Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   FQ488_RS11975 Genome accession   NZ_CP042289
Coordinates   2550686..2551972 (+) Length   428 a.a.
NCBI ID   WP_010737045.1    Uniprot ID   A0A2A4DST9
Organism   Enterococcus hirae strain HDC14-2     
Function   require for competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 2545686..2556972
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  FQ488_RS11955 (FQ488_12040) - 2547297..2547980 (+) 684 WP_002309708.1 PHP domain-containing protein -
  FQ488_RS11960 (FQ488_12045) - 2548017..2548514 (-) 498 WP_002295755.1 GNAT family N-acetyltransferase -
  FQ488_RS11965 (FQ488_12050) - 2548570..2549478 (-) 909 WP_002332708.1 IS982-like element ISEfm1 family transposase -
  FQ488_RS11970 (FQ488_12055) rlmH 2549754..2550233 (-) 480 WP_185184785.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  FQ488_RS11975 (FQ488_12060) htrA 2550686..2551972 (+) 1287 WP_010737045.1 S1C family serine protease Regulator
  FQ488_RS11980 (FQ488_12065) ytpR 2552030..2552635 (-) 606 WP_010737044.1 YtpR family tRNA-binding protein -
  FQ488_RS11985 (FQ488_12070) - 2552944..2553411 (-) 468 WP_185184786.1 universal stress protein -
  FQ488_RS11990 (FQ488_12075) - 2553441..2553761 (-) 321 WP_010737043.1 thioredoxin family protein -
  FQ488_RS11995 (FQ488_12080) pepA 2554298..2555377 (-) 1080 WP_010720947.1 glutamyl aminopeptidase -
  FQ488_RS12000 (FQ488_12085) - 2555576..2555929 (+) 354 WP_002317104.1 PepSY domain-containing protein -

Sequence

Protein


Download         Length: 428 a.a.        Molecular weight: 44581.68 Da        Isoelectric Point: 4.7976

>NTDB_id=376672 FQ488_RS11975 WP_010737045.1 2550686..2551972(+) (htrA) [Enterococcus hirae strain HDC14-2]
MERKDVTPKMKKNNGIWRKLGLGLVGGIIGGLVTAGIFYAVMGSGNAASNSGGHQNSAGETVVENVKVNVDSDITNAVDK
VQDAVVSVINLQSQNQGTNGFGQLFGQQQQESSDDSNLEASSEGSGVIYKKSGNSAYIVTNNHVVEGQQGLEVLLKDGTK
VKAELVGTDAYSDLAVLKISADKVNKVASFGDSNSLKVGEPAIAIGSPLGSEYANSVTSGIISSLNRQVTSTNESNQTVN
INAIQTDAAINPGNSGGPLVNIEGQVIGINSSKIASTSASSSGVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPALGITM
VDLSAVSTQQQEQILKIPESVTNGVIVTSVQPATPAEKAGLKQYDVITKIDDTDVSSGVELQSVLYQKKVGDSVKVTYYR
GKEKKTTTIQLTIDQSALKQSQSENSGN

Nucleotide


Download         Length: 1287 bp        

>NTDB_id=376672 FQ488_RS11975 WP_010737045.1 2550686..2551972(+) (htrA) [Enterococcus hirae strain HDC14-2]
ATGGAGAGAAAAGATGTGACACCAAAAATGAAAAAGAATAATGGAATCTGGCGTAAGCTGGGTCTAGGCTTAGTCGGTGG
AATTATTGGGGGCTTGGTAACGGCTGGTATTTTTTATGCTGTCATGGGTTCTGGAAACGCAGCGTCAAATTCGGGTGGTC
ATCAAAATTCAGCGGGCGAAACTGTCGTTGAGAATGTCAAAGTCAATGTCGATTCAGATATTACGAATGCGGTCGATAAA
GTCCAAGATGCGGTGGTATCTGTTATCAATCTTCAAAGCCAAAATCAAGGGACCAACGGCTTTGGGCAACTGTTTGGCCA
ACAACAACAAGAAAGTTCTGATGATAGCAACCTAGAGGCTTCTAGTGAAGGTAGTGGTGTCATCTACAAAAAAAGTGGTA
ATTCCGCTTATATCGTAACGAATAATCACGTAGTGGAAGGCCAACAAGGATTAGAAGTTTTATTAAAAGATGGAACAAAA
GTCAAAGCTGAATTAGTCGGGACGGATGCTTATTCTGACTTAGCCGTTTTGAAAATCAGTGCAGATAAAGTGAACAAAGT
TGCTTCATTTGGTGACTCTAATTCATTGAAAGTAGGTGAACCGGCGATCGCAATTGGTTCTCCTTTAGGTTCTGAATATG
CCAACTCTGTGACTTCGGGGATTATCTCTTCATTGAATCGCCAAGTAACCAGCACGAACGAGTCAAATCAAACGGTCAAT
ATCAATGCGATCCAAACAGATGCTGCGATCAACCCTGGTAATTCTGGTGGTCCATTAGTTAATATCGAAGGTCAAGTGAT
CGGGATCAATTCAAGTAAAATTGCAAGTACTTCTGCTTCTTCATCAGGTGTAAGCGTGGAAGGAATGGGCTTTGCGATCC
CAAGTAACGATGTAGTAAATATTATCAACCAACTTGAAAAAGATGGAAAAGTAACCCGTCCTGCTCTAGGGATCACAATG
GTTGACCTTTCAGCCGTTTCAACCCAACAACAAGAACAAATCTTGAAAATTCCTGAATCTGTGACAAATGGTGTGATTGT
TACCAGCGTTCAACCGGCGACACCTGCAGAAAAAGCTGGCTTGAAACAATATGATGTCATTACAAAAATCGATGATACTG
ATGTTTCTTCTGGTGTAGAATTACAATCTGTCTTGTATCAGAAAAAAGTCGGCGATTCAGTGAAGGTCACTTACTATCGC
GGAAAAGAAAAGAAAACAACAACAATTCAATTAACAATTGATCAATCCGCATTAAAACAAAGCCAATCAGAGAACTCTGG
TAACTAA

Domains

Predicted by InterproScan.

Trypsin-like peptidase domain (Trypsin_2)

(124-269)

PDZ domain (PDZ_2)

(314-411)

Peptidase family M50 (Peptidase_M50)

(12-414)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2A4DST9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mutans UA159

54.545

92.523

0.505
  htrA Streptococcus gordonii str. Challis substr. CH1

53.35

94.159

0.502
  htrA Streptococcus pneumoniae Rx1

58.457

78.738

0.46
  htrA Streptococcus pneumoniae D39

58.457

78.738

0.46
  htrA Streptococcus pneumoniae R6

58.457

78.738

0.46
  htrA Streptococcus pneumoniae TIGR4

58.457

78.738

0.46
  htrA Streptococcus mitis NCTC 12261

57.567

78.738

0.453

Multiple sequence alignment