Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   FHK66_RS08990 Genome accession   NZ_CP040849
Coordinates   1729081..1730370 (+) Length   429 a.a.
NCBI ID   WP_002319485.1    Uniprot ID   -
Organism   Enterococcus faecium strain F17E0263     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1724081..1735370
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  FHK66_RS08970 (FHK66_08970) - 1724219..1725127 (-) 909 WP_010778368.1 IS982-like element ISEfm1 family transposase -
  FHK66_RS08975 (FHK66_08975) - 1725295..1726425 (-) 1131 WP_002317111.1 hypothetical protein -
  FHK66_RS08980 (FHK66_08980) - 1726636..1727798 (+) 1163 WP_113787899.1 IS3 family transposase -
  FHK66_RS08985 (FHK66_08985) rlmH 1728173..1728652 (-) 480 WP_002287841.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  FHK66_RS08990 (FHK66_08990) htrA 1729081..1730370 (+) 1290 WP_002319485.1 S1C family serine protease Regulator
  FHK66_RS08995 (FHK66_08995) ytpR 1730409..1731014 (-) 606 WP_002294153.1 YtpR family tRNA-binding protein -
  FHK66_RS09000 (FHK66_09000) - 1731221..1731685 (-) 465 WP_002292633.1 universal stress protein -
  FHK66_RS09005 (FHK66_09005) - 1731707..1732027 (-) 321 WP_002287837.1 thioredoxin family protein -
  FHK66_RS09010 (FHK66_09010) pepA 1732170..1733249 (-) 1080 WP_002294156.1 glutamyl aminopeptidase -
  FHK66_RS09015 (FHK66_09015) - 1733449..1733799 (+) 351 WP_002289862.1 PepSY domain-containing protein -
  FHK66_RS09020 (FHK66_09020) - 1734022..1734969 (+) 948 WP_002289860.1 glycosyltransferase family 2 protein -

Sequence

Protein


Download         Length: 429 a.a.        Molecular weight: 44898.89 Da        Isoelectric Point: 4.5419

>NTDB_id=367593 FHK66_RS08990 WP_002319485.1 1729081..1730370(+) (htrA) [Enterococcus faecium strain F17E0263]
MDRKNVTPKMKKNKNNSLWRKLGLGLVGGIVGGLLTAGIFYAAMGTGNNSSTATSGNQNSAGETVVENVKVNVDSDITKA
VDKVQDAVVSVINLQSQNQSSGFGGLFGQQEESSSSDDSNLEAYSEGSGVIYKKDGNTAYVVTNNHVVDGQQGLEVLMKD
GTKVKAELVGTDAYSDLAVLKINSDKVETVASFGDSSALKVGEPAIAIGSPLGSEYANSVTSGIISSLNRQVTSTNESNE
TVNINAIQTDAAINPGNSGGPLVNIEGQVIGINSSKIASTSESTSNVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPALG
ITMVDLSAVSTQQQEQILKIPSSVTNGVIVTNVQTATPAEKAGLKQYDVITKIDDKEVSSGVELQSALYKKKVGDSVKIT
YYEGSKEKTTTVELTIDQSALKQNQNSEN

Nucleotide


Download         Length: 1290 bp        

>NTDB_id=367593 FHK66_RS08990 WP_002319485.1 1729081..1730370(+) (htrA) [Enterococcus faecium strain F17E0263]
ATGGATAGAAAAAATGTGACACCAAAGATGAAAAAAAATAAAAATAATAGCCTCTGGCGTAAGTTAGGTCTGGGGCTTGT
TGGAGGGATCGTTGGAGGACTACTGACAGCTGGCATTTTTTATGCAGCGATGGGCACTGGCAACAATAGTTCTACTGCTA
CAAGCGGCAATCAGAATTCTGCCGGTGAAACAGTTGTGGAAAATGTCAAAGTCAATGTAGATTCTGATATCACCAAAGCG
GTAGATAAAGTTCAAGACGCTGTCGTTTCTGTTATCAACTTACAAAGTCAAAACCAATCAAGCGGTTTTGGCGGACTATT
CGGGCAGCAAGAAGAAAGTAGCAGCTCAGATGATAGTAATTTGGAAGCTTATAGTGAAGGAAGCGGCGTGATCTACAAAA
AAGACGGGAATACTGCTTATGTAGTCACGAATAATCACGTAGTAGATGGCCAGCAAGGTCTTGAAGTCTTGATGAAAGAC
GGTACGAAGGTAAAAGCTGAATTAGTTGGAACAGATGCTTATTCAGATTTAGCGGTGTTGAAGATCAATTCAGACAAAGT
CGAAACAGTTGCCTCTTTTGGTGACTCAAGTGCTCTGAAGGTTGGTGAGCCTGCGATTGCGATTGGTTCCCCACTAGGAT
CTGAATATGCAAATTCTGTCACTTCAGGAATCATTTCTTCCTTGAACCGACAAGTGACAAGTACGAATGAATCGAACGAA
ACAGTCAATATCAATGCGATCCAAACAGATGCAGCAATCAACCCTGGAAATTCTGGTGGTCCTTTAGTTAATATCGAAGG
ACAAGTTATCGGTATCAACTCAAGTAAGATCGCAAGTACTTCTGAATCTACTTCTAATGTAAGCGTAGAAGGAATGGGAT
TTGCTATTCCAAGTAACGATGTAGTGAATATCATCAATCAACTGGAAAAAGACGGAAAAGTGACACGTCCAGCTCTAGGT
ATCACAATGGTCGACTTATCTGCCGTTTCTACTCAGCAACAAGAACAAATCTTGAAGATTCCTTCATCTGTAACTAACGG
TGTCATCGTGACAAATGTCCAAACAGCTACACCGGCTGAAAAAGCTGGATTGAAACAATACGACGTCATTACTAAGATCG
ATGACAAAGAAGTTTCTTCTGGTGTAGAACTTCAATCTGCTTTGTATAAGAAAAAAGTGGGAGATTCTGTCAAAATCACT
TACTATGAAGGCTCGAAAGAAAAAACAACTACTGTTGAATTGACGATCGATCAATCGGCATTAAAACAAAATCAAAATAG
TGAAAATTAA

Domains

Predicted by InterproScan.

Peptidase family M50 (Peptidase_M50)

(10-417)

PDZ domain (PDZ_2)

(317-414)

Trypsin-like peptidase domain (Trypsin_2)

(127-272)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

54.569

91.841

0.501
  htrA Streptococcus mutans UA159

59.887

82.517

0.494
  htrA Streptococcus mitis NCTC 12261

52.778

92.308

0.487
  htrA Streptococcus pneumoniae TIGR4

59.05

78.555

0.464
  htrA Streptococcus pneumoniae Rx1

59.05

78.555

0.464
  htrA Streptococcus pneumoniae D39

59.05

78.555

0.464
  htrA Streptococcus pneumoniae R6

59.05

78.555

0.464

Multiple sequence alignment