Detailed information
Bioinformatically predicted
Overview
| Name | htrA | Type | Regulator |
| Locus tag | F6447_RS01215 | Genome accession | NZ_CP045012 |
| Coordinates | 240785..242074 (-) | Length | 429 a.a. |
| NCBI ID | WP_002319485.1 | Uniprot ID | - |
| Organism | Enterococcus faecium strain LAC7.2 | ||
| Function | repress competence development (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 223465..294309 | 240785..242074 | within | 0 |
Gene organization within MGE regions
Location: 223465..294309
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| F6447_RS01115 (F6447_01090) | - | 223559..224218 (+) | 660 | WP_002294164.1 | deoxynucleoside kinase | - |
| F6447_RS01120 (F6447_01095) | - | 224303..225208 (+) | 906 | WP_002294163.1 | magnesium transporter CorA family protein | - |
| F6447_RS01125 (F6447_01100) | - | 225210..225842 (-) | 633 | WP_002294161.1 | pentapeptide repeat-containing protein | - |
| F6447_RS01130 (F6447_01105) | infC | 226162..226686 (+) | 525 | WP_002293357.1 | translation initiation factor IF-3 | - |
| F6447_RS01135 (F6447_01110) | rpmI | 226758..226958 (+) | 201 | WP_002289309.1 | 50S ribosomal protein L35 | - |
| F6447_RS01140 (F6447_01115) | rplT | 227011..227370 (+) | 360 | WP_002289310.1 | 50S ribosomal protein L20 | - |
| F6447_RS01145 (F6447_01120) | - | 227622..228959 (+) | 1338 | WP_002289312.1 | hypothetical protein | - |
| F6447_RS01150 (F6447_01125) | - | 229007..231136 (+) | 2130 | WP_002302676.1 | hydantoinase/oxoprolinase family protein | - |
| F6447_RS01155 (F6447_01130) | - | 231111..231800 (+) | 690 | WP_002289315.1 | hypothetical protein | - |
| F6447_RS01160 (F6447_01135) | - | 232208..232894 (-) | 687 | WP_002289316.1 | GntR family transcriptional regulator | - |
| F6447_RS01165 (F6447_01140) | - | 233030..233224 (-) | 195 | WP_002315615.1 | hypothetical protein | - |
| F6447_RS01170 (F6447_01145) | - | 233274..233714 (-) | 441 | WP_002289317.1 | acyl-CoA thioesterase | - |
| F6447_RS01175 (F6447_01150) | - | 233718..234563 (-) | 846 | WP_002289318.1 | NAD(P)H-hydrate dehydratase | - |
| F6447_RS01180 (F6447_01155) | pepV | 234712..236130 (+) | 1419 | WP_002294157.1 | dipeptidase PepV | - |
| F6447_RS01185 (F6447_01160) | - | 236187..237134 (-) | 948 | WP_002289860.1 | glycosyltransferase family 2 protein | - |
| F6447_RS01190 (F6447_01165) | - | 237357..237707 (-) | 351 | WP_002289862.1 | PepSY domain-containing protein | - |
| F6447_RS01195 (F6447_01170) | pepA | 237907..238986 (+) | 1080 | WP_002294156.1 | glutamyl aminopeptidase | - |
| F6447_RS01200 (F6447_01175) | - | 239130..239450 (+) | 321 | WP_002287837.1 | thioredoxin family protein | - |
| F6447_RS01205 (F6447_01180) | - | 239472..239936 (+) | 465 | WP_002287838.1 | universal stress protein | - |
| F6447_RS01210 (F6447_01185) | ytpR | 240141..240746 (+) | 606 | WP_002294153.1 | YtpR family tRNA-binding protein | - |
| F6447_RS01215 (F6447_01190) | htrA | 240785..242074 (-) | 1290 | WP_002319485.1 | trypsin-like peptidase domain-containing protein | Regulator |
| F6447_RS01220 (F6447_01195) | rlmH | 242502..242981 (+) | 480 | WP_002345011.1 | 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH | - |
| F6447_RS01230 (F6447_01200) | - | 243334..243648 (+) | 315 | WP_000420682.1 | YdcP family protein | - |
| F6447_RS01235 (F6447_01205) | - | 243664..244050 (+) | 387 | WP_000985015.1 | YdcP family protein | - |
| F6447_RS01240 (F6447_01210) | - | 244079..245464 (+) | 1386 | WP_000813488.1 | FtsK/SpoIIIE domain-containing protein | - |
| F6447_RS01245 (F6447_01215) | - | 245467..245620 (+) | 154 | Protein_241 | conjugal transfer protein | - |
| F6447_RS01250 (F6447_01220) | mobT | 245643..246848 (+) | 1206 | WP_000398284.1 | MobT family relaxase | - |
| F6447_RS01255 (F6447_01225) | ltrA | 247632..249542 (+) | 1911 | WP_002286940.1 | group II intron reverse transcriptase/maturase | - |
| F6447_RS01260 (F6447_01230) | - | 249646..249870 (+) | 225 | WP_032509114.1 | hypothetical protein | - |
| F6447_RS01265 (F6447_01235) | - | 249987..250484 (+) | 498 | WP_002345010.1 | antirestriction protein ArdA | - |
| F6447_RS01270 (F6447_01240) | - | 250571..250963 (+) | 393 | WP_002345009.1 | conjugal transfer protein | - |
| F6447_RS01275 (F6447_01245) | - | 250947..253394 (+) | 2448 | WP_000331148.1 | ATP-binding protein | - |
| F6447_RS01280 (F6447_01250) | - | 253397..255580 (+) | 2184 | WP_002345008.1 | membrane protein | - |
| F6447_RS01285 (F6447_01255) | - | 255577..256578 (+) | 1002 | WP_002345007.1 | bifunctional lysozyme/C40 family peptidase | - |
| F6447_RS01290 (F6447_01260) | - | 256593..257507 (+) | 915 | WP_002345006.1 | conjugal transfer protein | - |
| F6447_RS01295 (F6447_01265) | - | 257752..257868 (+) | 117 | WP_001814923.1 | tetracycline resistance determinant leader peptide | - |
| F6447_RS01300 (F6447_01270) | tet(M) | 257884..259803 (+) | 1920 | WP_002345005.1 | tetracycline resistance ribosomal protection protein Tet(M) | - |
| F6447_RS01305 (F6447_01275) | tet(L) | 259901..261274 (+) | 1374 | WP_002345004.1 | tetracycline efflux MFS transporter Tet(L) | - |
| F6447_RS01315 (F6447_01280) | mobV | 261838..263100 (+) | 1263 | WP_000119405.1 | MobV family relaxase | - |
| F6447_RS01320 (F6447_01285) | - | 263345..264232 (+) | 888 | WP_085844421.1 | protein rep | - |
| F6447_RS01325 (F6447_01290) | - | 264255..264935 (-) | 681 | WP_001015311.1 | IS6-like element IS1216 family transposase | - |
| F6447_RS01335 (F6447_01295) | gadC | 266013..267524 (+) | 1512 | WP_002287851.1 | glutamate:gamma-aminobutyrate antiporter | - |
| F6447_RS01340 (F6447_01300) | - | 267537..268937 (+) | 1401 | WP_002287852.1 | glutamate decarboxylase | - |
| F6447_RS01345 (F6447_01305) | - | 269102..270538 (-) | 1437 | WP_002287854.1 | hypothetical protein | - |
| F6447_RS01350 (F6447_01310) | - | 270931..271524 (+) | 594 | WP_002287856.1 | ParB/RepB/Spo0J family partition protein | - |
| F6447_RS01355 (F6447_01315) | - | 271508..272669 (-) | 1162 | Protein_261 | IS3 family transposase | - |
| F6447_RS01360 (F6447_01320) | - | 272765..273100 (-) | 336 | Protein_262 | transposase | - |
| F6447_RS01365 (F6447_01325) | - | 273224..274687 (-) | 1464 | Protein_263 | IS1182-like element ISEfa7 family transposase | - |
| F6447_RS01370 (F6447_01330) | - | 274895..275869 (+) | 975 | WP_002298774.1 | SIS domain-containing protein | - |
| F6447_RS01375 (F6447_01335) | - | 275851..276312 (+) | 462 | WP_002312606.1 | PTS fructose transporter subunit IIA | - |
| F6447_RS01380 (F6447_01340) | - | 276362..276826 (+) | 465 | WP_002298777.1 | PTS sugar transporter subunit IIB | - |
| F6447_RS01385 (F6447_01345) | - | 276840..277589 (+) | 750 | WP_002298779.1 | PTS sugar transporter subunit IIC | - |
| F6447_RS01390 (F6447_01350) | - | 277589..278419 (+) | 831 | WP_002312607.1 | PTS system mannose/fructose/sorbose family transporter subunit IID | - |
| F6447_RS01395 (F6447_01355) | - | 278419..279066 (+) | 648 | WP_002298781.1 | HAD family phosphatase | - |
| F6447_RS01400 (F6447_01360) | - | 279164..279940 (-) | 777 | WP_002312609.1 | GntR family transcriptional regulator | - |
| F6447_RS01405 (F6447_01365) | - | 280084..281043 (+) | 960 | WP_002312610.1 | IS30 family transposase | - |
| F6447_RS01410 (F6447_01370) | - | 281160..281468 (+) | 309 | WP_002323668.1 | DUF960 domain-containing protein | - |
| F6447_RS01415 (F6447_01375) | - | 281495..281794 (+) | 300 | WP_002312614.1 | hypothetical protein | - |
| F6447_RS01420 (F6447_01380) | - | 281968..282519 (+) | 552 | WP_002312616.1 | DUF1643 domain-containing protein | - |
| F6447_RS01425 (F6447_01385) | - | 282665..282958 (+) | 294 | WP_002296258.1 | Mor transcription activator family protein | - |
| F6447_RS01430 (F6447_01390) | - | 282951..283247 (+) | 297 | WP_002312617.1 | hypothetical protein | - |
| F6447_RS01435 (F6447_01395) | - | 283318..284334 (+) | 1017 | WP_151901604.1 | DUF4767 domain-containing protein | - |
| F6447_RS01440 (F6447_01400) | - | 284780..285703 (+) | 924 | WP_002312619.1 | hypothetical protein | - |
| F6447_RS01445 (F6447_01405) | - | 285886..288561 (+) | 2676 | WP_002323671.1 | DUF927 domain-containing protein | - |
| F6447_RS01450 (F6447_01410) | - | 288743..288982 (+) | 240 | WP_002312623.1 | hypothetical protein | - |
| F6447_RS01455 (F6447_01415) | - | 288998..290371 (+) | 1374 | WP_002312624.1 | recombinase family protein | - |
| F6447_RS01460 (F6447_01420) | - | 290375..292009 (+) | 1635 | WP_002312625.1 | recombinase family protein | - |
| F6447_RS01465 (F6447_01425) | - | 292172..292378 (+) | 207 | WP_010706118.1 | hypothetical protein | - |
| F6447_RS01470 (F6447_01430) | - | 292447..293609 (+) | 1163 | WP_087043335.1 | IS3 family transposase | - |
Sequence
Protein
Download Length: 429 a.a. Molecular weight: 44898.89 Da Isoelectric Point: 4.5419
>NTDB_id=391244 F6447_RS01215 WP_002319485.1 240785..242074(-) (htrA) [Enterococcus faecium strain LAC7.2]
MDRKNVTPKMKKNKNNSLWRKLGLGLVGGIVGGLLTAGIFYAAMGTGNNSSTATSGNQNSAGETVVENVKVNVDSDITKA
VDKVQDAVVSVINLQSQNQSSGFGGLFGQQEESSSSDDSNLEAYSEGSGVIYKKDGNTAYVVTNNHVVDGQQGLEVLMKD
GTKVKAELVGTDAYSDLAVLKINSDKVETVASFGDSSALKVGEPAIAIGSPLGSEYANSVTSGIISSLNRQVTSTNESNE
TVNINAIQTDAAINPGNSGGPLVNIEGQVIGINSSKIASTSESTSNVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPALG
ITMVDLSAVSTQQQEQILKIPSSVTNGVIVTNVQTATPAEKAGLKQYDVITKIDDKEVSSGVELQSALYKKKVGDSVKIT
YYEGSKEKTTTVELTIDQSALKQNQNSEN
MDRKNVTPKMKKNKNNSLWRKLGLGLVGGIVGGLLTAGIFYAAMGTGNNSSTATSGNQNSAGETVVENVKVNVDSDITKA
VDKVQDAVVSVINLQSQNQSSGFGGLFGQQEESSSSDDSNLEAYSEGSGVIYKKDGNTAYVVTNNHVVDGQQGLEVLMKD
GTKVKAELVGTDAYSDLAVLKINSDKVETVASFGDSSALKVGEPAIAIGSPLGSEYANSVTSGIISSLNRQVTSTNESNE
TVNINAIQTDAAINPGNSGGPLVNIEGQVIGINSSKIASTSESTSNVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPALG
ITMVDLSAVSTQQQEQILKIPSSVTNGVIVTNVQTATPAEKAGLKQYDVITKIDDKEVSSGVELQSALYKKKVGDSVKIT
YYEGSKEKTTTVELTIDQSALKQNQNSEN
Nucleotide
Download Length: 1290 bp
>NTDB_id=391244 F6447_RS01215 WP_002319485.1 240785..242074(-) (htrA) [Enterococcus faecium strain LAC7.2]
ATGGATAGAAAAAATGTGACACCAAAGATGAAAAAAAATAAAAATAATAGCCTCTGGCGTAAGTTGGGTCTGGGGCTTGT
TGGAGGGATCGTTGGAGGACTACTGACAGCTGGCATTTTTTATGCAGCGATGGGCACTGGCAACAATAGTTCTACTGCTA
CAAGCGGCAATCAGAATTCTGCCGGTGAAACAGTTGTGGAAAATGTCAAAGTCAATGTAGATTCTGATATCACCAAAGCG
GTAGATAAAGTTCAAGACGCTGTCGTTTCTGTTATCAACTTACAAAGTCAAAACCAATCAAGCGGTTTTGGCGGACTATT
CGGGCAGCAAGAAGAAAGTAGCAGCTCAGATGATAGTAATTTGGAAGCTTATAGTGAAGGAAGCGGCGTGATCTACAAAA
AAGACGGGAATACTGCTTATGTAGTCACGAATAATCACGTAGTAGATGGCCAGCAAGGTCTTGAAGTCTTGATGAAAGAC
GGTACGAAGGTAAAAGCTGAATTAGTTGGAACAGATGCTTATTCAGATTTAGCGGTGTTGAAGATCAATTCAGACAAAGT
CGAAACAGTTGCCTCTTTTGGTGACTCAAGTGCTCTGAAGGTTGGTGAGCCTGCGATTGCGATTGGTTCCCCACTAGGAT
CTGAATATGCAAATTCTGTCACTTCAGGAATCATTTCTTCCTTGAACCGACAAGTGACAAGTACGAATGAATCGAACGAA
ACAGTCAATATCAATGCGATCCAAACAGATGCAGCAATCAACCCTGGAAATTCTGGTGGTCCTTTAGTTAATATCGAAGG
ACAAGTTATCGGTATCAACTCAAGTAAGATCGCAAGTACTTCTGAATCTACTTCTAATGTAAGCGTAGAAGGAATGGGAT
TTGCTATTCCAAGTAACGATGTAGTGAATATCATCAATCAACTGGAAAAAGACGGAAAAGTGACACGTCCAGCTCTAGGT
ATCACAATGGTCGACTTATCTGCCGTTTCTACTCAGCAACAAGAACAAATCTTGAAGATTCCTTCATCTGTAACTAACGG
TGTCATCGTGACAAATGTCCAAACAGCTACACCGGCTGAAAAAGCTGGATTGAAACAATACGACGTCATTACTAAGATCG
ATGACAAAGAAGTTTCTTCTGGTGTAGAACTTCAATCTGCTTTGTATAAGAAAAAAGTGGGAGATTCTGTCAAAATCACT
TACTATGAAGGCTCGAAAGAAAAAACAACTACTGTTGAATTGACGATCGATCAATCGGCATTAAAACAAAATCAAAATAG
TGAAAATTAA
ATGGATAGAAAAAATGTGACACCAAAGATGAAAAAAAATAAAAATAATAGCCTCTGGCGTAAGTTGGGTCTGGGGCTTGT
TGGAGGGATCGTTGGAGGACTACTGACAGCTGGCATTTTTTATGCAGCGATGGGCACTGGCAACAATAGTTCTACTGCTA
CAAGCGGCAATCAGAATTCTGCCGGTGAAACAGTTGTGGAAAATGTCAAAGTCAATGTAGATTCTGATATCACCAAAGCG
GTAGATAAAGTTCAAGACGCTGTCGTTTCTGTTATCAACTTACAAAGTCAAAACCAATCAAGCGGTTTTGGCGGACTATT
CGGGCAGCAAGAAGAAAGTAGCAGCTCAGATGATAGTAATTTGGAAGCTTATAGTGAAGGAAGCGGCGTGATCTACAAAA
AAGACGGGAATACTGCTTATGTAGTCACGAATAATCACGTAGTAGATGGCCAGCAAGGTCTTGAAGTCTTGATGAAAGAC
GGTACGAAGGTAAAAGCTGAATTAGTTGGAACAGATGCTTATTCAGATTTAGCGGTGTTGAAGATCAATTCAGACAAAGT
CGAAACAGTTGCCTCTTTTGGTGACTCAAGTGCTCTGAAGGTTGGTGAGCCTGCGATTGCGATTGGTTCCCCACTAGGAT
CTGAATATGCAAATTCTGTCACTTCAGGAATCATTTCTTCCTTGAACCGACAAGTGACAAGTACGAATGAATCGAACGAA
ACAGTCAATATCAATGCGATCCAAACAGATGCAGCAATCAACCCTGGAAATTCTGGTGGTCCTTTAGTTAATATCGAAGG
ACAAGTTATCGGTATCAACTCAAGTAAGATCGCAAGTACTTCTGAATCTACTTCTAATGTAAGCGTAGAAGGAATGGGAT
TTGCTATTCCAAGTAACGATGTAGTGAATATCATCAATCAACTGGAAAAAGACGGAAAAGTGACACGTCCAGCTCTAGGT
ATCACAATGGTCGACTTATCTGCCGTTTCTACTCAGCAACAAGAACAAATCTTGAAGATTCCTTCATCTGTAACTAACGG
TGTCATCGTGACAAATGTCCAAACAGCTACACCGGCTGAAAAAGCTGGATTGAAACAATACGACGTCATTACTAAGATCG
ATGACAAAGAAGTTTCTTCTGGTGTAGAACTTCAATCTGCTTTGTATAAGAAAAAAGTGGGAGATTCTGTCAAAATCACT
TACTATGAAGGCTCGAAAGAAAAAACAACTACTGTTGAATTGACGATCGATCAATCGGCATTAAAACAAAATCAAAATAG
TGAAAATTAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| htrA | Streptococcus gordonii str. Challis substr. CH1 |
54.569 |
91.841 |
0.501 |
| htrA | Streptococcus mutans UA159 |
59.887 |
82.517 |
0.494 |
| htrA | Streptococcus mitis NCTC 12261 |
52.778 |
92.308 |
0.487 |
| htrA | Streptococcus pneumoniae TIGR4 |
59.05 |
78.555 |
0.464 |
| htrA | Streptococcus pneumoniae Rx1 |
59.05 |
78.555 |
0.464 |
| htrA | Streptococcus pneumoniae D39 |
59.05 |
78.555 |
0.464 |
| htrA | Streptococcus pneumoniae R6 |
59.05 |
78.555 |
0.464 |