATTCGCCAAGTGATTTGGAGCTTCGA
TCTAAGATTGAGAGTCATGATGAGATTGGTGCTTTGGCACTTAACTTTAACTGTATGATGGATAAAATTCAAGAAAATAA
TCAGATGCAGATGCGTTTCTTGAGTGACGTCAGTCACGAATTACGTACTCCCATTGCAGTTATTAAAGGACATATGGACC
TCTTGCAACGTTGGGGTAAAAATGATCCTGAAATCCTTGAAGAAAGTCTTGAAGCTGCAAGTCACGAAGCCAACCGTATG
ACGATTATGATTAACGATATGTTGGATTCTATTCGTGTTAAAGGGTCATTTGACAATCATAGAAATGATACATGTGATTT
GAATTCTTCAATCCGTACGGTTATTGGGAATTTCCGTGTCCTACATGACGACTACCAATTCTACCTCAATGATTCTGAGG
GTTCAGATCGTCCAGCACAGATTTACAGCCAGCACTTTGAACAGGTTATTACTATTTTGATTGATAATGCGGTCAAGTAT
TCGCCTGTTAATAAGAAAATCCAGGTTACTATCAAGGCTCTGGAAGATGAGATGCTGGTACAGGTACAGGATAATGGTGA
GGGTATCTCTAAAGAAGATATTGAACATATATTTGAACGCTTCTATCGTTCAGATAAGGCGCGTAATCGTACGACAACCC
AATCTGGTGTGGGTATTGGTTTATCAATCCTCTATCAAATTGTGGAAGCTTATCGATGCCATATCGATGTCAGTTCAGAA
CTTGGTGTGGGTACACGTTTTGACCTCTACATTCCTTTTGCAGAGTCAGAAACTACGACACCTCAAATTGAAGGTTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (384-494)

• His Kinase A (phospho-acceptor) domain (HisKA) (270-329)

• ArlS sensor domain (ArlS_N) (39-187)

• HAMP domain (HAMP) (213-265)

3D structure

• AlphaFold DB: A0A0E2Q5R4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
covS	Streptococcus salivarius strain HSISS4	94.223	99.406	0.937