Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   LPB220_RS02330 Genome accession   NZ_CP044230
Coordinates   429044..429781 (+) Length   245 a.a.
NCBI ID   WP_049503933.1    Uniprot ID   A0A4Q2FCR8
Organism   Streptococcus sp. LPB0220     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 424044..434781
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  LPB220_RS02315 (LPB220_02315) - 424376..425938 (-) 1563 WP_049497670.1 ABC transporter substrate-binding protein/permease -
  LPB220_RS02320 (LPB220_02320) - 426056..427963 (+) 1908 WP_150905370.1 DUF2207 domain-containing protein -
  LPB220_RS02325 (LPB220_02325) - 428072..428908 (+) 837 WP_003010265.1 undecaprenyl-diphosphate phosphatase -
  LPB220_RS02330 (LPB220_02330) mecA 429044..429781 (+) 738 WP_049503933.1 adaptor protein MecA Regulator
  LPB220_RS02335 (LPB220_02335) - 429778..430935 (+) 1158 WP_042760185.1 glycosyltransferase family 4 protein -
  LPB220_RS02340 (LPB220_02340) sufC 431071..431841 (+) 771 WP_003004238.1 Fe-S cluster assembly ATPase SufC -
  LPB220_RS02345 (LPB220_02345) sufD 431908..433170 (+) 1263 WP_024056229.1 Fe-S cluster assembly protein SufD -
  LPB220_RS02350 (LPB220_02350) - 433180..434406 (+) 1227 WP_150905372.1 cysteine desulfurase -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28258.83 Da        Isoelectric Point: 4.0867

>NTDB_id=388970 LPB220_RS02330 WP_049503933.1 429044..429781(+) (mecA) [Streptococcus sp. LPB0220]
MKMKQISDSTIKITIQLEDLEERGMEIADFLVPQEKTEEFFYTILDELEMPESFLDSGMLSFRVTPKPDKLDVFVTKSKI
DQQLDFEDLSDLPDMEELSRMTPDEFIKTLEKTISDKTKGDAEAIHHLEQEELRDNQEQDSTSEAPVSQYIYYILRFSNI
QQAVAFSKTVSFPVDTSELYKMGSDYYLTVLIDTEDQPNQYPTWLLAIIREYADDSEVTRAVLQEHGHLLMVSGAIENLK
KVASL

Nucleotide


Download         Length: 738 bp        

>NTDB_id=388970 LPB220_RS02330 WP_049503933.1 429044..429781(+) (mecA) [Streptococcus sp. LPB0220]
ATGAAGATGAAGCAAATTAGTGATTCAACAATTAAGATCACAATCCAACTAGAAGACTTAGAAGAACGTGGGATGGAAAT
TGCTGATTTCCTTGTCCCACAAGAAAAAACAGAAGAATTTTTCTACACTATTTTGGATGAGCTCGAAATGCCTGAAAGCT
TCCTGGATAGCGGGATGCTGAGTTTCCGTGTGACACCAAAACCAGATAAATTGGATGTTTTTGTTACCAAATCAAAAATT
GACCAACAATTGGATTTTGAGGATTTGTCAGATCTTCCTGATATGGAAGAGTTGTCGCGCATGACGCCAGATGAATTTAT
CAAAACCTTGGAAAAAACAATCTCTGATAAGACAAAAGGGGATGCAGAAGCCATTCACCATTTGGAACAAGAAGAGTTGC
GGGACAATCAAGAACAAGATTCGACATCTGAAGCACCAGTAAGCCAGTATATTTATTACATTTTGCGTTTTTCCAATATC
CAGCAAGCAGTTGCTTTTTCAAAAACGGTAAGCTTTCCAGTGGATACCTCTGAATTATACAAAATGGGATCCGATTATTA
TTTAACCGTCTTGATCGATACAGAGGATCAACCAAATCAATATCCAACCTGGTTACTTGCTATCATTCGGGAGTATGCGG
ATGATTCAGAAGTGACACGGGCAGTTCTGCAGGAACATGGTCATTTATTAATGGTGTCTGGTGCGATTGAGAATTTGAAG
AAAGTTGCTAGCTTATGA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A4Q2FCR8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus pneumoniae Rx1

68.163

100

0.682
  mecA Streptococcus pneumoniae D39

68.163

100

0.682
  mecA Streptococcus pneumoniae R6

68.163

100

0.682
  mecA Streptococcus pneumoniae TIGR4

68.163

100

0.682
  mecA Streptococcus mutans UA159

50.202

100

0.506
  mecA Streptococcus thermophilus LMD-9

47.967

100

0.482
  mecA Streptococcus thermophilus LMG 18311

47.561

100

0.478

Multiple sequence alignment