Detailed information    

insolico Bioinformatically predicted

Overview

Name   hexA   Type   Machinery gene
Locus tag   G8B37_RS09140 Genome accession   NZ_CP049695
Coordinates   1826943..1829498 (-) Length   851 a.a.
NCBI ID   WP_011529121.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain ABC76     
Function   DNA mismatch repair (predicted from homology)   
Homologous recombination

Genomic Context

Location: 1821943..1834498
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  G8B37_RS09080 (G8B37_09160) - 1821967..1822140 (+) 174 WP_042769761.1 hypothetical protein -
  G8B37_RS09085 (G8B37_09165) - 1822146..1822319 (+) 174 WP_011529113.1 hypothetical protein -
  G8B37_RS09090 (G8B37_09170) - 1822321..1822587 (+) 267 WP_011529114.1 hypothetical protein -
  G8B37_RS09095 (G8B37_09175) - 1822594..1822752 (+) 159 WP_011529115.1 DUF2292 domain-containing protein -
  G8B37_RS09100 (G8B37_09180) - 1822853..1823455 (+) 603 WP_011529116.1 hypothetical protein -
  G8B37_RS09105 (G8B37_09185) - 1823445..1823774 (+) 330 WP_021299097.1 hypothetical protein -
  G8B37_RS09110 (G8B37_09190) - 1824050..1824316 (+) 267 WP_227868883.1 hypothetical protein -
  G8B37_RS09115 (G8B37_09195) - 1824422..1824835 (+) 414 WP_012560493.1 DUF1492 domain-containing protein -
  G8B37_RS09120 (G8B37_09200) - 1824910..1825110 (+) 201 WP_011529120.1 hypothetical protein -
  G8B37_RS09125 (G8B37_09205) - 1825177..1825371 (+) 195 Protein_1752 DUF1492 domain-containing protein -
  G8B37_RS09130 (G8B37_09210) - 1825346..1825729 (+) 384 WP_011285285.1 ArpU family phage packaging/lysis transcriptional regulator -
  G8B37_RS09135 (G8B37_09215) - 1825930..1826547 (+) 618 WP_021340716.1 hypothetical protein -
  G8B37_RS09140 (G8B37_09220) hexA 1826943..1829498 (-) 2556 WP_011529121.1 DNA mismatch repair protein MutS Machinery gene
  G8B37_RS09690 (G8B37_09225) - 1829485..1829837 (-) 353 Protein_1756 YlbF family regulator -
  G8B37_RS09150 (G8B37_09230) argR 1829834..1830271 (-) 438 WP_002982171.1 arginine repressor -
  G8B37_RS09155 (G8B37_09235) argS 1830562..1832253 (+) 1692 WP_011529123.1 arginine--tRNA ligase -
  G8B37_RS09160 (G8B37_09240) - 1832341..1832649 (+) 309 WP_012561077.1 bacteriocin immunity protein -
  G8B37_RS09165 (G8B37_09245) - 1832676..1833548 (-) 873 WP_011529124.1 YitT family protein -
  G8B37_RS09170 (G8B37_09250) - 1833591..1834469 (-) 879 WP_021299113.1 YitT family protein -

Sequence

Protein


Download         Length: 851 a.a.        Molecular weight: 95518.08 Da        Isoelectric Point: 5.0199

>NTDB_id=375022 G8B37_RS09140 WP_011529121.1 1826943..1829498(-) (hexA) [Streptococcus pyogenes strain ABC76]
MAKTNISPGMQQYLDIKKDYPDAFLLFRMGDFYELFYEDAVKAAQLLEIGLTSRNKNAENPIPMAGVPHHSAQQYIDVLI
ELGYKVAVAEQMEDPKQAVGVVKREVVQVITPGTVVDSAKPDSANNFLVAIDFDGCRYGLAYMDVSTGEFCVTDLADFTS
VRSEIQNLKAKEVLLGFDLSEEEQTILVKQMNLLLSYEETVYEDKSLIDGQLTTVELTAAGKLLQYVHKTQMRELSHLQA
LVHYEIKDYLQMSYATKSSLDLVENARTNKKHGSLYWLLDETKTAMGMRLLRSWIDRPLVSKEAILERQEIIQVFLNAFI
ERTDLSNSLKGVYDIERLSSRVSFGKANPKDLLQLGHTLAQVPYIKAILESFNSAYVDKLVNDIDSLPELEYLIRTAIDP
DAPATISEGSIIRNGFDERLDHYRKVMREGTGWIADIEAKERQASGINNLKIDYNKKDGYYFHVTNSNLSLVPDHFFRKA
TLKNSERYGTAELAKIEGQMLEAREESSSLEYDIFMCIRAQVETYINRLQKLAKILATVDVLQSLAVVAETNHYIRPQFN
DNHVITIQEGRHAVVEKVMGVQEYIPNSISFDQQTSIQLITGPNMSGKSTYMRQLALTVIMAQMGSFVAADHVDLPLFDA
IFTRIGAADDLISGQSTFMVEMMEANQAIKRASDNSLILFDELGRGTATYDGMALAQAIIEYIHDRVGAKTIFATHYHEL
TDLSTKLTSLVNVHVATLEKDGDVTFLHKIAEGPADKSYGIHVAKIAGLPKSLLKRADEVLTRLETQSRSTEIMSVPPQV
ESSSAVRQGQLSLFGDEEKAHEIRQALEAIDVMNMTPLQAMTTLYELKKLL

Nucleotide


Download         Length: 2556 bp        

>NTDB_id=375022 G8B37_RS09140 WP_011529121.1 1826943..1829498(-) (hexA) [Streptococcus pyogenes strain ABC76]
ATGGCAAAAACTAACATTTCTCCTGGAATGCAACAGTATCTGGACATCAAAAAAGATTATCCAGATGCTTTTTTGCTTTT
TAGGATGGGTGACTTTTATGAATTATTTTACGAGGACGCTGTCAAAGCAGCACAACTCTTAGAAATTGGTTTGACCAGTC
GCAACAAGAATGCGGAAAATCCAATTCCCATGGCAGGCGTGCCACATCATTCTGCCCAACAATACATTGATGTGTTAATT
GAGTTGGGTTACAAGGTTGCTGTCGCAGAACAAATGGAAGACCCAAAGCAAGCTGTTGGGGTGGTGAAGCGTGAGGTCGT
TCAAGTCATAACTCCTGGAACGGTTGTGGATTCAGCTAAGCCAGATAGCGCCAATAACTTTTTGGTAGCTATTGACTTTG
ATGGTTGCCGTTATGGATTGGCTTATATGGATGTGTCCACAGGTGAATTTTGCGTGACAGATTTGGCGGACTTTACGAGT
GTTCGTAGCGAAATCCAAAACCTCAAGGCAAAAGAAGTCTTACTAGGTTTTGATTTATCTGAAGAAGAACAGACGATTTT
GGTCAAGCAGATGAATTTGCTGCTTTCTTATGAAGAAACGGTCTATGAAGATAAATCTTTAATTGACGGTCAATTGACAA
CGGTAGAACTGACAGCGGCAGGAAAACTCTTGCAATACGTTCACAAAACACAAATGCGAGAACTCAGCCACTTGCAAGCC
TTGGTTCACTATGAAATCAAGGATTATTTGCAGATGTCGTATGCCACTAAGTCAAGTCTAGATTTGGTAGAGAATGCTAG
AACGAATAAAAAACATGGGAGTCTGTATTGGCTGTTAGATGAAACCAAGACAGCTATGGGGATGAGGCTTTTGCGCTCAT
GGATTGATCGACCTTTGGTTTCTAAAGAAGCTATTTTAGAGCGTCAAGAAATTATTCAAGTTTTTCTGAATGCTTTTATT
GAGCGAACAGATTTAAGCAATAGCTTAAAAGGTGTTTACGATATCGAACGCTTATCTAGCCGTGTGTCTTTTGGCAAGGC
AAATCCGAAAGATTTACTTCAATTGGGGCATACCTTAGCCCAAGTGCCTTATATCAAAGCCATATTAGAGTCTTTTAACA
GCGCTTATGTTGACAAACTTGTCAATGATATTGACAGTTTGCCTGAGTTGGAATACTTGATTAGAACAGCCATTGATCCA
GATGCACCAGCAACTATTAGTGAAGGAAGTATTATCCGCAATGGTTTTGATGAGCGCTTGGACCATTATCGTAAAGTAAT
GCGAGAGGGGACAGGCTGGATTGCGGATATTGAGGCCAAAGAGCGTCAAGCAAGTGGCATTAATAACCTAAAAATTGATT
ACAATAAAAAAGATGGTTATTATTTTCACGTTACGAATTCAAATCTTAGCTTAGTTCCCGACCATTTTTTCAGAAAGGCA
ACTTTAAAAAATTCTGAGCGTTATGGAACAGCAGAATTGGCTAAGATTGAAGGTCAGATGTTAGAGGCTAGGGAAGAGTC
ATCTAGTTTAGAATACGATATTTTTATGTGTATTCGAGCTCAAGTTGAAACCTATATTAATCGTTTACAGAAACTGGCTA
AAATTTTGGCAACGGTAGATGTTTTGCAAAGTTTAGCAGTCGTTGCTGAAACCAATCATTATATCCGGCCGCAGTTCAAT
GATAATCATGTGATTACAATTCAAGAAGGTCGTCACGCGGTTGTTGAAAAGGTTATGGGAGTGCAGGAATACATTCCCAA
TAGTATCTCTTTTGACCAACAGACCAGTATTCAGCTGATTACAGGTCCAAATATGAGTGGTAAGTCGACTTATATGAGAC
AGCTGGCCTTAACGGTTATCATGGCCCAGATGGGTTCATTTGTGGCTGCTGACCATGTTGATTTACCTTTATTTGATGCG
ATTTTTACGCGTATTGGGGCTGCTGATGATTTGATTTCTGGGCAATCAACCTTTATGGTGGAGATGATGGAAGCAAACCA
AGCAATCAAACGCGCAAGTGACAACTCTCTTATTCTATTTGATGAACTGGGACGAGGTACGGCAACTTATGATGGTATGG
CTTTAGCCCAGGCAATTATTGAATATATCCATGATAGAGTTGGTGCTAAGACCATATTTGCAACGCATTATCATGAATTG
ACAGACTTGTCAACTAAGTTGACAAGTCTAGTCAATGTTCATGTAGCAACGCTTGAAAAAGATGGCGATGTTACCTTCCT
TCATAAGATTGCTGAGGGACCGGCGGATAAATCTTACGGTATTCATGTTGCAAAAATAGCAGGACTGCCAAAATCCCTAT
TAAAGAGAGCAGACGAAGTTCTGACCCGTTTAGAAACACAGTCACGATCTACTGAGATAATGTCAGTCCCTCCACAAGTT
GAGTCAAGCAGCGCTGTTAGACAGGGGCAATTATCCCTTTTTGGTGATGAAGAGAAAGCTCATGAGATTAGGCAAGCACT
GGAAGCTATTGATGTCATGAATATGACCCCGCTTCAAGCAATGACAACCCTTTACGAATTGAAAAAGTTGTTATAG

Domains

Predicted by InterProScan.

MutS family domain IV (MutS_IV)

(415-506)

MutS domain II (MutS_II)

(126-239)

MutS domain V (MutS_V)

(599-785)

MutS domain I (MutS_I)

(8-118)

MutS domain III (MutS_III)

(256-546)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  hexA Streptococcus pneumoniae R6

71.563

100

0.716
  mutS Pseudomonas stutzeri strain ATCC 17587

36.959

100

0.371

Multiple sequence alignment