Detailed information NTG0385795

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: HG697_RS02965
• Genome accession: NZ_CP051623
• Coordinates: 545213..545962 (+)
• Length: 249 a.a.
• NCBI ID: WP_015057380.1
• Uniprot ID: -
• Organism: Streptococcus dysgalactiae subsp. equisimilis strain TPCH-A19
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 540213..550962

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HG697_RS02935 (HG697_02940)	-	540435..541694 (-)	1260	Protein_524	ABC transporter transmembrane domain-containing protein	-
HG697_RS02940 (HG697_02945)	-	541998..542225 (+)	228	WP_003062179.1	hypothetical protein	-
HG697_RS02945 (HG697_02950)	-	542274..542591 (+)	318	WP_002994587.1	hypothetical protein	-
HG697_RS02950 (HG697_02955)	-	542999..543238 (+)	240	WP_003054359.1	Blp family class II bacteriocin	-
HG697_RS02955 (HG697_02960)	-	543252..543437 (+)	186	WP_003054392.1	hypothetical protein	-
HG697_RS02960 (HG697_02965)	-	543859..544965 (-)	1107	Protein_529	IS3 family transposase	-
HG697_RS02965 (HG697_02970)	comE/blpR	545213..545962 (+)	750	WP_015057380.1	response regulator transcription factor	Regulator
HG697_RS02970 (HG697_02975)	comD/blpH	546367..547296 (+)	930	WP_240954823.1	GHKL domain-containing protein	Regulator
HG697_RS02975 (HG697_02980)	-	547444..547569 (-)	126	WP_011017462.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
HG697_RS02980 (HG697_02985)	-	547646..549010 (-)	1365	WP_015057382.1	bacteriocin secretion accessory protein	-

Sequence

Protein

• Length: 249 a.a.
• Molecular weight: 29137.45 Da
• Isoelectric Point: 5.8302

>NTDB_id=385795 HG697_RS02965 WP_015057380.1 545213..545962(+) (comE/blpR) [Streptococcus dysgalactiae subsp. equisimilis strain TPCH-A19]
MNIFVLEDDFLHQTRIEKIIYKILTDNKLEVNHLEVYGKPNQLLEDISERGRHQLFFLDIDIKGEDKKGMEIAVEIRNKD
PHAVIVFVTTHSEFMPVSFQYQVSALDFIDKELPEELFSHRIEKAISYVQDNQGKTLAEDSFVFTNVKSQIQVPFSDLLY
IETSLIPHKLILYSTKQRVEFYGQLSEIVEQDDRLFQCHRSFVVNPYNISSIDRSERLVYLKGGLSCIVSRLKIRSLIKV
VEELHTKEK

Nucleotide

• Length: 750 bp

>NTDB_id=385795 HG697_RS02965 WP_015057380.1 545213..545962(+) (comE/blpR) [Streptococcus dysgalactiae subsp. equisimilis strain TPCH-A19]
ATGAATATTTTTGTCTTAGAGGACGATTTTTTACATCAAACCAGAATTGAAAAAATTATTTATAAGATTTTGACTGATAA
TAAGTTGGAGGTTAACCACTTGGAAGTTTATGGTAAACCCAATCAGCTGCTTGAAGATATATCAGAGAGAGGAAGACATC
AGCTTTTTTTTCTTGACATTGACATTAAGGGAGAAGATAAAAAAGGAATGGAAATTGCTGTGGAGATTAGAAATAAAGAT
CCGCACGCAGTGATAGTTTTTGTGACCACACATTCAGAATTTATGCCGGTATCTTTTCAATACCAGGTTTCAGCTTTAGA
CTTTATTGACAAAGAGTTGCCAGAGGAGTTATTTAGTCATCGCATTGAAAAAGCTATAAGTTATGTACAAGATAACCAAG
GAAAAACGTTAGCGGAGGATTCATTTGTTTTTACTAATGTAAAGTCCCAGATACAAGTCCCCTTTTCAGATTTGCTGTAT
ATTGAAACCTCACTAATTCCCCATAAACTCATTCTCTATTCTACTAAACAAAGAGTAGAATTTTATGGCCAATTATCAGA
AATTGTTGAGCAAGATGATCGATTATTTCAATGTCATCGTTCCTTTGTTGTTAATCCCTATAATATATCATCAATAGATA
GATCCGAACGGTTAGTTTATTTAAAGGGGGGATTATCTTGTATTGTTTCGAGATTGAAAATACGATCATTAATAAAAGTA
GTAGAAGAGTTGCACACTAAGGAGAAATAG

Domains

Predicted by InterProScan.

• Response regulator receiver domain (Response_reg) (3-119)

• LytTr DNA-binding domain (LytTR) (150-239)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	54.508	97.992	0.534
comE/comE2	Streptococcus gordonii strain NCTC7865	40.873	100	0.414
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	40.873	100	0.414
comE/comE1	Streptococcus equinus JB1	42.437	95.582	0.406
comE/comE2	Streptococcus equinus JB1	40.984	97.992	0.402
comE	Streptococcus mitis SK321	38.8	100	0.39
comE	Streptococcus mitis NCTC 12261	38.8	100	0.39
comE	Streptococcus pneumoniae TIGR4	38.4	100	0.386
comE	Streptococcus pneumoniae Rx1	38.4	100	0.386
comE	Streptococcus pneumoniae D39	38.4	100	0.386
comE	Streptococcus pneumoniae R6	38.4	100	0.386
comE	Streptococcus infantis strain Atu-4	38.306	99.598	0.382