Detailed information
Bioinformatically predicted
Overview
| Name | htrA | Type | Regulator |
| Locus tag | FPL13_RS09080 | Genome accession | NZ_CP041968 |
| Coordinates | 1835793..1836983 (-) | Length | 396 a.a. |
| NCBI ID | WP_049512719.1 | Uniprot ID | A0A7L8W7E4 |
| Organism | Streptococcus sp. KS 6 | ||
| Function | repress competence development (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| Prophage | 1791697..1871002 | 1835793..1836983 | within | 0 |
Gene organization within MGE regions
Location: 1791697..1871002
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FPL13_RS08810 (FPL13_08935) | - | 1792437..1792679 (-) | 243 | WP_049514295.1 | hypothetical protein | - |
| FPL13_RS08815 (FPL13_08940) | - | 1793279..1795213 (+) | 1935 | WP_049514291.1 | GBS Bsp-like repeat-containing protein | - |
| FPL13_RS08820 (FPL13_08945) | purH | 1795272..1796819 (-) | 1548 | WP_049514289.1 | bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase | - |
| FPL13_RS08825 (FPL13_08950) | - | 1796827..1796991 (-) | 165 | WP_049514287.1 | hypothetical protein | - |
| FPL13_RS08830 (FPL13_08955) | purN | 1797046..1797597 (-) | 552 | WP_049514285.1 | phosphoribosylglycinamide formyltransferase | - |
| FPL13_RS08835 (FPL13_08960) | purM | 1797597..1798616 (-) | 1020 | WP_049514284.1 | phosphoribosylformylglycinamidine cyclo-ligase | - |
| FPL13_RS08840 (FPL13_08965) | purF | 1798852..1800315 (-) | 1464 | WP_049514282.1 | amidophosphoribosyltransferase | - |
| FPL13_RS08845 (FPL13_08970) | - | 1800406..1804131 (-) | 3726 | WP_049514281.1 | phosphoribosylformylglycinamidine synthase | - |
| FPL13_RS08850 (FPL13_08975) | purC | 1804178..1804885 (-) | 708 | WP_003032064.1 | phosphoribosylaminoimidazolesuccinocarboxamide synthase | - |
| FPL13_RS08855 (FPL13_08980) | - | 1805045..1805290 (-) | 246 | WP_049514280.1 | acyl carrier protein | - |
| FPL13_RS08860 (FPL13_08985) | plsX | 1805287..1806285 (-) | 999 | WP_049514278.1 | phosphate acyltransferase PlsX | - |
| FPL13_RS08865 (FPL13_08990) | recO | 1806282..1807054 (-) | 773 | Protein_1745 | DNA repair protein RecO | - |
| FPL13_RS08870 (FPL13_08995) | - | 1807032..1808219 (-) | 1188 | WP_049514274.1 | pyridoxal phosphate-dependent aminotransferase | - |
| FPL13_RS08875 (FPL13_09000) | - | 1808374..1809342 (-) | 969 | WP_049514273.1 | ribose-phosphate diphosphokinase | - |
| FPL13_RS08880 (FPL13_09005) | pcsB | 1809475..1810698 (-) | 1224 | WP_049514271.1 | peptidoglycan hydrolase PcsB | - |
| FPL13_RS08885 (FPL13_09010) | mreD | 1810808..1811308 (-) | 501 | WP_049514270.1 | rod shape-determining protein MreD | - |
| FPL13_RS08890 (FPL13_09015) | mreC | 1811310..1812116 (-) | 807 | WP_049514268.1 | rod shape-determining protein MreC | - |
| FPL13_RS09005 (FPL13_09130) | comR/comR2 | 1819385..1819858 (-) | 474 | WP_192208621.1 | sigma-70 family RNA polymerase sigma factor | Regulator |
| FPL13_RS09010 (FPL13_09135) | ftsH | 1820061..1822031 (-) | 1971 | WP_049512744.1 | ATP-dependent zinc metalloprotease FtsH | - |
| FPL13_RS09015 (FPL13_09140) | hpt | 1822052..1822594 (-) | 543 | WP_049512741.1 | hypoxanthine phosphoribosyltransferase | - |
| FPL13_RS09020 (FPL13_09145) | tilS | 1822600..1823877 (-) | 1278 | Protein_1754 | tRNA lysidine(34) synthetase TilS | - |
| FPL13_RS09025 (FPL13_09150) | - | 1823874..1825154 (-) | 1281 | WP_049512737.1 | serine hydrolase | - |
| FPL13_RS09875 (FPL13_09155) | - | 1825147..1825275 (-) | 129 | WP_152907026.1 | SP_0009 family protein | - |
| FPL13_RS09030 (FPL13_09160) | - | 1825278..1825646 (-) | 369 | WP_003026832.1 | septum formation initiator family protein | - |
| FPL13_RS09035 (FPL13_09165) | - | 1825639..1825905 (-) | 267 | WP_049512735.1 | RNA-binding S4 domain-containing protein | - |
| FPL13_RS09040 (FPL13_09170) | mfd | 1825985..1829491 (-) | 3507 | WP_152907025.1 | transcription-repair coupling factor | - |
| FPL13_RS09045 (FPL13_09175) | pth | 1829484..1830053 (-) | 570 | WP_003032454.1 | aminoacyl-tRNA hydrolase | - |
| FPL13_RS09050 (FPL13_09180) | ychF | 1830126..1831241 (-) | 1116 | WP_049512731.1 | redox-regulated ATPase YchF | - |
| FPL13_RS09055 (FPL13_09185) | - | 1831387..1831887 (+) | 501 | WP_049512729.1 | YehR family protein | - |
| FPL13_RS09060 (FPL13_09190) | - | 1831919..1832107 (-) | 189 | WP_192208622.1 | DUF951 domain-containing protein | - |
| FPL13_RS09065 (FPL13_09195) | dnaN | 1832107..1833243 (-) | 1137 | WP_049512726.1 | DNA polymerase III subunit beta | - |
| FPL13_RS09070 (FPL13_09200) | dnaA | 1833400..1834644 (-) | 1245 | WP_412556309.1 | chromosomal replication initiator protein DnaA | - |
| FPL13_RS09075 (FPL13_09205) | spo0J | 1834971..1835738 (-) | 768 | WP_049512721.1 | ParB/RepB/Spo0J family partition protein | Regulator |
| FPL13_RS09080 (FPL13_09210) | htrA | 1835793..1836983 (-) | 1191 | WP_049512719.1 | S1C family serine protease | Regulator |
| FPL13_RS09085 (FPL13_09215) | rlmH | 1837176..1837655 (+) | 480 | WP_049512717.1 | 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH | - |
| FPL13_RS09095 (FPL13_09225) | - | 1837936..1838082 (+) | 147 | WP_003029519.1 | bacteriocin | - |
| FPL13_RS09100 (FPL13_09230) | comD/comD2 | 1838103..1839425 (+) | 1323 | WP_405187536.1 | sensor histidine kinase | Regulator |
| FPL13_RS09105 (FPL13_09235) | comE | 1839425..1840173 (+) | 749 | Protein_1771 | competence system response regulator transcription factor ComE | - |
| FPL13_RS09110 (FPL13_09240) | - | 1840280..1841225 (+) | 946 | Protein_1772 | IS30 family transposase | - |
| FPL13_RS09125 (FPL13_09255) | - | 1841622..1844196 (-) | 2575 | Protein_1773 | YfhO family protein | - |
| FPL13_RS09130 (FPL13_09260) | - | 1844263..1845885 (-) | 1623 | WP_049514030.1 | ATP-binding cassette domain-containing protein | - |
| FPL13_RS09135 (FPL13_09265) | - | 1846041..1846580 (+) | 540 | WP_049514031.1 | NAD(P)H-dependent oxidoreductase | - |
| FPL13_RS09140 (FPL13_09270) | - | 1846602..1847291 (+) | 690 | WP_049514032.1 | triose-phosphate isomerase | - |
| FPL13_RS09145 (FPL13_09275) | galE | 1847311..1848306 (+) | 996 | WP_065428428.1 | UDP-glucose 4-epimerase GalE | - |
| FPL13_RS09150 (FPL13_09280) | trpS | 1848388..1849413 (+) | 1026 | WP_049514033.1 | tryptophan--tRNA ligase | - |
| FPL13_RS09155 (FPL13_09285) | guaB | 1849545..1851026 (+) | 1482 | WP_049514035.1 | IMP dehydrogenase | - |
| FPL13_RS09160 (FPL13_09290) | recF | 1851115..1852212 (-) | 1098 | WP_049514036.1 | DNA replication/repair protein RecF | - |
| FPL13_RS09165 (FPL13_09295) | yaaA | 1852214..1852594 (-) | 381 | WP_003038263.1 | S4 domain-containing protein YaaA | - |
| FPL13_RS09170 (FPL13_09300) | yfmF | 1852770..1854017 (+) | 1248 | WP_049514038.1 | EF-P 5-aminopentanol modification-associated protein YfmF | - |
| FPL13_RS09175 (FPL13_09305) | yfmH | 1854017..1855312 (+) | 1296 | WP_049514040.1 | EF-P 5-aminopentanol modification-associated protein YfmH | - |
| FPL13_RS09180 (FPL13_09310) | rodZ | 1855371..1856192 (+) | 822 | WP_049514041.1 | cytoskeleton protein RodZ | - |
| FPL13_RS09185 (FPL13_09315) | pgsA | 1856203..1856742 (+) | 540 | WP_049514043.1 | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase | - |
| FPL13_RS09190 (FPL13_09320) | - | 1856744..1857571 (+) | 828 | WP_049514045.1 | energy-coupling factor ABC transporter ATP-binding protein | - |
| FPL13_RS09195 (FPL13_09325) | - | 1857556..1858395 (+) | 840 | WP_049514046.1 | energy-coupling factor transporter ATPase | - |
| FPL13_RS09200 (FPL13_09330) | - | 1858388..1859182 (+) | 795 | WP_049514048.1 | energy-coupling factor transporter transmembrane component T family protein | - |
| FPL13_RS09205 (FPL13_09335) | - | 1859338..1859958 (+) | 621 | WP_003031567.1 | LysM peptidoglycan-binding domain-containing protein | - |
| FPL13_RS09210 (FPL13_09340) | - | 1860096..1860752 (-) | 657 | WP_049514050.1 | HAD hydrolase-like protein | - |
| FPL13_RS09215 (FPL13_09345) | sdaAA | 1860805..1861677 (-) | 873 | WP_049514052.1 | L-serine ammonia-lyase, iron-sulfur-dependent, subunit alpha | - |
| FPL13_RS09220 (FPL13_09350) | sdaAB | 1861686..1862357 (-) | 672 | WP_049514053.1 | L-serine ammonia-lyase, iron-sulfur-dependent subunit beta | - |
| FPL13_RS09225 (FPL13_09355) | - | 1862604..1863131 (+) | 528 | WP_049514055.1 | LysM peptidoglycan-binding domain-containing protein | - |
| FPL13_RS09230 (FPL13_09360) | mnmA | 1863491..1864613 (+) | 1123 | Protein_1794 | tRNA 2-thiouridine(34) synthase MnmA | - |
| FPL13_RS09235 (FPL13_09365) | mnmG | 1864749..1866668 (+) | 1920 | WP_192208623.1 | tRNA uridine-5-carboxymethylaminomethyl(34) synthesis enzyme MnmG | - |
| FPL13_RS09240 (FPL13_09370) | - | 1866917..1868893 (+) | 1977 | WP_049514061.1 | DHH family phosphoesterase | - |
| FPL13_RS09245 (FPL13_09375) | rplI | 1868890..1869342 (+) | 453 | WP_049514062.1 | 50S ribosomal protein L9 | - |
| FPL13_RS09250 (FPL13_09380) | dnaB | 1869374..1870726 (+) | 1353 | WP_049514064.1 | replicative DNA helicase | - |
| FPL13_RS09255 (FPL13_09385) | - | 1870730..1871002 (+) | 273 | WP_003027868.1 | Veg family protein | - |
Sequence
Protein
Download Length: 396 a.a. Molecular weight: 41638.61 Da Isoelectric Point: 9.4264
>NTDB_id=375035 FPL13_RS09080 WP_049512719.1 1835793..1836983(-) (htrA) [Streptococcus sp. KS 6]
MKNSSNFTKKLLLLFMVLAIGFIGGLLGNLTSSKLSTTSSTTTKVNQVTTAYKNTNSTTQAVSKVKDAVVSVITYANNNS
QNSVFGNDDSNNNNDNSQQVASEGSGVIYKKDGKYAYLVTNTHVISGAKKVDIRLADGNKVPGEIVGSDTYSDISVVRIS
ADKVKSVAEFGDSSKLTVGETAIAIGSPLGSNYANTVTQGIISSLNRNVSLKSEDGQTISTQAIQTDTAINPGNSGGPLV
NIQGQVIGITSSKIASNGGTSVEGLGFAIPSNDVINIINQLEANGTVTRPALGIQMIDITNLSSSDLSRLKLPSKITSGV
VVRSAQSGMPAEGKLQKYDVITKVDDKEISSTSDLQSALYKHSIGDNIKITFYRDGKETTTTIKLTKSTKDLDSNN
MKNSSNFTKKLLLLFMVLAIGFIGGLLGNLTSSKLSTTSSTTTKVNQVTTAYKNTNSTTQAVSKVKDAVVSVITYANNNS
QNSVFGNDDSNNNNDNSQQVASEGSGVIYKKDGKYAYLVTNTHVISGAKKVDIRLADGNKVPGEIVGSDTYSDISVVRIS
ADKVKSVAEFGDSSKLTVGETAIAIGSPLGSNYANTVTQGIISSLNRNVSLKSEDGQTISTQAIQTDTAINPGNSGGPLV
NIQGQVIGITSSKIASNGGTSVEGLGFAIPSNDVINIINQLEANGTVTRPALGIQMIDITNLSSSDLSRLKLPSKITSGV
VVRSAQSGMPAEGKLQKYDVITKVDDKEISSTSDLQSALYKHSIGDNIKITFYRDGKETTTTIKLTKSTKDLDSNN
Nucleotide
Download Length: 1191 bp
>NTDB_id=375035 FPL13_RS09080 WP_049512719.1 1835793..1836983(-) (htrA) [Streptococcus sp. KS 6]
ATGAAAAACTCTTCAAATTTCACAAAAAAATTGTTATTGCTTTTCATGGTCTTAGCTATAGGTTTTATTGGTGGTTTACT
TGGAAACTTAACTTCATCTAAATTATCAACAACTAGCTCTACAACGACTAAAGTTAATCAAGTTACTACTGCTTATAAAA
ATACAAATTCCACAACACAAGCTGTGAGTAAAGTAAAAGATGCTGTTGTATCCGTTATTACCTATGCTAATAATAATTCA
CAAAACAGTGTGTTTGGAAATGATGATTCAAATAATAACAATGATAATTCTCAACAAGTAGCTAGCGAAGGATCTGGAGT
TATTTATAAAAAAGATGGAAAATACGCTTACTTAGTAACCAATACCCACGTTATCAGTGGTGCTAAAAAAGTTGACATTC
GTTTAGCAGATGGTAATAAAGTTCCTGGAGAAATTGTAGGGTCAGATACTTATTCTGATATCTCCGTTGTTCGCATTAGT
GCTGATAAAGTAAAATCAGTTGCTGAATTTGGAGATTCTAGCAAATTGACTGTTGGTGAGACAGCTATTGCAATTGGAAG
TCCACTTGGTTCAAATTATGCTAATACTGTGACTCAAGGAATTATTTCTAGTTTAAATCGTAATGTTTCTCTAAAATCTG
AAGACGGACAAACGATTTCAACACAAGCTATTCAAACAGACACAGCTATCAACCCAGGGAACTCTGGTGGACCACTTGTG
AATATCCAAGGGCAAGTAATTGGTATTACTTCAAGTAAAATAGCTAGCAACGGCGGAACTTCGGTTGAAGGATTAGGATT
TGCTATTCCATCTAATGATGTTATAAACATTATTAACCAGTTAGAAGCAAATGGAACTGTTACACGACCAGCTCTAGGAA
TCCAAATGATTGACATCACTAATCTGTCTAGTTCAGATCTATCACGCTTAAAACTTCCATCAAAAATAACTAGTGGAGTT
GTCGTGCGTTCAGCTCAATCTGGAATGCCAGCTGAAGGAAAACTTCAAAAATATGATGTGATTACAAAAGTAGATGATAA
AGAAATTTCTTCAACAAGTGATTTACAATCTGCTTTATACAAACATTCAATTGGCGACAACATAAAAATCACTTTCTATC
GTGATGGAAAAGAAACTACTACTACCATTAAGCTTACAAAATCTACAAAAGATTTAGATTCAAATAATTGA
ATGAAAAACTCTTCAAATTTCACAAAAAAATTGTTATTGCTTTTCATGGTCTTAGCTATAGGTTTTATTGGTGGTTTACT
TGGAAACTTAACTTCATCTAAATTATCAACAACTAGCTCTACAACGACTAAAGTTAATCAAGTTACTACTGCTTATAAAA
ATACAAATTCCACAACACAAGCTGTGAGTAAAGTAAAAGATGCTGTTGTATCCGTTATTACCTATGCTAATAATAATTCA
CAAAACAGTGTGTTTGGAAATGATGATTCAAATAATAACAATGATAATTCTCAACAAGTAGCTAGCGAAGGATCTGGAGT
TATTTATAAAAAAGATGGAAAATACGCTTACTTAGTAACCAATACCCACGTTATCAGTGGTGCTAAAAAAGTTGACATTC
GTTTAGCAGATGGTAATAAAGTTCCTGGAGAAATTGTAGGGTCAGATACTTATTCTGATATCTCCGTTGTTCGCATTAGT
GCTGATAAAGTAAAATCAGTTGCTGAATTTGGAGATTCTAGCAAATTGACTGTTGGTGAGACAGCTATTGCAATTGGAAG
TCCACTTGGTTCAAATTATGCTAATACTGTGACTCAAGGAATTATTTCTAGTTTAAATCGTAATGTTTCTCTAAAATCTG
AAGACGGACAAACGATTTCAACACAAGCTATTCAAACAGACACAGCTATCAACCCAGGGAACTCTGGTGGACCACTTGTG
AATATCCAAGGGCAAGTAATTGGTATTACTTCAAGTAAAATAGCTAGCAACGGCGGAACTTCGGTTGAAGGATTAGGATT
TGCTATTCCATCTAATGATGTTATAAACATTATTAACCAGTTAGAAGCAAATGGAACTGTTACACGACCAGCTCTAGGAA
TCCAAATGATTGACATCACTAATCTGTCTAGTTCAGATCTATCACGCTTAAAACTTCCATCAAAAATAACTAGTGGAGTT
GTCGTGCGTTCAGCTCAATCTGGAATGCCAGCTGAAGGAAAACTTCAAAAATATGATGTGATTACAAAAGTAGATGATAA
AGAAATTTCTTCAACAAGTGATTTACAATCTGCTTTATACAAACATTCAATTGGCGACAACATAAAAATCACTTTCTATC
GTGATGGAAAAGAAACTACTACTACCATTAAGCTTACAAAATCTACAAAAGATTTAGATTCAAATAATTGA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| htrA | Streptococcus gordonii str. Challis substr. CH1 |
75.561 |
100 |
0.765 |
| htrA | Streptococcus mitis NCTC 12261 |
72.544 |
100 |
0.727 |
| htrA | Streptococcus pneumoniae Rx1 |
72.292 |
100 |
0.725 |
| htrA | Streptococcus pneumoniae D39 |
72.292 |
100 |
0.725 |
| htrA | Streptococcus pneumoniae R6 |
72.292 |
100 |
0.725 |
| htrA | Streptococcus pneumoniae TIGR4 |
72.292 |
100 |
0.725 |
| htrA | Streptococcus mutans UA159 |
55.216 |
99.242 |
0.548 |