Detailed information NTG0368606

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: FIU13_RS05795
• Genome accession: NZ_CP040997
• Coordinates: 1113263..1114174 (+)
• Length: 303 a.a.
• NCBI ID: WP_029714263.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain FDAARGOS_774
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1108263..1119174

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FIU13_RS05775 (FIU13_05775)	purE	1108600..1109091 (+)	492	WP_002987716.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
FIU13_RS05780 (FIU13_05780)	purK	1109078..1110151 (+)	1074	WP_029714261.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
FIU13_RS05785 (FIU13_05785)	-	1110178..1111821 (+)	1644	WP_010921779.1	AIPR family protein	-
FIU13_RS05790 (FIU13_05790)	purB	1111839..1113131 (+)	1293	WP_010921780.1	adenylosuccinate lyase	-
FIU13_RS05795 (FIU13_05795)	comR	1113263..1114174 (+)	912	WP_029714263.1	transcriptional regulator Rgg4/ComR	Regulator
FIU13_RS10485	comS	1114258..1114353 (+)	96	WP_198462994.1	quorum-sensing system DWW-type pheromone	Regulator
FIU13_RS05800 (FIU13_05800)	ruvB	1114400..1115398 (+)	999	WP_002986679.1	Holliday junction branch migration DNA helicase RuvB	-
FIU13_RS05805 (FIU13_05805)	-	1115536..1115973 (+)	438	WP_002994668.1	low molecular weight protein-tyrosine-phosphatase	-
FIU13_RS05810 (FIU13_05810)	-	1115996..1116397 (+)	402	WP_010921781.1	MORN repeat-containing protein	-
FIU13_RS05815 (FIU13_05815)	-	1116394..1118169 (+)	1776	WP_010921782.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35787.30 Da
• Isoelectric Point: 4.4858

>NTDB_id=368606 FIU13_RS05795 WP_029714263.1 1113263..1114174(+) (comR) [Streptococcus pyogenes strain FDAARGOS_774]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQTTLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide

• Length: 912 bp

>NTDB_id=368606 FIU13_RS05795 WP_029714263.1 1113263..1114174(+) (comR) [Streptococcus pyogenes strain FDAARGOS_774]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGACAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

• ComR tetratricopeptide (ComR_TPR) (73-296)

• Helix-turn-helix (HTH_3) (12-64)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS8232	99.67	100	0.997
comR	Streptococcus pyogenes MGAS315	58.14	99.34	0.578
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	51.37	96.37	0.495
comR	Streptococcus mutans UA159	46.358	99.67	0.462