Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   FGL73_RS08170 Genome accession   NZ_CP042408
Coordinates   1699292..1700518 (+) Length   408 a.a.
NCBI ID   WP_038602386.1    Uniprot ID   Q66RS2
Organism   Lactococcus lactis strain CBA3619     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1694292..1705518
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  FGL73_RS08145 (FGL73_08145) - 1695384..1696187 (-) 804 WP_038602374.1 phosphatidate cytidylyltransferase -
  FGL73_RS08150 (FGL73_08150) - 1696187..1696921 (-) 735 WP_003130589.1 isoprenyl transferase -
  FGL73_RS08155 (FGL73_08155) yajC 1697293..1697625 (-) 333 WP_021721860.1 preprotein translocase subunit YajC -
  FGL73_RS08160 (FGL73_08160) - 1697720..1698418 (-) 699 WP_146978282.1 DNA alkylation repair protein -
  FGL73_RS08165 (FGL73_08165) rlmH 1698437..1698916 (-) 480 WP_058205116.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  FGL73_RS08170 (FGL73_08170) htrA 1699292..1700518 (+) 1227 WP_038602386.1 S1C family serine protease Regulator
  FGL73_RS08175 (FGL73_08175) - 1700644..1701642 (+) 999 WP_021721856.1 glycosyltransferase family 4 protein -
  FGL73_RS08180 (FGL73_08180) - 1701768..1703108 (+) 1341 WP_146978283.1 glycosyltransferase family 4 protein -
  FGL73_RS08185 (FGL73_08185) - 1703216..1703440 (+) 225 WP_003130579.1 YkuJ family protein -
  FGL73_RS08190 (FGL73_08190) - 1703577..1704581 (+) 1005 WP_021721854.1 hypothetical protein -
  FGL73_RS08195 (FGL73_08195) - 1704622..1705374 (-) 753 WP_010906333.1 tRNA1(Val) (adenine(37)-N6)-methyltransferase -

Sequence

Protein


Download         Length: 408 a.a.        Molecular weight: 41664.01 Da        Isoelectric Point: 4.9794

>NTDB_id=377725 FGL73_RS08170 WP_038602386.1 1699292..1700518(+) (htrA) [Lactococcus lactis strain CBA3619]
MAKANIGKLLLTGVVGGAIALGGSAIYQSTTNQLANNSRSNTTSTKVSNVSVNVNTDVTSAIKKVSNSVVSVMNYQKDNS
QSSDFSSIFGGNSGSSSSTDGLQLSSEGSGVIYKKSGGDAYVVTNYHVIAGNSSLDVLLSGGQKVKASVVGYDEYTDLAV
LKISSEHVKDVATFADSSKLTIGEPAIAVGSPLGSQFANTATEGILSATSRQVTLTQENGQTTNINAIQTDAAINPGNSG
GALINIEGQVIGITQSKITTTEDGSTSVEGLGFAIPSNDVVNIINKLEADGKISRPALGIRMVDLSQLSTNDSSQLKLPS
SVTGGVVVYSVQSGLPAASAGLKAGDVITKVGDTAVTSSTDLQSALYSHNINDTVKVTYYRDGKSNTADVKLSKSTSDLE
TSSSSSSN

Nucleotide


Download         Length: 1227 bp        

>NTDB_id=377725 FGL73_RS08170 WP_038602386.1 1699292..1700518(+) (htrA) [Lactococcus lactis strain CBA3619]
ATGGCAAAAGCTAATATAGGAAAATTGCTATTAACAGGTGTCGTGGGCGGAGCCATCGCACTTGGAGGAAGTGCAATCTA
TCAAAGCACTACAAATCAATTGGCAAATAATAGTCGTTCAAATACAACTAGCACAAAGGTTAGTAACGTTTCAGTAAATG
TCAACACCGATGTTACCTCTGCGATTAAAAAAGTTTCAAATTCTGTCGTTTCTGTTATGAATTATCAAAAAGATAACTCA
CAAAGTAGTGACTTCAGTTCAATTTTTGGTGGAAATAGTGGTTCAAGTTCATCGACTGATGGCTTACAGCTTTCTAGTGA
AGGCTCTGGTGTCATCTACAAAAAATCTGGTGGAGATGCCTACGTTGTAACTAACTACCACGTTATTGCTGGTAATAGTT
CACTCGATGTTCTGCTTTCTGGTGGACAAAAAGTCAAAGCTTCTGTGGTTGGTTATGATGAATACACAGACCTTGCTGTT
CTTAAAATCAGTTCTGAACATGTCAAAGATGTGGCGACATTCGCTGATTCTAGTAAATTAACAATTGGTGAACCTGCCAT
TGCCGTTGGCTCACCTTTAGGTAGTCAATTTGCTAATACCGCAACTGAAGGAATTTTATCTGCAACAAGCCGTCAAGTGA
CTTTGACCCAAGAAAATGGTCAAACAACTAATATCAATGCAATTCAAACAGATGCTGCCATTAACCCTGGTAACTCTGGA
GGGGCTTTGATTAATATTGAAGGGCAAGTTATTGGAATTACTCAAAGTAAAATTACAACAACTGAAGACGGTTCTACTTC
TGTCGAAGGTTTAGGATTTGCGATTCCTTCTAACGATGTCGTAAATATCATTAATAAACTTGAAGCTGATGGTAAGATTT
CACGCCCTGCTTTAGGTATCCGAATGGTTGACCTTTCACAATTATCAACAAATGATAGTTCACAATTGAAATTACCAAGT
AGTGTAACAGGTGGGGTTGTTGTTTACTCCGTCCAATCTGGACTTCCTGCTGCCTCAGCCGGTTTGAAAGCTGGAGATGT
AATTACAAAGGTTGGCGATACAGCAGTAACTTCTTCAACAGACTTGCAAAGTGCTCTTTACTCACACAATATCAATGATA
CAGTAAAAGTTACTTATTATCGTGATGGTAAATCAAACACAGCAGATGTTAAACTTTCTAAATCAACCAGTGACTTAGAA
ACAAGCAGTTCATCTTCTTCTAATTAA

Domains

Predicted by InterproScan.

PDZ domain (PDZ_2)

(296-392)

Trypsin-like peptidase domain (Trypsin_2)

(108-253)

Peptidase family M50 (Peptidase_M50)

(223-396)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q66RS2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mitis NCTC 12261

56.283

93.627

0.527
  htrA Streptococcus gordonii str. Challis substr. CH1

54.476

95.833

0.522
  htrA Streptococcus pneumoniae D39

58.309

84.069

0.49
  htrA Streptococcus pneumoniae TIGR4

58.309

84.069

0.49
  htrA Streptococcus pneumoniae R6

58.309

84.069

0.49
  htrA Streptococcus pneumoniae Rx1

58.309

84.069

0.49
  htrA Streptococcus mutans UA159

53.279

89.706

0.478

Multiple sequence alignment