Detailed information NTG0395245

Bioinformatically predicted

Overview

• Name: comA
• Type: Regulator
• Locus tag: GFB64_RS11830
• Genome accession: NZ_CP045567
• Coordinates: 2455367..2457559 (-)
• Length: 730 a.a.
• NCBI ID: WP_194853557.1
• Uniprot ID: -
• Organism: Lacticaseibacillus paracasei strain TK-P4A
• Function: processing and transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 2450367..2462559

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GFB64_RS11800 (GFB64_12620)	-	2450533..2450817 (-)	285	WP_019881096.1	bacteriocin immunity protein	-
GFB64_RS11805 (GFB64_12625)	-	2451010..2451306 (-)	297	WP_003596056.1	bacteriocin immunity protein	-
GFB64_RS11810 (GFB64_12630)	-	2451408..2452763 (-)	1356	WP_003567335.1	threonine/serine exporter ThrE family protein	-
GFB64_RS11815 (GFB64_12635)	-	2453069..2453380 (-)	312	WP_003580849.1	hypothetical protein	-
GFB64_RS11820 (GFB64_12640)	-	2453453..2453803 (-)	351	WP_194853555.1	hypothetical protein	-
GFB64_RS11825 (GFB64_12645)	-	2453977..2455356 (-)	1380	WP_194853556.1	bacteriocin secretion accessory protein	-
GFB64_RS11830 (GFB64_12650)	comA	2455367..2457559 (-)	2193	WP_194853557.1	peptide cleavage/export ABC transporter	Regulator
GFB64_RS11835 (GFB64_12655)	-	2458024..2458161 (-)	138	WP_003571414.1	bacteriocin-like peptide, LSEI_2386 family	-
GFB64_RS11840 (GFB64_12660)	-	2458530..2459648 (+)	1119	WP_016365086.1	GHKL domain-containing protein	-
GFB64_RS11845 (GFB64_12665)	-	2459653..2460459 (+)	807	WP_003567351.1	LytR/AlgR family response regulator transcription factor	-
GFB64_RS11850 (GFB64_12670)	-	2460821..2461018 (-)	198	WP_003661762.1	hypothetical protein	-
GFB64_RS11855 (GFB64_12675)	-	2461565..2461804 (+)	240	WP_003588828.1	hypothetical protein	-
GFB64_RS11860 (GFB64_12680)	-	2462064..2462237 (-)	174	WP_032675994.1	bacteriocin	-
GFB64_RS11865 (GFB64_12685)	-	2462272..2462460 (-)	189	WP_003567358.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-

Sequence

Protein

• Length: 730 a.a.
• Molecular weight: 81318.56 Da
• Isoelectric Point: 7.0227

>NTDB_id=395245 GFB64_RS11830 WP_194853557.1 2455367..2457559(-) (comA) [Lacticaseibacillus paracasei strain TK-P4A]
MIKYNLKLGQAQYYKRYYTPQVDERDCGVAALNMLLQFNGSDYSLAHLRQLAKTDQEGTTALGIVRAAQALHFETKAVKA
DMTLFDLDDVPYPFLVHVLKRGELLHYYVVFKATKDHILIGDPDSSVAMTWLPKERFAKEWSGVAIFIAPEPQYQPRKED
KGSLFAFVPMLARQKGIIANIIVAAVLITLISIVGSYFLQSIIDTYIPNVMRTTLGMIASGLILAYVLQSVLTYGQNFLM
AVLGQRLSIDVILGYVRHLYELPMSFFSTRRTGEIVSRFSDANKIIDALANTIMTLFLDIWIVLILGIVLGIQNTTLFLV
SLIAVPCYLVIVFAFQRPFNRLNQETMESNAILSSSIIEDLNGIETIKSLTGEKVSYERVDREFVTYLKKSFNYTKADQL
QQAIKGLLKLVLNVVVLWIGASLVMANKMSLGQMLTFNALLAYFTNPLESIVNLQPKLQMAKVANNRLNEVYLVESEFKE
QRSLNDRHLIDGAINVTDVSFKYGFGQDVLKQINLEIPENAKYTIVGMSGSGKSTLAKLLVGFYPVDTGKGKITFNGVPI
SDVDLTTLRQYIEYVPQDPFIFSGSVIENLTLGSRSNITEADIEAACSVAEIAGDISNLPQIWQTKLSESGSILSGGQKQ
RLAIARALLSPAKVLIFDESTSSLDTITERKIVDRLLAMTDRTIIFVAHRLTIAAKTEQIVVMDHGAIVEQGNHAELLAK
QGYYARLVSE

Nucleotide

• Length: 2193 bp

>NTDB_id=395245 GFB64_RS11830 WP_194853557.1 2455367..2457559(-) (comA) [Lacticaseibacillus paracasei strain TK-P4A]
ATGATCAAATACAACCTAAAGCTCGGCCAAGCACAGTATTACAAGCGTTACTACACGCCTCAGGTGGATGAGCGCGATTG
CGGGGTTGCGGCGCTTAATATGCTGCTGCAATTTAATGGCTCGGATTATTCGCTAGCGCATCTGCGACAATTGGCGAAGA
CGGATCAGGAAGGAACAACAGCGTTAGGGATTGTCCGAGCTGCTCAGGCACTTCATTTTGAAACCAAGGCTGTCAAGGCG
GATATGACGTTGTTTGATCTTGATGATGTTCCTTATCCGTTTCTTGTCCATGTTTTGAAGCGTGGCGAGTTGCTTCATTA
TTATGTGGTGTTTAAGGCGACAAAGGATCATATCTTGATTGGCGATCCTGATTCATCAGTAGCGATGACCTGGCTTCCCA
AAGAGCGCTTTGCGAAGGAGTGGTCGGGGGTCGCTATTTTTATTGCGCCAGAACCGCAATATCAACCACGCAAAGAGGAC
AAAGGCAGTCTCTTTGCGTTTGTGCCGATGCTAGCGCGACAAAAAGGAATCATTGCCAATATTATTGTCGCCGCTGTGTT
GATCACGTTGATTAGTATTGTCGGGTCTTATTTTCTTCAGTCGATTATTGATACTTATATTCCAAACGTGATGCGCACAA
CTTTGGGAATGATTGCCAGTGGTCTCATCCTCGCTTATGTGCTGCAGTCGGTTTTAACCTATGGGCAAAATTTTTTGATG
GCTGTTTTAGGACAACGTTTGTCGATTGATGTCATTTTGGGTTACGTCAGACACCTTTATGAATTACCTATGTCCTTCTT
TTCCACGCGTCGGACTGGGGAAATTGTGTCGCGGTTTTCCGATGCTAATAAAATTATTGATGCGCTGGCGAACACGATTA
TGACCTTGTTTCTTGATATTTGGATTGTCTTAATTTTAGGGATCGTGTTAGGCATTCAAAACACCACCTTATTCTTGGTG
TCTTTAATTGCTGTGCCTTGTTATTTGGTGATTGTGTTCGCTTTTCAGCGGCCATTTAATCGACTGAATCAAGAGACGAT
GGAAAGCAATGCCATTTTGAGTTCATCTATTATCGAGGATTTGAACGGGATTGAGACGATTAAATCACTGACCGGTGAGA
AAGTCAGTTATGAACGGGTTGACCGTGAATTCGTCACGTATTTGAAAAAGTCGTTCAATTATACAAAAGCTGATCAACTG
CAGCAGGCGATCAAGGGACTGCTGAAGTTGGTTTTGAATGTGGTCGTGCTGTGGATTGGTGCGAGTTTGGTGATGGCTAA
CAAGATGAGTCTAGGACAGATGCTGACGTTCAATGCGTTGTTGGCATATTTCACTAATCCGTTAGAAAGCATCGTTAATT
TGCAACCAAAATTGCAAATGGCCAAAGTCGCGAATAACCGGCTGAATGAAGTGTATTTGGTTGAATCGGAGTTTAAAGAA
CAGCGAAGTTTGAATGATCGGCATTTAATTGATGGCGCCATCAATGTTACCGATGTGTCCTTTAAGTATGGTTTTGGGCA
AGATGTTTTGAAACAAATCAACCTTGAAATCCCGGAGAATGCCAAATACACCATTGTCGGCATGAGCGGATCAGGAAAAT
CGACCTTAGCCAAGTTGCTAGTAGGTTTCTATCCAGTGGACACAGGCAAAGGGAAAATCACATTTAATGGTGTTCCCATC
AGTGATGTTGATCTAACAACGTTACGCCAATACATCGAGTATGTACCGCAAGATCCGTTTATTTTTTCTGGCTCAGTCAT
TGAAAACTTAACGTTGGGTAGCCGTTCGAATATCACTGAAGCCGATATTGAAGCTGCCTGTTCAGTGGCAGAAATTGCCG
GAGATATTTCGAATTTGCCGCAGATATGGCAGACCAAACTTTCTGAAAGCGGCAGTATTTTATCGGGTGGACAAAAGCAG
CGCCTAGCAATTGCCCGCGCGTTATTATCACCGGCAAAAGTGTTGATTTTTGATGAATCGACCAGCAGTTTAGATACGAT
CACCGAGCGAAAAATTGTTGATCGGTTGTTAGCGATGACTGATCGAACCATTATTTTTGTGGCTCATCGGCTGACCATTG
CTGCTAAAACGGAACAGATTGTGGTCATGGATCATGGTGCGATTGTTGAACAAGGAAATCATGCTGAGTTATTGGCCAAA
CAAGGCTATTATGCTCGGTTGGTAAGTGAGTGA

Domains

Predicted by InterproScan.

• Peptidase C39 family (Peptidase_C39) (16-152)

• ABC transporter (ABC_tran) (510-662)

• ABC transporter transmembrane region (ABC_membrane) (180-448)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA	Streptococcus mitis NCTC 12261	58.635	98.356	0.577
comA	Streptococcus pneumoniae Rx1	58.078	98.356	0.571
comA	Streptococcus pneumoniae D39	58.078	98.356	0.571
comA	Streptococcus pneumoniae R6	58.078	98.356	0.571
comA	Streptococcus mitis SK321	57.939	98.356	0.57
comA	Streptococcus pneumoniae TIGR4	57.66	98.356	0.567
comA	Streptococcus gordonii str. Challis substr. CH1	56.825	98.356	0.559
comA/nlmT	Streptococcus mutans UA159	54.709	98.904	0.541