Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   FOF38_RS01255 Genome accession   NZ_CP041665
Coordinates   259620..260909 (-) Length   429 a.a.
NCBI ID   WP_002290101.1    Uniprot ID   A0A828ZUK2
Organism   Enterococcus faecium strain CX2-6     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 254620..265909
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  FOF38_RS01225 (FOF38_01265) - 254956..255903 (-) 948 WP_002292628.1 glycosyltransferase family 2 protein -
  FOF38_RS01230 (FOF38_01270) - 256126..256476 (-) 351 WP_002292629.1 PepSY domain-containing protein -
  FOF38_RS01235 (FOF38_01275) pepA 256676..257755 (+) 1080 WP_002294156.1 glutamyl aminopeptidase -
  FOF38_RS01240 (FOF38_01280) - 257898..258218 (+) 321 WP_002292632.1 thioredoxin family protein -
  FOF38_RS01245 (FOF38_01285) - 258240..258704 (+) 465 WP_002292633.1 universal stress protein -
  FOF38_RS01250 (FOF38_01295) ytpR 258909..259514 (+) 606 WP_002292634.1 YtpR family tRNA-binding protein -
  FOF38_RS01255 (FOF38_01300) htrA 259620..260909 (-) 1290 WP_002290101.1 S1C family serine protease Regulator
  FOF38_RS01260 (FOF38_01305) rlmH 261337..261816 (+) 480 WP_002329688.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  FOF38_RS01265 (FOF38_01310) - 261968..263137 (+) 1170 WP_002313998.1 IS256 family transposase -
  FOF38_RS01270 (FOF38_01315) - 263253..263501 (+) 249 WP_002292290.1 GlsB/YeaQ/YmgE family stress response membrane protein -
  FOF38_RS01275 (FOF38_01320) - 263701..264105 (+) 405 WP_002292291.1 organic hydroperoxide resistance protein -
  FOF38_RS01280 (FOF38_01325) - 264238..265281 (+) 1044 WP_002292292.1 hypothetical protein -
  FOF38_RS01285 (FOF38_01330) - 265296..265859 (+) 564 WP_002294754.1 restriction endonuclease subunit S -

Sequence

Protein


Download         Length: 429 a.a.        Molecular weight: 44916.93 Da        Isoelectric Point: 4.5419

>NTDB_id=372851 FOF38_RS01255 WP_002290101.1 259620..260909(-) (htrA) [Enterococcus faecium strain CX2-6]
MDRKNVTPKMKKNKNNSLWRKLGLGLVGGIVGGLLTAGIFYAAMGTGNNSSTATSGNQNSAGETVVENVKVNVDSDITKA
VDKVQDAVVSVINLQSQNQSSGFGGLFGQQEESSSSDDSNLEAYSEGSGVIYKKDGNTAYVVTNNHVVDGQQGLEVMMKD
GTKVKAELVGTDAYSDLAVLKINSDKVETVASFGDSSALKVGEPAIAIGSPLGSEYANSVTSGIISSLNRQVTSTNESNE
TVNINAIQTDAAINPGNSGGPLVNIEGQVIGINSSKIASTSESTSNVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPALG
ITMVDLSAVSTQQQEQILKIPSSVTNGVIVTNVQTATPAEKAGLKQYDVITKIDDKEVSSGVELQSALYKKKVGDSVKIT
YYEGSKEKTTTVELTIDQSALKQNQNSEN

Nucleotide


Download         Length: 1290 bp        

>NTDB_id=372851 FOF38_RS01255 WP_002290101.1 259620..260909(-) (htrA) [Enterococcus faecium strain CX2-6]
ATGGATAGAAAAAATGTGACACCAAAGATGAAAAAAAATAAAAATAATAGCCTCTGGCGTAAGTTGGGTCTGGGGCTTGT
TGGAGGGATCGTTGGAGGACTACTGACAGCTGGCATTTTTTATGCAGCGATGGGCACTGGCAACAATAGTTCTACTGCTA
CAAGCGGCAATCAAAATTCAGCCGGTGAAACAGTTGTCGAAAATGTCAAAGTCAATGTAGATTCTGATATCACCAAAGCG
GTAGATAAAGTTCAAGACGCTGTCGTTTCTGTTATCAACTTACAAAGTCAAAATCAATCAAGCGGTTTTGGCGGATTATT
CGGGCAGCAAGAAGAAAGTAGCAGCTCAGATGATAGTAATTTGGAAGCTTATAGTGAAGGAAGCGGCGTGATCTACAAAA
AAGACGGGAATACTGCTTATGTAGTCACAAACAACCACGTAGTAGATGGACAGCAAGGTTTGGAAGTCATGATGAAAGAC
GGGACGAAAGTAAAAGCTGAATTAGTTGGAACAGATGCTTATTCAGATTTAGCGGTGTTGAAGATCAATTCAGATAAAGT
CGAAACGGTTGCCTCTTTTGGTGACTCAAGCGCTCTAAAGGTTGGTGAACCTGCGATTGCGATTGGTTCCCCATTAGGAT
CTGAATATGCGAATTCTGTCACTTCAGGAATCATTTCTTCTTTGAATCGACAAGTAACAAGTACGAATGAATCGAACGAA
ACAGTCAATATCAATGCGATCCAAACAGATGCAGCGATCAACCCGGGAAATTCTGGTGGTCCTTTAGTGAATATCGAAGG
ACAAGTTATCGGTATCAACTCAAGTAAGATCGCAAGTACTTCTGAATCGACTTCTAATGTAAGCGTAGAAGGAATGGGAT
TTGCTATTCCAAGTAACGATGTAGTGAATATCATCAATCAACTGGAAAAAGACGGAAAAGTGACACGTCCAGCTCTAGGT
ATCACAATGGTCGACTTATCTGCCGTTTCTACTCAGCAACAAGAACAAATCTTGAAGATTCCTTCATCTGTAACTAACGG
TGTCATCGTGACAAATGTCCAAACAGCTACACCGGCTGAAAAAGCTGGATTGAAACAATATGATGTCATTACTAAGATCG
ATGACAAAGAAGTTTCTTCTGGCGTAGAACTTCAATCTGCTTTGTATAAGAAAAAAGTGGGAGATTCTGTCAAAATCACT
TACTATGAAGGCTCGAAAGAAAAAACAACTACTGTTGAATTGACGATCGATCAATCGGCATTAAAACAAAATCAAAATAG
TGAAAATTAA

Domains

Predicted by InterproScan.

Peptidase family M50 (Peptidase_M50)

(10-417)

Trypsin-like peptidase domain (Trypsin_2)

(127-272)

PDZ domain (PDZ_2)

(317-414)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A828ZUK2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

54.569

91.841

0.501
  htrA Streptococcus mutans UA159

60.169

82.517

0.496
  htrA Streptococcus mitis NCTC 12261

52.778

92.308

0.487
  htrA Streptococcus pneumoniae TIGR4

59.05

78.555

0.464
  htrA Streptococcus pneumoniae Rx1

59.05

78.555

0.464
  htrA Streptococcus pneumoniae D39

59.05

78.555

0.464
  htrA Streptococcus pneumoniae R6

59.05

78.555

0.464

Multiple sequence alignment