Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   WPAWT_RS11685 Genome accession   NZ_CP049161
Coordinates   2470946..2471617 (+) Length   223 a.a.
NCBI ID   WP_003090494.1    Uniprot ID   A0A0H2ZC88
Organism   Pseudomonas aeruginosa strain MS14403     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 2465946..2476617
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  WPAWT_RS11650 (WPAWT_02329) ppyR 2466419..2466676 (+) 258 WP_003090502.1 psl/pyoverdine operon transcriptional regulator PpyR -
  WPAWT_RS11655 (WPAWT_02330) - 2466663..2467856 (+) 1194 WP_003122598.1 NnrS family protein -
  WPAWT_RS11660 (WPAWT_02331) - 2467857..2468123 (-) 267 WP_003115326.1 DUF5329 domain-containing protein -
  WPAWT_RS11665 (WPAWT_02332) - 2468107..2469000 (-) 894 WP_253941125.1 hypothetical protein -
  WPAWT_RS11670 (WPAWT_02333) - 2469027..2470109 (-) 1083 WP_003113385.1 hypothetical protein -
  WPAWT_RS11675 (WPAWT_02334) - 2470324..2470632 (+) 309 WP_003090497.1 PepSY domain-containing protein -
  WPAWT_RS11680 (WPAWT_02335) - 2470632..2470946 (+) 315 WP_003097704.1 PepSY domain-containing protein -
  WPAWT_RS11685 (WPAWT_02336) ciaR 2470946..2471617 (+) 672 WP_003090494.1 two-component system response regulator CarR Regulator
  WPAWT_RS11690 (WPAWT_02337) carS 2471614..2472951 (+) 1338 WP_003090493.1 two-component system sensor histidine kinase CarS -
  WPAWT_RS11695 (WPAWT_02338) - 2473042..2473350 (+) 309 WP_171978550.1 hypothetical protein -
  WPAWT_RS11700 (WPAWT_02339) - 2473355..2475499 (-) 2145 WP_003113383.1 methyl-accepting chemotaxis protein -

Sequence

Protein


Download         Length: 223 a.a.        Molecular weight: 24729.20 Da        Isoelectric Point: 5.8445

>NTDB_id=372733 WPAWT_RS11685 WP_003090494.1 2470946..2471617(+) (ciaR) [Pseudomonas aeruginosa strain MS14403]
MRLLLVEDHVPLADELMASLTRQGYAVDWLADGRDAAVQGASEPYDLIILDLGLPGRPGLEILQEWRGLGLATPVLILTA
RGSWAERIDGLKAGADDYLTKPFHPEELALRIQALLRRAHGLANQSQLEAAGLRLDEQRQCVCLNGADVDLTAAEFRLLR
YFMLHPGQVLSKGHLAEHLYDGETERDSNVIEVHVNHLRRKLGREVIETRRGQGYRYAGVAAG

Nucleotide


Download         Length: 672 bp        

>NTDB_id=372733 WPAWT_RS11685 WP_003090494.1 2470946..2471617(+) (ciaR) [Pseudomonas aeruginosa strain MS14403]
ATGCGGTTGCTGCTGGTTGAGGATCACGTTCCCCTGGCCGACGAACTGATGGCCAGCCTGACCCGCCAGGGCTACGCGGT
GGACTGGCTGGCCGACGGCCGCGACGCGGCGGTGCAGGGCGCCAGCGAACCCTACGACCTGATCATCCTCGACCTCGGCC
TGCCCGGGCGTCCCGGCCTGGAGATACTCCAGGAGTGGCGTGGGCTGGGACTCGCGACTCCGGTGCTGATCCTCACCGCG
CGCGGTTCCTGGGCCGAACGCATCGATGGGCTCAAGGCCGGTGCCGACGACTACCTGACCAAGCCGTTCCATCCGGAAGA
GCTGGCCTTGCGCATCCAGGCCCTGTTGCGCCGCGCCCATGGGCTGGCCAACCAGAGCCAGCTGGAGGCCGCCGGGCTGC
GCCTGGACGAGCAGCGCCAGTGCGTGTGCCTGAACGGCGCCGACGTCGACCTGACCGCCGCCGAATTCCGCCTGCTGCGC
TATTTCATGCTGCACCCCGGCCAGGTCCTGTCCAAGGGGCACCTGGCCGAGCATCTGTACGACGGCGAGACCGAACGCGA
TTCCAACGTCATCGAGGTCCACGTCAACCACCTGCGGCGCAAGCTCGGCCGCGAGGTGATCGAGACCCGCCGTGGCCAGG
GCTACCGCTACGCCGGGGTGGCCGCCGGATGA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(147-216)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0H2ZC88

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus mutans UA159

37.727

98.655

0.372
  ciaR Streptococcus pneumoniae Rx1

37.273

98.655

0.368
  ciaR Streptococcus pneumoniae D39

37.273

98.655

0.368
  ciaR Streptococcus pneumoniae R6

37.273

98.655

0.368
  ciaR Streptococcus pneumoniae TIGR4

37.273

98.655

0.368
  micA Streptococcus pneumoniae Cp1015

35.683

100

0.363
  vicR Streptococcus mutans UA159

35.526

100

0.363